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  1. Content type: Research

    Intracerebral hemorrhage (ICH) induces a complex sequence of apoptotic cascades that contribute to secondary neuronal damage. Tropomyosin-related kinase receptor B (TrkB) signaling plays a crucial role in prom...

    Authors: Chun-Hu Wu, Chien-Cheng Chen, Tai-Ho Hung, Yen-Chieh Chuang, Min Chao, Song-Kun Shyue and Szu-Fu Chen

    Citation: Journal of Biomedical Science 2019 26:53

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  2. Content type: Review

    Carbon utilization and metabolism are fundamental to every living organism for cellular growth. For intracellular human fungal pathogens such as Candida glabrata, an effective metabolic adaptation strategy is oft...

    Authors: Shu Yih Chew, Wallace Jeng Yang Chee and Leslie Thian Lung Than

    Citation: Journal of Biomedical Science 2019 26:52

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  3. Content type: Research

    Identifying bone anabolic agents is a superior strategy for the treatment of osteoporosis. Naturally, derived coumarin derivatives have shown osteoanabolic effect in vitro and in vivo. In this study, we invest...

    Authors: Basem M. Abdallah and Enas M. Ali

    Citation: Journal of Biomedical Science 2019 26:51

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  4. Content type: Retraction Note

    The Editor-in-Chief has retracted this article [1] due to significant overlap with previously published articles [2–5]. Both authors agree with this retraction.

    Authors: Sadhana M. Gupta and Jayanti Mania-Pramanik

    Citation: Journal of Biomedical Science 2019 26:50

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    The original article was published in Journal of Biomedical Science 2019 26:28

  5. Content type: Research

    Human enteroviruses contain over 100 serotypes. We have routinely conducted enterovirus surveillance in northern Taiwan; but about 10% of isolates could not be serotyped using traditional assays. Next-generati...

    Authors: Yeh-Sheng Chien, Shu-Ting Luo, Kuo-Chien Tsao, Yhu-Chering Huang, Wan-Yu Chung, Yu-Chieh Liao, Yi Tan, Suman R. Das and Min-Shi Lee

    Citation: Journal of Biomedical Science 2019 26:49

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  6. Content type: Review

    Oncolytic virotherapy has currently emerged as a promising approach upon which scientists have been able to induce tumor-specific cell death in a broad spectrum of malignancies. Paramyxoviruses represent intri...

    Authors: Mohsen Keshavarz, Farid Solaymani-Mohammadi, Seyed Mohammad Miri and Amir Ghaemi

    Citation: Journal of Biomedical Science 2019 26:48

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  7. Content type: Research

    Triggering receptor expressed on myeloid cells-1 (TREM-1) is highly expressed on macrophages in inflamed intestines and reportedly promotes inflammatory bowel disease (IBD) by augmenting pro-inflammatory respo...

    Authors: Fu-Chen Yang, Po-Yuan Chiu, Yun Chen, Tak W. Mak and Nien-Jung Chen

    Citation: Journal of Biomedical Science 2019 26:46

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  8. Content type: Research

    Our previous report suggested that centrosomal P4.1-associated protein (CPAP) is required for Hepatitis B virus (HBV) encoded non-structure protein X (HBx)-mediated nuclear factor kappa light chain enhancer of...

    Authors: Chia-Jui Yen, Shu-Ting Yang, Ruo-Yu Chen, Wenya Huang, Kazuaki Chayama, Ming-Hao Lee, Shiang-Jie Yang, Hong-Sheng Lai, Hsin-Yi Yen, Yu-Wei Hsiao, Ju-Ming Wang, Yih-Jyh Lin and Liang-Yi Hung

    Citation: Journal of Biomedical Science 2019 26:44

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  9. Content type: Research

    Stroke is the second most common cause of deaths worldwide. After an ischemic stroke, the proliferated reactive astrocytes in the peri-infarct areas play a beneficial role in neuronal survival. As such, astroc...

    Authors: Sujira Mukda, Ching-Yi Tsai, Steve Leu, Jenq-Lin Yang and Samuel H. H. Chan

    Citation: Journal of Biomedical Science 2019 26:43

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  10. Content type: Review

    Protein ubiquitination is an important mechanism for regulating the activity and levels of proteins under physiological conditions. Loss of regulation by protein ubiquitination leads to various diseases, such ...

    Authors: Ming-Jer Young, Kai-Cheng Hsu, Tony Eight Lin, Wen-Chang Chang and Jan-Jong Hung

    Citation: Journal of Biomedical Science 2019 26:42

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  11. Content type: Research

    Endoplasmic reticulum stress has a profound effect on cancer cell proliferation and survival, and also has the capacity to activate cells of the adaptive immune system. Multimodal treatment methods that utiliz...

    Authors: Sung Yong Lee, Jee Youn Oh, Tae Heung Kang, Hyun Seock Shin, Max A. Cheng, Emily Farmer, T.-C. Wu and Chien-Fu Hung

    Citation: Journal of Biomedical Science 2019 26:41

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  12. Content type: Research

    Oxidative stress is a major factor in retinal pigment epithelium (RPE) cells injury that contributes to age-related macular degeneration (AMD). NaIO3 is an oxidative toxic agent and its selective RPE cell dama...

    Authors: Chi-Ming Chan, Duen-Yi Huang, Ponarulselvam Sekar, Shu-Hao Hsu and Wan-Wan Lin

    Citation: Journal of Biomedical Science 2019 26:40

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  13. Content type: Review

    Sudden cardiac death (SCD) is a sudden, unexpected death that is caused by the loss of heart function. While SCD affects many patients suffering from coronary artery diseases (CAD) and heart failure (HF), a co...

    Authors: Junaida Osman, Shing Cheng Tan, Pey Yee Lee, Teck Yew Low and Rahman Jamal

    Citation: Journal of Biomedical Science 2019 26:39

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  14. Content type: Research

    The blood–spinal cord barrier (BSCB) is composed of a monolayer of endothelium linked with tight junctions and extracellular matrix (ECM)-rich basement membranes and is surrounded by astrocyte foot processes. ...

    Authors: Ting-Hein Lee, Sung-Tsang Hsieh and Hou-Yu Chiang

    Citation: Journal of Biomedical Science 2019 26:37

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  15. Content type: Research

    Vascular dementia is the second dementing illness after Alzheimer’s disease and caused by reduced blood flow to the brain, and affects cognitive abilities. Our previous study found that auricular electrical st...

    Authors: Tai-Hsiang Huang, Yi-Wen Lin, Chun-Ping Huang, Jing-Ming Chen and Ching-Liang Hsieh

    Citation: Journal of Biomedical Science 2019 26:36

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  16. Content type: Review

    Extracellular vesicle (EV)-mediated intercellular communication acts as a critical culprit in cancer development. The selective packaging of oncogenic molecules renders tumor-derived EVs capable of altering th...

    Authors: Yu-Ling Tai, Pei-Yu Chu, Bao-Hong Lee, Ko-Chien Chen, Chia-Yu Yang, Wen-Hung Kuo and Tang-Long Shen

    Citation: Journal of Biomedical Science 2019 26:35

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  17. Content type: Review

    Nicotinamide adenine dinucleotide (NAD) is an important coenzyme that participates in various energy metabolism pathways, including glycolysis, β-oxidation, and oxidative phosphorylation. Besides, it is a requ...

    Authors: Keisuke Okabe, Keisuke Yaku, Kazuyuki Tobe and Takashi Nakagawa

    Citation: Journal of Biomedical Science 2019 26:34

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  18. Content type: Review

    Alzheimer’s disease (AD) is the most common type of dementia and typically manifests through a progressive loss of episodic memory and cognitive function, subsequently causing language and visuospatial skills ...

    Authors: Marcos Vinícius Ferreira Silva, Cristina de Mello Gomide Loures, Luan Carlos Vieira Alves, Leonardo Cruz de Souza, Karina Braga Gomes Borges and Maria das Graças Carvalho

    Citation: Journal of Biomedical Science 2019 26:33

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  19. Content type: Research

    Our previous studies have demonstrated that Ca2+ desensitizing catechin could correct diastolic dysfunction in experimental animals with restrictive cardiomyopathy. In this study, it is aimed to assess the effect...

    Authors: Junjun Quan, Zhongli Jia, Tiewei Lv, Lei Zhang, Lingjuan Liu, Bo Pan, Jing Zhu, Ira J. Gelb, Xupei Huang and Jie Tian

    Citation: Journal of Biomedical Science 2019 26:32

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  20. Content type: Correction

    In the original publication of this article [1], there are two errors in the article which the cDNA position of the pathogenic variant WNT1 p.Gly324Cys should be c.970G>T instead of c.1168G>T.

    Authors: Mehran Kausar, Saima Siddiqi, Muhammad Yaqoob, Sajid Mansoor, Outi Makitie, Asif Mir, Chiea Chuen Khor, Jia Nee Foo and Mariam Anees

    Citation: Journal of Biomedical Science 2019 26:31

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    The original article was published in Journal of Biomedical Science 2018 25:82

  21. Content type: Research

    Promyelocytic leukemia zinc finger (Plzf), a transcriptional regulator involved in a lot of important biological processes during development, has been implied to maintain neural stem cells and inhibit their d...

    Authors: Hsin-Chuan Lin, Yung-Hao Ching, Chi-Chen Huang, Ping-Chieh Pao, Yi-Hua Lee, Wen-Chang Chang, Tzu-Jen Kao and Yi-Chao Lee

    Citation: Journal of Biomedical Science 2019 26:30

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  22. Content type: Review

    Cervical cancer is the fourth most frequent cancer in women worldwide and a major cause of mortality in developing countries. Persistent infection with high-risk human papillomavirus (HPV) is a necessary cause...

    Authors: Sadhana M. Gupta and Jayanti Mania-Pramanik

    Citation: Journal of Biomedical Science 2019 26:28

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    The Retraction Note to this article has been published in Journal of Biomedical Science 2019 26:50

  23. Content type: Research

    Promoting post-stroke neurogenesis has long been proposed to be a therapeutic strategy for the enhancement of functional recovery after cerebral ischemic stroke. Despite numerous approaches have been widely re...

    Authors: Joen-Rong Sheu, Cheng-Ying Hsieh, Thanasekaran Jayakumar, Guan-Yi Lin, Hsing-Ni Lee, Shin-Wei Huang and Chih-Hao Yang

    Citation: Journal of Biomedical Science 2019 26:27

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  24. Content type: Research

    Traumatic experience may lead to various psychological sequelae including the unforgettable trauma-associated memory as seen in posttraumatic stress disorder (PTSD), with a mechanism of impaired fear extinctio...

    Authors: Sheng-Chiang Wang, Chen-Cheng Lin, Nian-Sheng Tzeng, Che-Se Tung and Yia-Ping Liu

    Citation: Journal of Biomedical Science 2019 26:26

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  25. Content type: Review

    Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute k...

    Authors: Vladislav Volarevic, Bojana Djokovic, Marina Gazdic Jankovic, C. Randall Harrell, Crissy Fellabaum, Valentin Djonov and Nebojsa Arsenijevic

    Citation: Journal of Biomedical Science 2019 26:25

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  26. Content type: Review

    The liver is controlled by several metabolic hormones, including thyroid hormone, and characteristically displays high lysosomal activity as well as metabolic stress-triggered autophagy, which is stringently r...

    Authors: Hsiang-Cheng Chi, Chung-Ying Tsai, Ming-Ming Tsai, Chau-Ting Yeh and Kwang-Huei Lin

    Citation: Journal of Biomedical Science 2019 26:24

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  27. Content type: Research

    Helicobacter pylori bacteria colonize human gastric mucosa, cause chronic inflammation, peptic ulcers and gastric cancer. Colonization is mediated by H. pylori adhesins, which preferentially bind mucin 5 (MUC5AC)...

    Authors: Weronika Gonciarz, Maria Walencka, Anthony P. Moran, Krzysztof Hinc, Michał Obuchowski and Magdalena Chmiela

    Citation: Journal of Biomedical Science 2019 26:23

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  28. Content type: Research

    Psychological investigations and functional imaging technology have been used to describe neural correlations of different types of memory with various stimuli. Memory with limited storage capacity and a short...

    Authors: Jingxin Nie, Zengqiang Zhang, Bin Wang, Hong Li, Jianghua Xu, Sheng Wu, Chunhua Zhu, Xin Yang, Bin Liu, Yongming Wu, Sheng Tan, Zhibo Wen, Jinlong Zheng, Siyun Shu and Lin Ma

    Citation: Journal of Biomedical Science 2019 26:22

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  29. Content type: Research

    The most important limitations of morphine in pain therapy are its tolerance and dependence. In this study, we evaluated the protective effect of glucosamine against morphine-induced tolerance and dependence i...

    Authors: Faezeh Basiri, Abolfazl Rad, Davood Mahdian, Mehdi Molavi and Bahareh Amin

    Citation: Journal of Biomedical Science 2019 26:21

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  30. Content type: Research

    Prognosis of esophageal squamous cell carcinoma (ESCC) patients is poor and the concurrent chemoradiation therapy (CCRT) provided to ESCC patients often failed due to resistance. Therefore, development of biom...

    Authors: I-Ying Kuo, Yu-Lin Huang, Chien-Yu Lin, Chien-Hsun Lin, Wei-Lun Chang, Wu-Wei Lai and Yi-Ching Wang

    Citation: Journal of Biomedical Science 2019 26:20

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  31. Content type: Review

    The intestinal mucosa is a site of multiple stressors and forms the barrier between the internal and external environment. In the intestine, a complex interplay between the microbiota, epithelial barrier and t...

    Authors: Sabah Haq, Jensine Grondin, Suhrid Banskota and Waliul I. Khan

    Citation: Journal of Biomedical Science 2019 26:19

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  32. Content type: Research

    Head and neck squamous carcinoma (HNSCC) is one of the most invasive types of cancer with high mortality. A previous study has indicated that low levels of let-7d and miR-205 in HNSCC patients are correlated w...

    Authors: Tomasz Kolenda, Kacper Guglas, Anna Teresiak, Renata Bliźniak and Katarzyna Lamperska

    Citation: Journal of Biomedical Science 2019 26:17

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  33. Content type: Research

    Shiga toxin 2 from enterohemorrhagic Escherichia coli is the etiologic agent of bloody diarrhea, hemolytic uremic syndrome and derived encephalopathies that may result to death in patients. Being a Gram negative ...

    Authors: Clara Berdasco, Alipio Pinto, Valeria Calabró, David Arenas, Adriana Cangelosi, Patricia Geoghegan, Pablo Evelson and Jorge Goldstein

    Citation: Journal of Biomedical Science 2019 26:16

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  34. Content type: Review

    Among the various types of dementia, Alzheimer’s disease (AD) is the most prevalent and is clinically defined as the appearance of progressive deficits in cognition and memory. Considering that AD is a central...

    Authors: Fernanda Majolo, Daniel Rodrigo Marinowic, Denise Cantarelli Machado and Jaderson Costa Da Costa

    Citation: Journal of Biomedical Science 2019 26:15

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  35. Content type: Research

    Nasopharyngeal carcinoma (NPC), a highly invasive tumor, exhibits a distinctive racial and geographic distribution. As options of agents for effective combination chemoradiotherapy for advanced NPC are limited...

    Authors: Zhihai Wang, Wenqi Zuo, Quan Zeng, Yi Qian, Yanshi Li, Chuan Liu, Jue Wang, Shixun Zhong, Youquan Bu and Guohua Hu

    Citation: Journal of Biomedical Science 2019 26:14

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  36. Content type: Research

    Dysregulated long noncoding RNAs (lncRNAs) are involved in the development of tumor. Aberrant methylation is one of the most frequent epigenetic alterations that regulate the expression of genes. The aim of th...

    Authors: Wenxia Meng, Weina Cui, Lei Zhao, Weiwei Chi, Huan Cao and Baoshan Wang

    Citation: Journal of Biomedical Science 2019 26:13

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  37. Content type: Research

    Osteoclasts (OCs) are motile multinucleated cells derived from differentiation and fusion of hematopoietic progenitors of the monocyte-macrophage lineage that undergo a multistep process called osteoclastogene...

    Authors: Chu-Lung Chan, Jiann-Yeu Chen, Ming-Chih Shih, Chih-Lueh Albert Wang and Ying-Ming Liou

    Citation: Journal of Biomedical Science 2019 26:12

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  38. Content type: Review

    Stress is deeply rooted in the modern society due to limited resources and large competition to achieve the desired goal. Women are more frequently exposed to several stressors during their reproductive age th...

    Authors: Govind R. Chaudhary, Pramod K. Yadav, Anil K. Yadav, Meenakshi Tiwari, Anumegha Gupta, Alka Sharma, Ashutosh N. Pandey, Ajai K. Pandey and Shail K. Chaube

    Citation: Journal of Biomedical Science 2019 26:11

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  39. Content type: Research

    Toxoplasma gondii is a protozoan parasite that causes congenital toxoplasmosis by transplacental transmission. Parasite strains are genetically diverse and disease severity is related to the genotype. In Uberlând...

    Authors: Priscila Silva Franco, Paula Suellen Guimarães Gois, Thádia Evelyn de Araújo, Rafaela José da Silva, Bellisa de Freitas Barbosa, Angelica de Oliveira Gomes, Francesca Ietta, Lara Affonso dos Santos, Maria Célia dos Santos, José Roberto Mineo and Eloisa Amália Vieira Ferro

    Citation: Journal of Biomedical Science 2019 26:10

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  40. Content type: Review

    Cancer metastasis is the major cause of mortality in cancer cases and is responsible for cancer deaths. It is known that cancer cells communicate with surrounding microenvironmental cells, such as fibroblast c...

    Authors: Akiko Kogure, Nobuyoshi Kosaka and Takahiro Ochiya

    Citation: Journal of Biomedical Science 2019 26:7

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  41. Content type: Research

    Pulmonary hypertension (PH) is a progressive disease leading to death ultimately. Our recently published data demonstrated that inhibiting dipeptidyl peptidase IV (DPP-4) alleviated pulmonary vascular remodeli...

    Authors: Jingjing Wang, Min Yu, Jian Xu, Yusheng Cheng, Xiang Li, Guihong Wei, Hong Wang, Hui Kong and Weiping Xie

    Citation: Journal of Biomedical Science 2019 26:6

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  42. Content type: Review

    Rosmarinus officinalis L. (rosemary) is a medicinal plant native to the Mediterranean region and cultivated around the world. Besides the therapeutic purpose, it is commonly used as a condiment and food preservat...

    Authors: Jonatas Rafael de Oliveira, Samira Esteves Afonso Camargo and Luciane Dias de Oliveira

    Citation: Journal of Biomedical Science 2019 26:5

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  43. Content type: Research

    H. pylori CagL-Y58/E59 increase gastric cancer risk by stronger binding with integrin to faciliate type IV secretory system (T4SS). H. pylori can secrete high temperature requirement A (HtrA) to mediate E-Cadheri...

    Authors: Yi-Chun Yeh, Hsin-Yu Kuo, Wei-Lun Chang, Hsiao-Bai Yang, Cheng-Chan Lu, Hsiu-Chi Cheng, Ming-Shiang Wu and Bor-Shyang Sheu

    Citation: Journal of Biomedical Science 2019 26:4

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