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  1. Extraintestinal pathogenic E. coli (ExPEC) is a common gram-negative organism causing various infections, including urinary tract infections (UTIs), bacteremia, and neonatal meningitis. The cjrABC-senB gene clust...

    Authors: Wen-Chun Huang, Yi-Jyun Liao, Masayuki Hashimoto, Kuan-Fu Chen, Chishih Chu, Po-Chuen Hsu, Shuying Wang and Ching-Hao Teng

    Citation: Journal of Biomedical Science 2020 27:86

    Content type: Research

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  2. Pseudomonas aeruginosa is a Gram-negative pathogen that frequently causes life-threatening infections in immunocompromised patients. We previously showed that subinhibitory concentrations of short synthetic pepti...

    Authors: Iosu Rázquin-Olazarán, Hawraa Shahrour and Guillermo Martínez-de-Tejada

    Citation: Journal of Biomedical Science 2020 27:85

    Content type: Research

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  3. Precision medicine is becoming the standard of care in anti-cancer treatment. The personalized precision management of cancer patients highly relies on the improvement of new technology in next generation sequ...

    Authors: Wen-Chi Yang, Feng-Ming Hsu and Pan-Chyr Yang

    Citation: Journal of Biomedical Science 2020 27:82

    Content type: Review

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  4. Recent trials have shown promise in intra-arterial thrombectomy after the first 6–24 h of stroke onset. Quick and precise identification of the salvageable tissue is essential for successful stroke management....

    Authors: Duen-Pang Kuo, Po-Chih Kuo, Yung-Chieh Chen, Yu-Chieh Jill Kao, Ching-Yen Lee, Hsiao-Wen Chung and Cheng-Yu Chen

    Citation: Journal of Biomedical Science 2020 27:80

    Content type: Research

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  5. 5-methoxytryptophan (5-MTP) is an endothelial factor with anti-inflammatory properties. It is synthesized from L-tryptophan via two enzymatic steps: tryptophan hydroxylase-1 (TPH-1) and hydroxyindole O-methylt...

    Authors: Kenneth K. Wu, Cheng-Chin Kuo, Shaw-Fang Yet, Chii-Ming Lee and Jun-Yang Liou

    Citation: Journal of Biomedical Science 2020 27:79

    Content type: Review

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  6. N-linked glycosylation is one of the most abundant posttranslational modifications of membrane-bound proteins in eukaryotes and affects a number of biological activities, including protein biosynthesis, protein.....

    Authors: Ying-Nai Wang, Heng-Huan Lee, Jennifer L. Hsu, Dihua Yu and Mien-Chie Hung

    Citation: Journal of Biomedical Science 2020 27:77

    Content type: Review

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  7. Monoclonal antibodies (mAbs) are a major targeted therapy for malignancies, infectious diseases, autoimmune diseases, transplant rejection and chronic inflammatory diseases due to their antigen specificity and...

    Authors: Wen-Wei Lin, Yun-Chi Lu, Chih-Hung Chuang and Tian-Lu Cheng

    Citation: Journal of Biomedical Science 2020 27:76

    Content type: Review

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  8. ZNF322A is an oncogenic transcription factor that belongs to the Cys2His2-type zinc-finger protein family. Accumulating evidence suggests that ZNF322A may contribute to the tumorigenesis of lung cancer, howeve...

    Authors: Chantal Hoi Yin Cheung, Chia-Lang Hsu, Tsai-Yu Lin, Wei-Ting Chen, Yi-Ching Wang, Hsuan-Cheng Huang and Hsueh-Fen Juan

    Citation: Journal of Biomedical Science 2020 27:75

    Content type: Research

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  9. Pulmonary diseases due to mycobacteria cause significant morbidity and mortality to human health. In addition to tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), recent epidemiological studies have ...

    Authors: Radha Gopalaswamy, Sivakumar Shanmugam, Rajesh Mondal and Selvakumar Subbian

    Citation: Journal of Biomedical Science 2020 27:74

    Content type: Review

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  10. SARS-CoV-2 began spreading in December 2019 and has since become a pandemic that has impacted many aspects of human society. Several issues concerning the origin, time of introduction to humans, evolutionary p...

    Authors: Shu-Miaw Chaw, Jui-Hung Tai, Shi-Lun Chen, Chia-Hung Hsieh, Sui-Yuan Chang, Shiou-Hwei Yeh, Wei-Shiung Yang, Pei-Jer Chen and Hurng-Yi Wang

    Citation: Journal of Biomedical Science 2020 27:73

    Content type: Research

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  11. On March 11, 2020, the World Health Organization declared the worldwide spread of the infectious disease COVID-19, caused by a new strain of coronavirus, SARS-CoV-2, as a pandemic. Like in all other infectious...

    Authors: Feng-Yee Chang, Hsiang-Cheng Chen, Pei-Jer Chen, Mei-Shang Ho, Shie-Liang Hsieh, Jung-Chung Lin, Fu-Tong Liu and Huey-Kang Sytwu

    Citation: Journal of Biomedical Science 2020 27:72

    Content type: Review

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  12. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Hui Liang, Nathanael Matei, Devin W. McBride, Yang Xu, Jiping Tang, Benyan Luo and John H. Zhang

    Citation: Journal of Biomedical Science 2020 27:71

    Content type: Correction

    Published on:

    The original article was published in Journal of Biomedical Science 2020 27:61

  13. Hepatitis B virus (HBV) persistently infected about 250 million people worldwide, and a curative treatment remains an unmet medical need. Among many approaches to treat chronic hepatitis B (CHB), therapeutic v...

    Authors: Jau-Hau Horng, Wei-Hsiang Lin, Chang-Ru Wu, You-Yu Lin, Li-Ling Wu, Ding-Shinn Chen and Pei-Jer Chen

    Citation: Journal of Biomedical Science 2020 27:70

    Content type: Research

    Published on:

  14. Due to differences in genetic background, it is unclear whether the genetic loci identified by the previous genome-wide association studies (GWAS) of pancreatic cancer also play significant roles in the develo...

    Authors: Yan-Shen Shan, Li-Tzong Chen, Jin-Shang Wu, Yin-Fan Chang, Chih-Ting Lee, Chih-Hsing Wu, Nai-Jung Chiang, Hsin-En Huang, Chia-Jui Yen, Ying-Jui Chao, Hui-Jen Tsai, Chiung-Yu Chen, Jui-Wen Kang, Chin-Fu Kuo, Chia-Rung Tsai, Ya-Ling Weng…

    Citation: Journal of Biomedical Science 2020 27:69

    Content type: Research

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  15. Tissue oxidative stress, sympathetic activation and nutrient sensing signals are closely related to adult hypertension of fetal origin, although their interactions in hypertension programming remain unclear. B...

    Authors: Yung-Mei Chao, Kay L. H. Wu, Pei-Chia Tsai, You-Lin Tain, Steve Leu, Wei-Chia Lee and Julie Y. H. Chan

    Citation: Journal of Biomedical Science 2020 27:68

    Content type: Research

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  16. Over the last 4 decades, cell culture techniques have evolved towards the creation of in vitro multicellular entities that incorporate the three-dimensional complexity of in vivo tissues and organs. As a resul...

    Authors: Alejandra Vargas-Valderrama, Antonietta Messina, Maria Teresa Mitjavila-Garcia and Hind Guenou

    Citation: Journal of Biomedical Science 2020 27:67

    Content type: Review

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  17. Rotaviruses (RVs) are recognized as a major cause of acute gastroenteritis (AGE) in infants and young children worldwide. Here we summarize the virology, disease burden, prevalence, distribution of genotypes a...

    Authors: Fajar Budi Lestari, Sompong Vongpunsawad, Nasamon Wanlapakorn and Yong Poovorawan

    Citation: Journal of Biomedical Science 2020 27:66

    Content type: Review

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  18. Hepatitis D virus (HDV) infection may induce fulminant hepatitis in chronic hepatitis B patients (CHB) or rapid progression of CHB to cirrhosis or hepatocellular carcinoma. There is no effective treatment for ...

    Authors: Yuh-Jin Liang, Cheng-Pu Sun, Yu-Chen Hsu, Yi-Wen Chen, I-An Wang, Chien-Wei Su, Mi-Hua Tao and Jaw-Ching Wu

    Citation: Journal of Biomedical Science 2020 27:65

    Content type: Research

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  19. Oxygen is essentially required by most eukaryotic organisms as a scavenger to remove harmful electron and hydrogen ions or as a critical substrate to ensure the proper execution of enzymatic reactions. All nuc...

    Authors: Pai-Sheng Chen, Wen-Tai Chiu, Pei-Ling Hsu, Shih-Chieh Lin, I-Chen Peng, Chia-Yih Wang and Shaw-Jenq Tsai

    Citation: Journal of Biomedical Science 2020 27:63

    Content type: Review

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  20. Cerebral arteriovenous malformation (AVM) is a serious life-threatening congenital cerebrovascular disease. Specific anatomical features, such as nidus size, location, and venous drainage, have been validated ...

    Authors: Lin-jian Wang, Yimeng Xue, Ran Huo, Zihan Yan, Hongyuan Xu, Hao Li, Jia Wang, Qian Zhang, Yong Cao and Ji-zong Zhao

    Citation: Journal of Biomedical Science 2020 27:62

    Content type: Research

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  21. The disruption of the blood–brain barrier (BBB) plays a critical event in the pathogenesis of ischemia stroke. TGR5 is recognized as a potential target for the treatment for neurologic disorders.

    Authors: Hui Liang, Nathanael Matei, Devin W. McBride, Yang Xu, Jiping Tang, Benyan Luo and John H. Zhang

    Citation: Journal of Biomedical Science 2020 27:61

    Content type: Research

    Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2020 27:71

  22. Columbianadin (CBN) is one of the main coumarin constituents isolated from Angelica pubescens. The pharmacological value of CBN is well demonstrated, especially in the prevention of several cancers and analgesic ...

    Authors: Shaw-Min Hou, Chih-Wei Hsia, Cheng-Lin Tsai, Chih-Hsuan Hsia, Thanasekaran Jayakumar, Marappan Velusamy and Joen-Rong Sheu

    Citation: Journal of Biomedical Science 2020 27:60

    Content type: Research

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  23. Over the past few years, long non-coding RNAs (lncRNAs) are recognized as key regulators of gene expression at chromatin, transcriptional and posttranscriptional level with pivotal roles in various biological ...

    Authors: Tse-Chun Kuo, Hsing-Jien Kung and Jing-Wen Shih

    Citation: Journal of Biomedical Science 2020 27:59

    Content type: Review

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  24. Short-term fasting (STF) is a technique to reduce nutrient intake for a specific period. Since metabolism plays a pivotal role in tumor progression, it can be hypothesized that STF can improve the efficacy of ...

    Authors: Jing Zhang, Yanlin Deng and Bee Luan Khoo

    Citation: Journal of Biomedical Science 2020 27:58

    Content type: Review

    Published on:

  25. O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a type of glycosylation that occurs when a monosaccharide, O-GlcNAc, is added onto serine or threonine residues of nuclear or cytoplasmic proteins by O-GlcN...

    Authors: Yi-Hsuan Chang, Chia-Lin Weng and Kuo-I Lin

    Citation: Journal of Biomedical Science 2020 27:57

    Content type: Review

    Published on:

  26. Human keratinocytes and derived products are crucial for skin repair and regeneration. Despite substantial advances in engineered skin equivalents, their poor availability and immunorejection remain major chal...

    Authors: Jie Zheng, Wonjin Yun, Junghyun Park, Phil Jun Kang, Gilju Lee, Gwonhwa Song, In Yong Kim and Seungkwon You

    Citation: Journal of Biomedical Science 2020 27:56

    Content type: Research

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  27. Very few studies have identified receptor molecules for dengue virus (DENV) on neural cells. This study was designed to identify putative receptor/(s) involved in entry of DENV-3 in human neural cells of vario...

    Authors: Amita Sharma, Ravi Vasanthapuram, Manjunatha M Venkataswamy and Anita Desai

    Citation: Journal of Biomedical Science 2020 27:55

    Content type: Research

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  28. Radiographic axial spondyloarthritis (r-axSpA) is a chronic inflammatory form of arthritis in which tumor necrosis factor (TNF)-α, a potent inducer of inflammatory response and a key regulator of innate immuni...

    Authors: Patricia Ruiz-Limon, Maria Lourdes Ladehesa-Pineda, Maria del Carmen Castro-Villegas, Maria del Carmen Abalos-Aguilera, Clementina Lopez-Medina, Chary Lopez-Pedrera, Nuria Barbarroja, Daniel Espejo-Peralbo, Jose Antonio Gonzalez-Reyes, Jose Manuel Villalba, Carlos Perez-Sanchez, Alejandro Escudero-Contreras, Eduardo Collantes-Estevez, Pilar Font-Ugalde and Yolanda Jimenez-Gomez

    Citation: Journal of Biomedical Science 2020 27:54

    Content type: Research

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  29. Enterovirus A71 (EV-A71) is one of the causative pathogens of hand, foot, and mouth disease (HFMD), which may cause severe neurological and cardiopulmonary complications in children. In this review, we discuss...

    Authors: Shao-Hsuan Hsia, Jainn-Jim Lin, Oi-Wa Chan and Tzou-Yien Lin

    Citation: Journal of Biomedical Science 2020 27:53

    Content type: Review

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  30. Alveologenesis is the final stage of lung development to form air-exchanging units between alveoli and blood vessels. Genetic susceptibility or hyperoxic stress to perturb this complicated process can cause ab...

    Authors: Yen-Ting Lai, Hsu-Wen Chao, Alan Chuan-Ying Lai, Shu-Hui Lin, Ya-Jen Chang and Yi-Shuian Huang

    Citation: Journal of Biomedical Science 2020 27:52

    Content type: Research

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  31. The emergence of Zika virus (ZV) in tropical and subtropical areas of the world has created an urgent need for vaccines against ZV. However, approved vaccines that prevent ZV infection are not available. To de...

    Authors: Mei-Yu Chen, Kit Man Chai, Chen-Yi Chiang, Chiao-Chieh Wu, Guann-Yi Yu, Shih-Jen Liu and Hsin-Wei Chen

    Citation: Journal of Biomedical Science 2020 27:51

    Content type: Research

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  32. The association of functionality and phenotype of follicular helper T cells (Tfh) with dengue virus (DENV) specific antibody responses and clinical disease severity has not been well studied.

    Authors: Ayesha Wijesinghe, Jayani Gamage, Hemantha Goonewardena, Laksiri Gomes, Deshni Jayathilaka, Dulharie T. Wijeratne, Ruklanthi de Alwis, Chandima Jeewandara, Ananda Wijewickrama, Graham S. Ogg and Gathsaurie Neelika Malavige

    Citation: Journal of Biomedical Science 2020 27:50

    Content type: Research

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  33. With the advances in deep sequencing-based transcriptome profiling technology, it is now known that human genome is transcribed more pervasively than previously thought. Up to 90% of the human DNA is transcrib...

    Authors: Chih-Fan Yeh, Yu-Chen Eugene Chang, Cheng-Yuan Lu, Chin-Feng Hsuan, Wei-Tien Chang and Kai-Chien Yang

    Citation: Journal of Biomedical Science 2020 27:48

    Content type: Review

    Published on:

  34. Influenza vaccine manufacturers traditionally use egg-derived candidate vaccine viruses (CVVs) to produce high-yield influenza viruses for seasonal or pandemic vaccines; however, these egg-derived CVVs need an...

    Authors: Tsai-Teng Tzeng, Po-Ling Chen, Tsai-Chuan Weng, Shin-Yi Tsai, Chia-Chun Lai, Hsin-I Chou, Pin-Wen Chen, Chia-Chun Lu, Ming-Tsan Liu, Wang-Chou Sung, Min-Shi Lee and Alan Yung-Chih Hu

    Citation: Journal of Biomedical Science 2020 27:47

    Content type: Research

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  35. Epigenetic silencing of retinoic acid (RA) signaling-related genes have been linked with the pathogenesis and clinical outcome in oral squamous cell carcinoma (OSCC) carcinogenesis. However, the precise mechan...

    Authors: Shine-Gwo Shiah, Jenn-Ren Hsiao, Hsiao-Ju Chang, Yuan-Ming Hsu, Guan-Hsun Wu, Hsuan-Yu Peng, Sung-Tau Chou, Ching-Chuan Kuo and Jang-Yang Chang

    Citation: Journal of Biomedical Science 2020 27:46

    Content type: Research

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  36. Human platelets (PLT) and PLT-extracellular vesicles (PEV) released upon thrombin activation express receptors that interact with tumour cells and, thus, can serve as a delivery platform of anti-cancer agents....

    Authors: Yu-Wen Wu, Cheng-Chain Huang, Chun Austin Changou, Long-Sheng Lu, Hadi Goubran and Thierry Burnouf

    Citation: Journal of Biomedical Science 2020 27:45

    Content type: Research

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  37. Stem cell activity is subject to non-cell-autonomous regulation from the local microenvironment, or niche. In adaption to varying physiological conditions and the ever-changing external environment, the stem c...

    Authors: Chih-Lung Chen, Wen-Yen Huang, Eddy Hsi Chun Wang, Kang-Yu Tai and Sung-Jan Lin

    Citation: Journal of Biomedical Science 2020 27:43

    Content type: Review

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  38. The underlying mechanism involved in ovarian cancer stemness and chemoresistance remains largely unknown. Here, we explored whether the regulation of c-Kit and plasma membrane prohibitin (PHB) affects ovarian ...

    Authors: Chia-Hsun Fang, Yi-Te Lin, Chi-Ming Liang and Shu-Mei Liang

    Citation: Journal of Biomedical Science 2020 27:42

    Content type: Research

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  39. Kaposi’s sarcoma-associated herpesvirus (KSHV), also designated human herpesvirus 8 (HHV-8), has been linked to Kaposi’s sarcoma, as well as to primary effusion lymphoma (PEL), and a subset of multicentric Cas...

    Authors: Mel Campbell and Yoshihiro Izumiya

    Citation: Journal of Biomedical Science 2020 27:41

    Content type: Review

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  40. The present study aimed to verify whether long noncoding RNA (lncRNA) MALAT1 is involved in brain tissue damage induced by ischemia-reperfusion injury, and to explore the mechanism by which MALAT1 regulates aquap...

    Authors: Hongwei Wang, Xiaoxiao Zheng, Jing Jin, Li Zheng, Ting Guan, Yangfan Huo, Shufen Xie, Ying Wu and Wei Chen

    Citation: Journal of Biomedical Science 2020 27:40

    Content type: Research

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  41. Aerobically-grown bacteria can be challenged by hydrogen peroxide stress from endogenous aerobic metabolism and exogenously generated reactive oxygen species. Catalase (Kat), alkyl hydroperoxidase (Ahp), and g...

    Authors: Li-Hua Li, Yung-Luen Shih, Jing-Yun Huang, Chao-Jung Wu, Yi-Wei Huang, Hsin-Hui Huang, Yu-Chieh Tsai and Tsuey-Ching Yang

    Citation: Journal of Biomedical Science 2020 27:37

    Content type: Research

    Published on:

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