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  1. Long non-coding RNAs (lncRNAs) are pivotal players in cellular processes, and their unique cell-type specific expression patterns render them attractive biomarkers and therapeutic targets. Yet, the functional ...

    Authors: Joshua M. Hazan, Raziel Amador, Tahleel Ali-Nasser, Tamar Lahav, Stav Roni Shotan, Miryam Steinberg, Ziv Cohen, Dvir Aran, David Meiri, Yehuda G. Assaraf, Roderic Guigó and Assaf C. Bester
    Citation: Journal of Biomedical Science 2024 31:27
  2. Streptococcus pyogenes (group A streptococcus, GAS) causes a variety of diseases ranging from mild superficial infections of the throat and skin to severe invasive infections, such as necrotizing soft tissue infe...

    Authors: Lea A. Tölken, Antje D. Paulikat, Lana H. Jachmann, Alexander Reder, Manuela Gesell Salazar, Laura M. Palma Medina, Stephan Michalik, Uwe Völker, Mattias Svensson, Anna Norrby-Teglund, Katharina J. Hoff, Michael Lammers and Nikolai Siemens
    Citation: Journal of Biomedical Science 2024 31:26
  3. Breast cancer is one of the most common malignancies that pose a serious threat to women's health. Reprogramming of energy metabolism is a major feature of the malignant transformation of breast cancer. Compar...

    Authors: Shiliang Xu, Lingxia Wang, Yuexin Zhao, Tong Mo, Bo Wang, Jun Lin and Huan Yang
    Citation: Journal of Biomedical Science 2024 31:25
  4. Mutations in CHCHD2 have been linked to Parkinson’s disease, however, their exact pathophysiologic roles are unclear. The p32 protein has been suggested to interact with CHCHD2, however, the physiological functio...

    Authors: Murni Tio, Rujing Wen, Cai Ning Choo, Jian Bin Tan, Aaron Chua, Bin Xiao, Jeyapriya Rajameenakshi Sundaram, Christine Hui Shan Chan and Eng-King Tan
    Citation: Journal of Biomedical Science 2024 31:24
  5. Pregnancy associated plasma protein-A (PAPP-A) plays an integral role in breast cancer (BC), especially triple negative breast cancer (TNBC). This subtype accounts for the most aggressive BC, possesses high tu...

    Authors: Arpita Poddar, Farah Ahmady, Sushma R. Rao, Revati Sharma, George Kannourakis, Prashanth Prithviraj and Aparna Jayachandran
    Citation: Journal of Biomedical Science 2024 31:23
  6. Cancer susceptibility germline mutations are associated with pancreatic ductal adenocarcinoma (PDAC). However, the hereditary status of PDAC and its impact on survival is largely unknown in the Asian population.

    Authors: Siao Muk Cheng, Yung-Yeh Su, Nai-Jung Chiang, Chih-Jung Wang, Ying-Jui Chao, Chien-Jui Huang, Hui-Jen Tsai, Shang-Hung Chen, Chi-Yen Chang, Chia-Rung Tsai, Yi-Jie Li, Chia-Jui Yen, Shih-Chang Chuang, Jeffrey Shu-Ming Chang, Yan-Shen Shan, Daw-Yang Hwang…
    Citation: Journal of Biomedical Science 2024 31:21
  7. Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor expressed on the surface of T cells. High expression of PD-1 leads to T-cell dysfunction in the tumor microenvironment (TME). However, th...

    Authors: Wan-Ting Kuo, I-Ying Kuo, Hung-Chia Hsieh, Ssu-Ting Wu, Wu-Chou Su and Yi-Ching Wang
    Citation: Journal of Biomedical Science 2024 31:20
  8. Previous research in FMS-like tyrosine kinase 3 ligands (FLT3L) has primarily focused on their potential to generate dendritic cells (DCs) from bone marrow progenitors, with a limited understanding of how thes...

    Authors: Hsin-Fang Tu, Yu-Jui Kung, Ling Lim, Julia Tao, Ming-Hung Hu, Michelle Cheng, Deyin Xing, T. C. Wu and Chien-Fu Hung
    Citation: Journal of Biomedical Science 2024 31:19
  9. Mycobacterium abscessus, a fast-growing non-tuberculous mycobacterium, is an emerging opportunistic pathogen responsible for chronic bronchopulmonary infections in people with respiratory diseases such as cystic ...

    Authors: Magali Casanova, Marc Maresca, Isabelle Poncin, Vanessa Point, Hamza Olleik, Céline Boidin-Wichlacz, Aurélie Tasiemski, Kamel Mabrouk, Jean-François Cavalier and Stéphane Canaan
    Citation: Journal of Biomedical Science 2024 31:18
  10. MDM2 has been established as a biomarker indicating poor prognosis for individuals undergoing immune checkpoint inhibitor (ICI) treatment for different malignancies by various pancancer studies. Specifically, ...

    Authors: Dantong Sun, Haili Qian, Junling Li and Puyuan Xing
    Citation: Journal of Biomedical Science 2024 31:17
  11. CDGSH iron-sulfur domain-containing protein 2 (CISD2), a pro-longevity gene, mediates healthspan in mammals. CISD2 is down-regulated during aging. Furthermore, a persistently high level of CISD2 promotes longe...

    Authors: Zhao-Qing Shen, Cheng-Yen Chang, Chi-Hsiao Yeh, Chung-Kuang Lu, Hao-Chih Hung, Tai-Wen Wang, Kuan-Sheng Wu, Chien-Yi Tung and Ting-Fen Tsai
    Citation: Journal of Biomedical Science 2024 31:15
  12. The expression of aquaporin 4 (AQP4) and intermediate filament (IF) proteins is altered in malignant glioblastoma (GBM), yet the expression of the major IF-based cytolinker, plectin (PLEC), and its contributio...

    Authors: Maja Žugec, Borut Furlani, Maria J. Castañon, Boštjan Rituper, Irmgard Fischer, Giuseppe Broggi, Rosario Caltabiano, Giuseppe M. V. Barbagallo, Michelino Di Rosa, Daniele Tibullo, Rosalba Parenti, Nunzio Vicario, Saša Simčič, Victorio Martin Pozo Devoto, Gorazd B. Stokin, Gerhard Wiche…
    Citation: Journal of Biomedical Science 2024 31:14
  13. Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are l...

    Authors: Daniel B. Rodrigues, Rui L. Reis and Rogério P. Pirraco
    Citation: Journal of Biomedical Science 2024 31:13
  14. Pathologic scars, including keloids and hypertrophic scars, represent a common form of exaggerated cutaneous scarring that is difficult to prevent or treat effectively. Additionally, the pathobiology of pathol...

    Authors: Yi-Kai Hong, Yu-Chen Lin, Tsung-Lin Cheng, Chao-Han Lai, Yi-Han Chang, Yu-Lun Huang, Chia-Yi Hung, Chen-Han Wu, Kuo-Shu Hung, Ya-Chu Ku, Yen-Ting Ho, Ming-Jer Tang, Shu-Wha Lin, Guey-Yueh Shi, John A. McGrath, Hua-Lin Wu…
    Citation: Journal of Biomedical Science 2024 31:12
  15. Liquid–liquid phase separation (LLPS) in biology describes a process by which proteins form membraneless condensates within a cellular compartment when conditions are met, including the concentration and postt...

    Authors: Fangfang Wang and Youwei Zhang
    Citation: Journal of Biomedical Science 2024 31:11
  16. The tumor microenvironment is characterized by inflammation-like and immunosuppression situations. Although cancer-associated fibroblasts (CAFs) are among the major stromal cell types in various solid cancers,...

    Authors: Feng-Wei Chen, Yung-Ling Wu, Chao-Chun Cheng, Yu-Wei Hsiao, Jhih-Ying Chi, Liang-Yi Hung, Chih-Peng Chang, Ming-Derg Lai and Ju-Ming Wang
    Citation: Journal of Biomedical Science 2024 31:10
  17. Chikungunya virus (CHIKV) has reemerged as a major public health concern, causing chikungunya fever with increasing cases and neurological complications.

    Authors: Huixin Chen, Patchara Phuektes, Li Sze Yeo, Yi Hao Wong, Regina Ching Hua Lee, Bowen Yi, Xinjun Hou, Sen Liu, Yu Cai and Justin Jang Hann Chu
    Citation: Journal of Biomedical Science 2024 31:8
  18. Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional two-dimensional (2D) cell culture systems. In 3D cell cultures, cancer c...

    Authors: Waad H. Abuwatfa, William G. Pitt and Ghaleb A. Husseini
    Citation: Journal of Biomedical Science 2024 31:7
  19. The developments of antibodies for cancer therapeutics have made remarkable success in recent years. There are multiple factors contributing to the success of the biological molecule including origin of the an...

    Authors: Mukesh Kumar, Akansha Jalota, Sushil Kumar Sahu and Shabirul Haque
    Citation: Journal of Biomedical Science 2024 31:6
  20. Metabolic remodeling and changes in tumor immune microenvironment (TIME) in osteosarcoma are important factors affecting prognosis and treatment. However, the relationship between metabolism and TIME needs to ...

    Authors: Changwu Wu, Jun Tan, Hong Shen, Chao Deng, Christian Kleber, Georg Osterhoff and Nikolas Schopow
    Citation: Journal of Biomedical Science 2024 31:4
  21. During sepsis, serve vascular dysfunctions lead to life-threatening multiple organ failure, due to vascular smooth muscle cells (VSMC) impairments, resulting in vasoplegia, hypotension and hypoperfusion. In ad...

    Authors: Philipp Terpe, Stefanie Ruhs, Virginie Dubourg, Michael Bucher and Michael Gekle
    Citation: Journal of Biomedical Science 2024 31:3
  22. Excessive lipid accumulation in the adipose tissue in obesity alters the endocrine and energy storage functions of adipocytes. Adipocyte lipid droplets represent key organelles coordinating lipid storage and m...

    Authors: Jaime López-Alcalá, Ana Gordon, Andrés Trávez, Carmen Tercero-Alcázar, Alejandro Correa-Sáez, María Jesús González-Rellán, Oriol A. Rangel-Zúñiga, Amaia Rodríguez, Antonio Membrives, Gema Frühbeck, Rubén Nogueiras, Marco A. Calzado, Rocío Guzmán-Ruiz and María M. Malagón
    Citation: Journal of Biomedical Science 2024 31:2
  23. As of 2020, hepatocellular carcinoma (HCC), a form of liver cancer, stood as the third most prominent contributor to global cancer-related mortality. Combining immune checkpoint inhibitors (ICI) with other the...

    Authors: Da-Liang Ou, Zi-Xian Liao, Ivan M. Kempson, Lin Li, Pan-Chyr Yang and S.-Ja Tseng
    Citation: Journal of Biomedical Science 2024 31:1
  24. Human enteroviruses A71 (EV-A71) and D68 (EV-D68) are the suspected causative agents of hand-foot-and-mouth disease, aseptic meningitis, encephalitis, acute flaccid myelitis, and acute flaccid paralysis in chi...

    Authors: Yu-Li Lin, Pei-Yun Cheng, Chiao-Li Chin, Kuan-Ting Chuang, Jing-Yi Lin, Ning Chang, Chun-Kei Pan, Cheng-Sheng Lin, Siao-Cian Pan and Bor-Luen Chiang
    Citation: Journal of Biomedical Science 2023 30:96
  25. Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), and its pathogenicity is associated with its ability to evade the host defense system. The secretory form of the chorismate mutase of M. tub...

    Authors: Mi-Hyun Lee, Hye Lin Kim, Hyejun Seo, Sangkwon Jung and Bum-Joon Kim
    Citation: Journal of Biomedical Science 2023 30:95
  26. ARID1A, a tumor suppressor gene encoding BAF250, a protein participating in chromatin remodeling, is frequently mutated in endometrium-related malignancies, including ovarian or uterine clear cell carcinoma (CCC)...

    Authors: Jayaprakash Mandal, Zheng-Cheng Yu, Ie-Ming Shih and Tian-Li Wang
    Citation: Journal of Biomedical Science 2023 30:94
  27. Patients with metastatic triple-negative breast cancer (mTNBC) have a higher probability of developing visceral metastasis within 5 years after the initial diagnosis. Therefore, a deeper understanding of the p...

    Authors: Shih-Hsuan Chan, Wen-Hung Kuo and Lu-Hai Wang
    Citation: Journal of Biomedical Science 2023 30:93
  28. Psychological stress is a global issue that affects at least one-third of the population worldwide and increases the risk of numerous psychiatric disorders. Accumulating evidence suggests that the gut and its ...

    Authors: Tzu-Ting Lai, Chia-Wei Liou, Yu-Hsuan Tsai, Yuan-Yuan Lin and Wei-Li Wu
    Citation: Journal of Biomedical Science 2023 30:92
  29. Although stimulating autophagy caused by UV has been widely demonstrated in skin cells to exert cell protection, it remains unknown the cellular events in UVA-treated retinal pigment epithelial (RPE) cells.

    Authors: Anthony Yan-Tang Wu, Ponarulselvam Sekar, Duen-Yi Huang, Shu-Hao Hsu, Chi-Ming Chan and Wan-Wan Lin
    Citation: Journal of Biomedical Science 2023 30:91
  30. The NLRP3 inflammasome is an intracellular sensor and an essential component of the innate immune system involved in danger recognition. An important hallmark of inflammasome activation is the formation of a s...

    Authors: Valentina Arrè, Rosanna Scialpi, Matteo Centonze, Gianluigi Giannelli, Maria Principia Scavo and Roberto Negro
    Citation: Journal of Biomedical Science 2023 30:90
  31. RNA has emerged as a revolutionary and important tool in the battle against emerging infectious diseases, with roles extending beyond its applications in vaccines, in which it is used in the response to the CO...

    Authors: Hara Kang, Yun Ji Ga, Soo Hyun Kim, Young Hoon Cho, Jung Won Kim, Chaeyeon Kim and Jung-Yong Yeh
    Citation: Journal of Biomedical Science 2023 30:88
  32. Human angiotensin-converting enzyme 2 (hACE2) is the receptor mediating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. hACE2 expression is low in the lungs and is upregulated after SAR...

    Authors: Chao-Fu Yang, Chun-Che Liao, Hung-Wei Hsu, Jian-Jong Liang, Chih-Shin Chang, Hui-Ying Ko, Rue-Hsin Chang, Wei-Chun Tang, Ming-Hao Chang, I-Hsuan Wang and Yi-Ling Lin
    Citation: Journal of Biomedical Science 2023 30:87
  33. mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class will promise to develop methods for safely delivering the bioactive agents with high e...

    Authors: Yu-Shiuan Wang, Monika Kumari, Guan-Hong Chen, Ming-Hsiang Hong, Joyce Pei-Yi Yuan, Jui-Ling Tsai and Han-Chung Wu
    Citation: Journal of Biomedical Science 2023 30:84
  34. The induction of a cells destiny is a tightly controlled process that is regulated through communication between the matrix and cell signalling proteins. Cell signalling activates distinctive subsections of ta...

    Authors: Sandy Winfield Jere, Heidi Abrahamse and Nicolette Nadene Houreld
    Citation: Journal of Biomedical Science 2023 30:81
  35. Metastasis is a multistep process involving the migration and invasion of cancer cells and is a hallmark of cancer malignancy. Long non-coding RNAs (lncRNAs) play critical roles in the regulation of metastasis...

    Authors: Yi-Ling Chen, Yi-Nan Liu, Yen-Ting Lin, Meng-Feng Tsai, Shang-Gin Wu, Tzu-Hua Chang, Chia-Lang Hsu, Huey-Dong Wu and Jin-Yuan Shih
    Citation: Journal of Biomedical Science 2023 30:80
  36. Platelets are small anucleated blood cells primarily known for their vital hemostatic role. Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential cellular product transfused by ...

    Authors: Thierry Burnouf, Ming-Li Chou, David J. Lundy, Er-Yuan Chuang, Ching-Li Tseng and Hadi Goubran
    Citation: Journal of Biomedical Science 2023 30:79
  37. Dysregulated long noncoding RNA (lncRNA) expression with increased apoptosis has been demonstrated in systemic lupus erythematosus (SLE) patients with alveolar hemorrhage (AH). SNHG16, a lncRNA, can enhance pu...

    Authors: Yu-Tung Hsieh, Yi-Cheng Chen, Yu-Chi Chou, Pin‑Yu Kuo, Yi-Ting Yen, Hung-Wen Tsai and Chrong-Reen Wang
    Citation: Journal of Biomedical Science 2023 30:78
  38. Bioactive materials have now raised considerable attention for the treatment of osteoarthritis (OA), such as knee OA, rheumatoid OA, and temporomandibular joint (TMJ) OA. TMJ-OA is a common disease associated ...

    Authors: Bou-Yue Peng, Abhinay Kumar Singh, Ching-Yu Tsai, Chun-Hao Chan, Yue-Hua Deng, Chi-Ming Wu, Yen-Ru Chou, Wen Tsao, Chia-Yu Wu and Win-Ping Deng
    Citation: Journal of Biomedical Science 2023 30:77
  39. Stroke remains one of the leading causes of long-term disability worldwide, and the development of effective restorative therapies is hindered by an incomplete understanding of intrinsic brain recovery mechani...

    Authors: Egor Dzyubenko, Katrin I. Willig, Dongpei Yin, Maryam Sardari, Erdin Tokmak, Patrick Labus, Ben Schmermund and Dirk M. Hermann
    Citation: Journal of Biomedical Science 2023 30:76
  40. Klebsiella aerogenes can cause ventilator-associated pneumonia by forming biofilms, and it is frequently associated with multidrug resistance. Phages are good antibiotic alternatives with unique advantages. There...

    Authors: Xiaohu Cui, Bing Du, Junxia Feng, Yanling Feng, Zheng Fan, Jinfeng Chen, Jinghua Cui, Lin Gan, Tongtong Fu, Ziyan Tian, Rui Zhang, Chao Yan, Hanqing Zhao, Wenjian Xu, Ziying Xu, Zihui Yu…
    Citation: Journal of Biomedical Science 2023 30:75
  41. Electrical impulses from cardiac pacemaker cardiomyocytes initiate cardiac contraction and blood pumping and maintain life. Abnormal electrical impulses bring patients with low heart rates to cardiac arrest. T...

    Authors: Chih-Min Liu, Yi-Chun Chen and Yu-Feng Hu
    Citation: Journal of Biomedical Science 2023 30:74

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