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  1. Content type: Review

    Visceral pain is a complex and heterogeneous disorder, which can range from the mild discomfort of indigestion to the agonizing pain of renal colic. Regulation of visceral pain involves the spinal cord as well...

    Authors: Matteo M Pusceddu and Melanie G Gareau

    Citation: Journal of Biomedical Science 2018 25:73

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  2. Content type: Research

    Neurofibromatosis type 1 (NF1) is a dominantly inherited tumor predisposition syndrome that targets the peripheral nervous system. It is caused by mutations of the NF1 gene which serve as a negative regulator of ...

    Authors: Yah-Huei Wu-Chou, Tzu-Chao Hung, Yin-Ting Lin, Hsing-Wen Cheng, Ju-Li Lin, Chih-Hung Lin, Chung-Chih Yu, Kuo-Ting Chen, Tu-Hsueh Yeh and Yu-Ray Chen

    Citation: Journal of Biomedical Science 2018 25:72

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  3. Content type: Research

    Human papillomavirus (HPV) is the most common sexually transmitted virus in women worldwide. The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelia...

    Authors: Nádia Calvo Martins Okuyama, Fernando Cezar-dos-Santos, Érica Romão Pereira, Kleber Paiva Trugilo, Guilherme Cesar Martelossi Cebinelli, Michelle Mota Sena, Ana Paula Lombardi Pereira, Adriano Martin Felis Aranome, Luis Fernando Lasaro Mangieri, Rodolfo Sanches Ferreira, Maria Angelica Ehara Watanabe and Karen Brajão de Oliveira

    Citation: Journal of Biomedical Science 2018 25:69

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  4. Content type: Review

    Ubiquitination modulates a large repertoire of cellular functions and thus, dysregulation of the ubiquitin system results in multiple human diseases, including cancer. Ubiquitination requires an E3 ligase, whi...

    Authors: Shih-Han Kao, Han-Tsang Wu and Kou-Juey Wu

    Citation: Journal of Biomedical Science 2018 25:67

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  5. Content type: Review

    Helicobacter pylori infection is the principal cause of peptic ulcer disease, gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue lymphoma. Recent studies have shown that it may interfere with ma...

    Authors: Feng-Woei Tsay and Ping-I Hsu

    Citation: Journal of Biomedical Science 2018 25:65

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  6. Content type: Review

    Esophageal squamous cell carcinoma (ESCC) is the predominant subtype of esophageal cancer worldwide and highly prevalent in less developed regions. Management of ESCC is challenging and involves multimodal tre...

    Authors: Nikki P. Lee, Chung Man Chan, Lai Nar Tung, Hector K. Wang and Simon Law

    Citation: Journal of Biomedical Science 2018 25:66

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  7. Content type: Research

    B cells play an essential role during dengue viral infection. While a major expansion of antibody secreting cells (ASCs) was observed, the importance of these increased frequencies of ASCs remains unclear. The...

    Authors: Kovit Pattanapanyasat, Ladawan Khowawisetsut, Ampaiwan Chuansumrit, Kulkanya Chokephaibulkit, Kanchana Tangnararatchakit, Nopporn Apiwattanakul, Chonnamet Techasaensiri, Premrutai Thitilertdecha, Tipaporn Sae-Ung and Nattawat Onlamoon

    Citation: Journal of Biomedical Science 2018 25:64

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  8. Content type: Research

    Glioblastoma multiforme (GBM) is one of the lethal malignant tumors of the central nervous system. Despite advances made in understanding this complex disease, little has been achieved in improving clinical ef...

    Authors: Ira Sharma, Avninder Singh, Fouzia Siraj and Sunita Saxena

    Citation: Journal of Biomedical Science 2018 25:62

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  9. Content type: Review

    Studies at the molecular level aim to integrate genetic and neurobiological data to provide an increasingly detailed understanding of phenotypes related to the ability in time perception.

    Authors: Victor Marinho, Thomaz Oliveira, Juliete Bandeira, Giovanny R. Pinto, Anderson Gomes, Valéria Lima, Francisco Magalhães, Kaline Rocha, Carla Ayres, Valécia Carvalho, Bruna Velasques, Pedro Ribeiro, Marco Orsini, Victor Hugo Bastos, Daya Gupta and Silmar Teixeira

    Citation: Journal of Biomedical Science 2018 25:61

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  10. Content type: Research

    Cancer stem cells are capable of undergoing cell division after surviving cancer therapies, leading to tumor progression and recurrence. Inhibitory agents against cancer stem cells may be therapeutically used ...

    Authors: Chun-Chia Cheng, Po-Nien Liao, Ai-Sheng Ho, Ken-Hong Lim, Jungshan Chang, Ying-Wen Su, Caleb Gon-Shen Chen, Ya-Wen Chiang, Bi-Ling Yang, Huan-Chau Lin, Yu-Cheng Chang, Chun-Chao Chang and Yi-Fang Chang

    Citation: Journal of Biomedical Science 2018 25:60

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  11. Content type: Research

    Hepatitis B virus (HBV) infection is a common disease worldwide and is known to cause liver disease. C-type lectin 18 (CLEC18) is a novel secretory lectin highly expressed in human hepatocytes. Because the liv...

    Authors: Tsung-Yu Tsai, Cheng-Yuan Peng, Hwai-I Yang, Ya-Lang Huang, Mi-Hua Tao, Shin-Sheng Yuan, Hsueh-Chou Lai and Shie-Liang Hsieh

    Citation: Journal of Biomedical Science 2018 25:59

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  12. Content type: Research

    Induced pluripotency in cancer cells by ectopic expression of pluripotency-regulating factors may be used for disease modeling of cancers. MicroRNAs (miRNAs) are negative regulators of gene expression that pla...

    Authors: Michele Sook Yuin Hiew, Han Ping Cheng, Chiu-Jung Huang, Kowit Yu Chong, Soon Keng Cheong, Kong Bung Choo and Tunku Kamarul

    Citation: Journal of Biomedical Science 2018 25:57

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  13. Content type: Research

    Sepsis is a life-threatening disease mediated by profound disturbances in systemic inflammatory response to infection. IL-33 is multifunctional regulator of numerous aspects of innate and adaptive immune respo...

    Authors: Zivan M. Babic, Filip Z. Zunic, Jelena M. Pantic, Gordana D. Radosavljevic, Ivan P. Jovanovic, Nebojsa N. Arsenijevic and Miodrag L. Lukic

    Citation: Journal of Biomedical Science 2018 25:56

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  14. Content type: Research

    The nuclear translocation of epidermal growth factor receptor (EGFR) has been considered to play a role in carcinogenesis. However, the relevance of differentially located EGFR proteins in lung cancer remains ...

    Authors: Jinn-Li Wang, Chia-Lang Fang, Yu-Tien Tzeng, Han-Lin Hsu, Sey-En Lin, Ming-Chih Yu, Kuan-Jen Bai, Liang-Shun Wang and Hsingjin Eugene Liu

    Citation: Journal of Biomedical Science 2018 25:53

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  15. Content type: Review

    Parkinson’s disease (PD) is the most common movement disorder and manifests as resting tremor, rigidity, bradykinesia, and postural instability. Pathologically, PD is characterized by selective loss of dopamin...

    Authors: Meng-Ling Chen and Ruey-Meei Wu

    Citation: Journal of Biomedical Science 2018 25:52

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  16. Content type: Review

    Next-generation sequencing (NGS) is a powerful and high-throughput method for the detection of viral mutations. This article provides a brief overview about optimization of NGS analysis for hepatocellular carc...

    Authors: I-Chin Wu, Wen-Chun Liu and Ting-Tsung Chang

    Citation: Journal of Biomedical Science 2018 25:51

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  17. Content type: Research

    Kisspeptin is involved in female reproduction. This study was designed to i- estimate kisspeptin levels in women with polycystic ovary syndrome (PCOS), in comparison with controls, ii- study the correlations b...

    Authors: Fadwa S. Albalawi, Maha H. Daghestani, Mazin H. Daghestani, Abdelmoneim Eldali and Arjumand S. Warsy

    Citation: Journal of Biomedical Science 2018 25:50

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  18. Content type: Review

    Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors. Best known for its role in transducing signals link...

    Authors: Robert F. Hillary and Una FitzGerald

    Citation: Journal of Biomedical Science 2018 25:48

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  19. Content type: Research

    Few studies have examined the relationship between the amounts of heavy metal and stroke incidence. The aim of this study was to explore the relationship between levels of heavy metals, including Pb, Hg, As, a...

    Authors: Ching-Huang Lin, Yi-Ting Hsu, Cheng-Chung Yen, Hsin-Hung Chen, Ching-Jiunn Tseng, Yuk-Keung Lo and Julie Y. H. Chan

    Citation: Journal of Biomedical Science 2018 25:49

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  20. Content type: Research

    Middle East respiratory syndrome coronavirus (MERS-CoV) consists of a positive-sense, single-stranded RNA genome and four structural proteins: the spike, envelope, membrane, and nucleocapsid protein. The assem...

    Authors: Wei-Chen Hsin, Chan-Hua Chang, Chi-You Chang, Wei-Hao Peng, Chung-Liang Chien, Ming-Fu Chang and Shin C. Chang

    Citation: Journal of Biomedical Science 2018 25:47

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  21. Content type: Research

    Lead (Pb2+) is an environmental neurotoxicant that disrupts neurodevelopment, communication, and organization through competition with Ca2+ signaling. How perinatal Pb2+ exposure affects Ca2+-related gene regulat...

    Authors: Lorenz S. Neuwirth, Greg R. Phillips and Abdeslem El Idrissi

    Citation: Journal of Biomedical Science 2018 25:45

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  22. Content type: Review

    The Myristoylated Alanine-Rich C-kinase Substrate (MARCKS) and MARCKS-like protein 1 (MARCKSL1) have a wide range of functions, ranging from roles in embryonic development to adult brain plasticity and the inf...

    Authors: Mohamed El Amri, Una Fitzgerald and Gerhard Schlosser

    Citation: Journal of Biomedical Science 2018 25:43

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  23. Content type: Research

    Transmembrane Ca2+ influx is critical for molecular rhythmicity, metabolic activity, and neuropeptide release in the central clock of the suprachiasmatic nucleus (SCN). We previously reported that both the Na+/Ca

    Authors: Pi-Cheng Cheng, Yi-Chi Wang, Ya-Shuan Chen, Ruo-Ciao Cheng, Jyh-Jeen Yang and Rong-Chi Huang

    Citation: Journal of Biomedical Science 2018 25:44

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  24. Content type: Research

    Fibroblast growth factor (FGF)-2 plays a crucial role in the pathophysiology of cardiovascular diseases (CVDs). FGF-2 was reported to induce cardiac hypertrophy through activation of FGF receptor 1 (FGFR1). Mu...

    Authors: Ting-Wei Lee, Ting-I Lee, Yung-Kuo Lin, Yu-Hsun Kao and Yi-Jen Chen

    Citation: Journal of Biomedical Science 2018 25:42

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  25. Content type: Research

    Cholinergic hypothesis of Alzheimer’s disease (AD) is based on the findings that a reduced and/or perturbed cholinergic activity in the central nervous system correlates with cognitive decline in patients with...

    Authors: Alice Hálová, Jana Janoutová, Laura Ewerlingová, Vladimír Janout, Ondřej Bonczek, Tomáš Zeman, Tereza Gerguri, Vladimir J. Balcar and Omar Šerý

    Citation: Journal of Biomedical Science 2018 25:41

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  26. Content type: Research

    Second generation antipsychotics (SGAs) induce glucometabolic side-effects, such as hyperglycemia and insulin resistance, which pose a therapeutic challenge for mental illness. Sphingolipids play a role in gly...

    Authors: Katrina Weston-Green, Ilijana Babic, Michael de Santis, Bo Pan, Magdalene K. Montgomery, Todd Mitchell, Xu-Feng Huang and Jessica Nealon

    Citation: Journal of Biomedical Science 2018 25:40

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  27. Content type: Research

    Whether hepatic progenitor cells (HPCs)/oval cells regenerate liver mass upon chronic liver injury is controversial in mice and has not been conclusively proven in humans and rats. In this study, we examined w...

    Authors: Chin-Sung Chien, Ya-Hui Chen, Hui-Ling Chen, Chiu-Ping Wang, Shang-Hsin Wu, Shu-Li Ho, Wen-Cheng Huang, Chun-Hsien Yu and Mei-Hwei Chang

    Citation: Journal of Biomedical Science 2018 25:39

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  28. Content type: Review

    Millions of people around the world suffer from bone disorders, likes osteoporosis, rheumatoid arthritis (RA), and cancer-induced osteolysis. In general, the bone remodeling balance is determined by osteoclast...

    Authors: Hsiao-Hsuan Wang, Yu-Hsiang Hsu and Ming-Shi Chang

    Citation: Journal of Biomedical Science 2018 25:38

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  29. Content type: Review

    Mammalian ovary contains millions of germ cells during embryonic life but only few of them are culminated into oocytes that achieve meiotic competency just prior to ovulation. The majority of germ cells are de...

    Authors: Pramod K. Yadav, Meenakshi Tiwari, Anumegha Gupta, Alka Sharma, Shilpa Prasad, Ashutosh N. Pandey and Shail K. Chaube

    Citation: Journal of Biomedical Science 2018 25:36

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  30. Content type: Review

    The pathogenesis of systemic autoimmune diseases such as systemic lupus erythematosus (SLE) is based on the loss of self-tolerance against ubiquitous autoantigens involving all mechanisms of adaptive immunity....

    Authors: Satish Kumar Devarapu and Hans-Joachim Anders

    Citation: Journal of Biomedical Science 2018 25:35

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  31. Content type: Research

    SP110, an interferon-induced nuclear protein, belongs to the SP100/SP140 protein family. Very recently, we showed that SP110b, an SP110 isoform, controls host innate immunity to Mycobacterium tuberculosis infecti...

    Authors: Jia-Shiun Leu, So-Yi Chang, Chia-Yu Mu, Mei-Ling Chen and Bo-Shiun Yan

    Citation: Journal of Biomedical Science 2018 25:34

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  32. Content type: Research

    Current influenza vaccines are mainly strain-specific and have limited efficacy in preventing new, potentially pandemic, influenza strains. Efficient control of influenza A infection can potentially be achieve...

    Authors: Liudmila A. Stepanova, Eugenia S. Mardanova, Marina A. Shuklina, Elena A. Blokhina, Roman Y. Kotlyarov, Marina V. Potapchuk, Anna A. Kovaleva, Inna G. Vidyaeva, Alexandr V. Korotkov, Elizaveta I. Eletskaya, Nikolai V. Ravin and Liudmila M. Tsybalova

    Citation: Journal of Biomedical Science 2018 25:33

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  33. Content type: Research

    During metastasis, cancer cells require anokis resistant mechanism to survive until reach the distant secondary tissues. As anoikis sensitization may benefit for cancer therapy, this study demonstrated the pot...

    Authors: Arisara Prateep, Somruethai Sumkhemthong, Wiranpat Karnsomwan, Wanchai De-Eknamkul, Supakarn Chamni, Pithi Chanvorachote and Chatchai Chaotham

    Citation: Journal of Biomedical Science 2018 25:32

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  34. Content type: Review

    Nasopharyngeal carcinoma (NPC) is a head and neck cancer with poor clinical outcomes and insufficient treatments in Southeast Asian populations. Although concurrent chemoradiotherapy has improved recovery rate...

    Authors: Chang-Yu Chen, Yung-Song Lin, Chien-Ho Chen and Yin-Ju Chen

    Citation: Journal of Biomedical Science 2018 25:30

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  35. Content type: Research

    Tumor hypoxia-induced epithelial–mesenchymal transition (EMT) is critical in promoting cancer metastasis. We recently discovered a novel microtubule inhibitor, MPT0B098, that employs a novel antitumor mechanis...

    Authors: I-Ting Tsai, Ching-Chuan Kuo, Jing-Ping Liou and Jang-Yang Chang

    Citation: Journal of Biomedical Science 2018 25:28

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  36. Content type: Review

    Advances in Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated system (CRISPR/Cas9) has dramatically reshaped our ability to edit genomes. The scientific community is using CRISPR/Cas9...

    Authors: Sehrish Khan, Muhammad Shahid Mahmood, Sajjad ur Rahman, Hassan Zafar, Sultan Habibullah, Zulqarnain khan and Aftab Ahmad

    Citation: Journal of Biomedical Science 2018 25:29

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  37. Content type: Research

    β-aminoisobutyric acid (BAIBA) is produced in skeletal muscle during exercise and has beneficial effects on obesity-related metabolic disorders such as diabetes and non-alcoholic fatty liver disease. Thus, it ...

    Authors: Tae Woo Jung, Hyung Sub Park, Geum Hee Choi, Daehwan Kim and Taeseung Lee

    Citation: Journal of Biomedical Science 2018 25:27

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  38. Content type: Review

    Parkinson’s disease is described as resulting from dopaminergic cells progressive degeneration, specifically in the substantia nigra pars compacta that influence the voluntary movements control, decision makin...

    Authors: Francisco Magalhães, Kaline Rocha, Victor Marinho, Jéssica Ribeiro, Thomaz Oliveira, Carla Ayres, Thalys Bento, Francisca Leite, Daya Gupta, Victor Hugo Bastos, Bruna Velasques, Pedro Ribeiro, Marco Orsini and Silmar Teixeira

    Citation: Journal of Biomedical Science 2018 25:26

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  39. Content type: Research

    Adiponectin (ADN) is an adipokine derived from adipocytes. It binds to adiponectin receptor 1 and 2 (AdipoR1 and R2) to exert its function in regulating whole-body energy homeostasis and inflammatory responses...

    Authors: Yu-Ju Peng, Tang-Long Shen, Yu-Shan Chen, Harry John Mersmann, Bing-Hsien Liu and Shih-Torng Ding

    Citation: Journal of Biomedical Science 2018 25:24

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