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  1. Content type: Review

    Parkinson’s disease (PD) is the most common movement disorder and manifests as resting tremor, rigidity, bradykinesia, and postural instability. Pathologically, PD is characterized by selective loss of dopamin...

    Authors: Meng-Ling Chen and Ruey-Meei Wu

    Citation: Journal of Biomedical Science 2018 25:52

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  2. Content type: Review

    Next-generation sequencing (NGS) is a powerful and high-throughput method for the detection of viral mutations. This article provides a brief overview about optimization of NGS analysis for hepatocellular carc...

    Authors: I-Chin Wu, Wen-Chun Liu and Ting-Tsung Chang

    Citation: Journal of Biomedical Science 2018 25:51

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  3. Content type: Research

    Kisspeptin is involved in female reproduction. This study was designed to i- estimate kisspeptin levels in women with polycystic ovary syndrome (PCOS), in comparison with controls, ii- study the correlations b...

    Authors: Fadwa S. Albalawi, Maha H. Daghestani, Mazin H. Daghestani, Abdelmoneim Eldali and Arjumand S. Warsy

    Citation: Journal of Biomedical Science 2018 25:50

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  4. Content type: Review

    Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors. Best known for its role in transducing signals link...

    Authors: Robert F. Hillary and Una FitzGerald

    Citation: Journal of Biomedical Science 2018 25:48

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  5. Content type: Research

    Few studies have examined the relationship between the amounts of heavy metal and stroke incidence. The aim of this study was to explore the relationship between levels of heavy metals, including Pb, Hg, As, a...

    Authors: Ching-Huang Lin, Yi-Ting Hsu, Cheng-Chung Yen, Hsin-Hung Chen, Ching-Jiunn Tseng, Yuk-Keung Lo and Julie Y. H. Chan

    Citation: Journal of Biomedical Science 2018 25:49

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  6. Content type: Research

    Middle East respiratory syndrome coronavirus (MERS-CoV) consists of a positive-sense, single-stranded RNA genome and four structural proteins: the spike, envelope, membrane, and nucleocapsid protein. The assem...

    Authors: Wei-Chen Hsin, Chan-Hua Chang, Chi-You Chang, Wei-Hao Peng, Chung-Liang Chien, Ming-Fu Chang and Shin C. Chang

    Citation: Journal of Biomedical Science 2018 25:47

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  7. Content type: Research

    Lead (Pb2+) is an environmental neurotoxicant that disrupts neurodevelopment, communication, and organization through competition with Ca2+ signaling. How perinatal Pb2+ exposure affects Ca2+-related gene regulat...

    Authors: Lorenz S. Neuwirth, Greg R. Phillips and Abdeslem El Idrissi

    Citation: Journal of Biomedical Science 2018 25:45

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  8. Content type: Review

    The Myristoylated Alanine-Rich C-kinase Substrate (MARCKS) and MARCKS-like protein 1 (MARCKSL1) have a wide range of functions, ranging from roles in embryonic development to adult brain plasticity and the inf...

    Authors: Mohamed El Amri, Una Fitzgerald and Gerhard Schlosser

    Citation: Journal of Biomedical Science 2018 25:43

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  9. Content type: Research

    Transmembrane Ca2+ influx is critical for molecular rhythmicity, metabolic activity, and neuropeptide release in the central clock of the suprachiasmatic nucleus (SCN). We previously reported that both the Na+/Ca

    Authors: Pi-Cheng Cheng, Yi-Chi Wang, Ya-Shuan Chen, Ruo-Ciao Cheng, Jyh-Jeen Yang and Rong-Chi Huang

    Citation: Journal of Biomedical Science 2018 25:44

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  10. Content type: Research

    Fibroblast growth factor (FGF)-2 plays a crucial role in the pathophysiology of cardiovascular diseases (CVDs). FGF-2 was reported to induce cardiac hypertrophy through activation of FGF receptor 1 (FGFR1). Mu...

    Authors: Ting-Wei Lee, Ting-I Lee, Yung-Kuo Lin, Yu-Hsun Kao and Yi-Jen Chen

    Citation: Journal of Biomedical Science 2018 25:42

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  11. Content type: Research

    Cholinergic hypothesis of Alzheimer’s disease (AD) is based on the findings that a reduced and/or perturbed cholinergic activity in the central nervous system correlates with cognitive decline in patients with...

    Authors: Alice Hálová, Jana Janoutová, Laura Ewerlingová, Vladimír Janout, Ondřej Bonczek, Tomáš Zeman, Tereza Gerguri, Vladimir J. Balcar and Omar Šerý

    Citation: Journal of Biomedical Science 2018 25:41

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  12. Content type: Research

    Second generation antipsychotics (SGAs) induce glucometabolic side-effects, such as hyperglycemia and insulin resistance, which pose a therapeutic challenge for mental illness. Sphingolipids play a role in gly...

    Authors: Katrina Weston-Green, Ilijana Babic, Michael de Santis, Bo Pan, Magdalene K. Montgomery, Todd Mitchell, Xu-Feng Huang and Jessica Nealon

    Citation: Journal of Biomedical Science 2018 25:40

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  13. Content type: Research

    Whether hepatic progenitor cells (HPCs)/oval cells regenerate liver mass upon chronic liver injury is controversial in mice and has not been conclusively proven in humans and rats. In this study, we examined w...

    Authors: Chin-Sung Chien, Ya-Hui Chen, Hui-Ling Chen, Chiu-Ping Wang, Shang-Hsin Wu, Shu-Li Ho, Wen-Cheng Huang, Chun-Hsien Yu and Mei-Hwei Chang

    Citation: Journal of Biomedical Science 2018 25:39

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  14. Content type: Review

    Millions of people around the world suffer from bone disorders, likes osteoporosis, rheumatoid arthritis (RA), and cancer-induced osteolysis. In general, the bone remodeling balance is determined by osteoclast...

    Authors: Hsiao-Hsuan Wang, Yu-Hsiang Hsu and Ming-Shi Chang

    Citation: Journal of Biomedical Science 2018 25:38

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  15. Content type: Review

    Mammalian ovary contains millions of germ cells during embryonic life but only few of them are culminated into oocytes that achieve meiotic competency just prior to ovulation. The majority of germ cells are de...

    Authors: Pramod K. Yadav, Meenakshi Tiwari, Anumegha Gupta, Alka Sharma, Shilpa Prasad, Ashutosh N. Pandey and Shail K. Chaube

    Citation: Journal of Biomedical Science 2018 25:36

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  16. Content type: Review

    The pathogenesis of systemic autoimmune diseases such as systemic lupus erythematosus (SLE) is based on the loss of self-tolerance against ubiquitous autoantigens involving all mechanisms of adaptive immunity....

    Authors: Satish Kumar Devarapu and Hans-Joachim Anders

    Citation: Journal of Biomedical Science 2018 25:35

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  17. Content type: Research

    SP110, an interferon-induced nuclear protein, belongs to the SP100/SP140 protein family. Very recently, we showed that SP110b, an SP110 isoform, controls host innate immunity to Mycobacterium tuberculosis infecti...

    Authors: Jia-Shiun Leu, So-Yi Chang, Chia-Yu Mu, Mei-Ling Chen and Bo-Shiun Yan

    Citation: Journal of Biomedical Science 2018 25:34

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  18. Content type: Research

    Current influenza vaccines are mainly strain-specific and have limited efficacy in preventing new, potentially pandemic, influenza strains. Efficient control of influenza A infection can potentially be achieve...

    Authors: Liudmila A. Stepanova, Eugenia S. Mardanova, Marina A. Shuklina, Elena A. Blokhina, Roman Y. Kotlyarov, Marina V. Potapchuk, Anna A. Kovaleva, Inna G. Vidyaeva, Alexandr V. Korotkov, Elizaveta I. Eletskaya, Nikolai V. Ravin and Liudmila M. Tsybalova

    Citation: Journal of Biomedical Science 2018 25:33

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  19. Content type: Research

    During metastasis, cancer cells require anokis resistant mechanism to survive until reach the distant secondary tissues. As anoikis sensitization may benefit for cancer therapy, this study demonstrated the pot...

    Authors: Arisara Prateep, Somruethai Sumkhemthong, Wiranpat Karnsomwan, Wanchai De-Eknamkul, Supakarn Chamni, Pithi Chanvorachote and Chatchai Chaotham

    Citation: Journal of Biomedical Science 2018 25:32

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  20. Content type: Review

    Nasopharyngeal carcinoma (NPC) is a head and neck cancer with poor clinical outcomes and insufficient treatments in Southeast Asian populations. Although concurrent chemoradiotherapy has improved recovery rate...

    Authors: Chang-Yu Chen, Yung-Song Lin, Chien-Ho Chen and Yin-Ju Chen

    Citation: Journal of Biomedical Science 2018 25:30

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  21. Content type: Review

    Advances in Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated system (CRISPR/Cas9) has dramatically reshaped our ability to edit genomes. The scientific community is using CRISPR/Cas9...

    Authors: Sehrish Khan, Muhammad Shahid Mahmood, Sajjad ur Rahman, Hassan Zafar, Sultan Habibullah, Zulqarnain khan and Aftab Ahmad

    Citation: Journal of Biomedical Science 2018 25:29

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  22. Content type: Research

    β-aminoisobutyric acid (BAIBA) is produced in skeletal muscle during exercise and has beneficial effects on obesity-related metabolic disorders such as diabetes and non-alcoholic fatty liver disease. Thus, it ...

    Authors: Tae Woo Jung, Hyung Sub Park, Geum Hee Choi, Daehwan Kim and Taeseung Lee

    Citation: Journal of Biomedical Science 2018 25:27

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