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  1. Content type: Review

    Obesity is one of the most invaliding and preventable diseases in the United States. Growing evidence suggests that there are sex differences in obesity in human and experimental animals. However, the specific...

    Authors: Sarah Jayne Fitzgerald, Amol Vijay Janorkar, Allison Barnes and Rodrigo Oscar Maranon

    Citation: Journal of Biomedical Science 2018 25:89

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  2. Content type: Research

    Cytokines play an important role in controlling the homeostasis of the immune system and infection with Human Immunodeficiency virus (HIV) leads to deregulated production of both pro- and anti-inflammatory cyt...

    Authors: Faustina Nkechi Osuji, Charles Chinedu Onyenekwe, Joseph Ebere Ahaneku and Nkiruka Rose Ukibe

    Citation: Journal of Biomedical Science 2018 25:88

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  3. Content type: Review

    Mitochondria autophagy, termed as mitophagy, is a mechanism of specific autophagic elimination of mitochondria. Mitophagy controls the quality and the number of mitochondria, eliminating dysfunctional or exces...

    Authors: Ruiqiao Guan, Wei Zou, Xiaohong Dai, Xueping Yu, Hao Liu, Qiuxin Chen and Wei Teng

    Citation: Journal of Biomedical Science 2018 25:87

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  4. Content type: Review

    Sensing tissue acidosis is an important function of the somatosensory nervous system to response to noxious stimuli.

    Authors: Jiann-Her Lin, Chih-Hsien Hung, Der-Sheng Han, Shih-Ting Chen, Cheng-Han Lee, Wei-Zen Sun and Chih-Cheng Chen

    Citation: Journal of Biomedical Science 2018 25:85

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  5. Content type: Research

    Osteogenesis imperfecta (OI) is a clinically and genetically heterogeneous disease with skeletal fragility and variable extra-skeletal manifestations. To date several point mutations in 18 different genes causing...

    Authors: Mehran Kausar, Saima Siddiqi, Muhammad Yaqoob, Sajid Mansoor, Outi Makitie, Asif Mir, Chiea Chuen Khor, Jia Nee Foo and Mariam Anees

    Citation: Journal of Biomedical Science 2018 25:82

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  6. Content type: Research

    Metformin is the most commonly used first-line medicine for type II diabetes mellitus. Acting via AMP-activated protein kinase, it has been used for more than 60 years and has an outstanding safety record. Met...

    Authors: Shu-Man Hsieh Li, Shu-Ting Liu, Yung-Lung Chang, Ching-Liang Ho and Shih-Ming Huang

    Citation: Journal of Biomedical Science 2018 25:81

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  7. Content type: Research

    TNS2 is a focal adhesions protein and a binding partner for many proteins, including the receptor tyrosine kinase Axl. Although TNS2 can bind with Axl, the details of their interactions have not been elucidate...

    Authors: Li-Chun Cheng, Yen-Lin Chen, An-Ning Cheng, Alan Yueh-Luen Lee, Chun-Yu Cho, Jhy-Shrian Huang and Shuang-En Chuang

    Citation: Journal of Biomedical Science 2018 25:80

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  8. Content type: Review

    Inflammatory bowel disease (IBD) is a multifactorial disease which arises as a result of the interaction of genetic, environmental, barrier and microbial factors leading to chronic inflammation in the intestin...

    Authors: Linda Chia-Hui Yu

    Citation: Journal of Biomedical Science 2018 25:79

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  9. Content type: Review

    Helicobacter pylori - (H. pylori) play a role in the pathogenesis of gastritis, gastric and duodenal ulcers as well as gastric cancer. A possible involvement of outer membrane vesicles (OMVs) produced by H. pylor...

    Authors: Magdalena Chmiela, Natalia Walczak and Karolina Rudnicka

    Citation: Journal of Biomedical Science 2018 25:78

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  10. Content type: Research

    The brain predominantly expressed RING finger protein, Znf179, is known to be important for embryonic neuronal differentiation during brain development. Downregulation of Znf179 has been observed in motor neur...

    Authors: Yi-Chao Lee, Wan-Chen Huang, Jiann-Her Lin, Tzu-Jen Kao, Hui-Ching Lin, Kuen-Haur Lee, Hsin-Chuan Lin, Che-Kun James Shen, Wen-Chang Chang and Chi-Chen Huang

    Citation: Journal of Biomedical Science 2018 25:76

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  11. Content type: Review

    Dengue virus, the causative agent of dengue disease which may have hemorrhagic complications, poses a global health threat. Among the numerous target cells for dengue virus in humans are monocytes, macrophages...

    Authors: Shu-Wen Wan, Betty A. Wu-Hsieh, Yee-Shin Lin, Wen-Yu Chen, Yan Huang and Robert Anderson

    Citation: Journal of Biomedical Science 2018 25:77

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  12. Content type: Review

    Jaundice is a common symptom of inherited or acquired liver diseases or a manifestation of diseases involving red blood cell metabolism. Recent progress has elucidated the molecular mechanisms of bile metaboli...

    Authors: Huey-Ling Chen, Shang-Hsin Wu, Shu-Hao Hsu, Bang-Yu Liou, Hui-Ling Chen and Mei-Hwei Chang

    Citation: Journal of Biomedical Science 2018 25:75

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  13. Content type: Research

    Alternative polyadenylation (APA) is a widespread phenomenon in the posttranscriptional regulation of gene expression that generates mRNAs with alternative 3′-untranslated regions (3’UTRs). APA contributes to ...

    Authors: Ya-Fei Xu, Ying-Qing Li, Na Liu, Qing-Mei He, Xin-Ran Tang, Xin Wen, Xiao-Jing Yang, Ying Sun, Jun Ma and Ling-Long Tang

    Citation: Journal of Biomedical Science 2018 25:74

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  14. Content type: Review

    Visceral pain is a complex and heterogeneous disorder, which can range from the mild discomfort of indigestion to the agonizing pain of renal colic. Regulation of visceral pain involves the spinal cord as well...

    Authors: Matteo M Pusceddu and Melanie G Gareau

    Citation: Journal of Biomedical Science 2018 25:73

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  15. Content type: Research

    Neurofibromatosis type 1 (NF1) is a dominantly inherited tumor predisposition syndrome that targets the peripheral nervous system. It is caused by mutations of the NF1 gene which serve as a negative regulator of ...

    Authors: Yah-Huei Wu-Chou, Tzu-Chao Hung, Yin-Ting Lin, Hsing-Wen Cheng, Ju-Li Lin, Chih-Hung Lin, Chung-Chih Yu, Kuo-Ting Chen, Tu-Hsueh Yeh and Yu-Ray Chen

    Citation: Journal of Biomedical Science 2018 25:72

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  16. Content type: Research

    Human papillomavirus (HPV) is the most common sexually transmitted virus in women worldwide. The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelia...

    Authors: Nádia Calvo Martins Okuyama, Fernando Cezar-dos-Santos, Érica Romão Pereira, Kleber Paiva Trugilo, Guilherme Cesar Martelossi Cebinelli, Michelle Mota Sena, Ana Paula Lombardi Pereira, Adriano Martin Felis Aranome, Luis Fernando Lasaro Mangieri, Rodolfo Sanches Ferreira, Maria Angelica Ehara Watanabe and Karen Brajão de Oliveira

    Citation: Journal of Biomedical Science 2018 25:69

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  17. Content type: Review

    Ubiquitination modulates a large repertoire of cellular functions and thus, dysregulation of the ubiquitin system results in multiple human diseases, including cancer. Ubiquitination requires an E3 ligase, whi...

    Authors: Shih-Han Kao, Han-Tsang Wu and Kou-Juey Wu

    Citation: Journal of Biomedical Science 2018 25:67

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  18. Content type: Review

    Helicobacter pylori infection is the principal cause of peptic ulcer disease, gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue lymphoma. Recent studies have shown that it may interfere with ma...

    Authors: Feng-Woei Tsay and Ping-I Hsu

    Citation: Journal of Biomedical Science 2018 25:65

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  19. Content type: Review

    Esophageal squamous cell carcinoma (ESCC) is the predominant subtype of esophageal cancer worldwide and highly prevalent in less developed regions. Management of ESCC is challenging and involves multimodal tre...

    Authors: Nikki P. Lee, Chung Man Chan, Lai Nar Tung, Hector K. Wang and Simon Law

    Citation: Journal of Biomedical Science 2018 25:66

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  20. Content type: Research

    B cells play an essential role during dengue viral infection. While a major expansion of antibody secreting cells (ASCs) was observed, the importance of these increased frequencies of ASCs remains unclear. The...

    Authors: Kovit Pattanapanyasat, Ladawan Khowawisetsut, Ampaiwan Chuansumrit, Kulkanya Chokephaibulkit, Kanchana Tangnararatchakit, Nopporn Apiwattanakul, Chonnamet Techasaensiri, Premrutai Thitilertdecha, Tipaporn Sae-Ung and Nattawat Onlamoon

    Citation: Journal of Biomedical Science 2018 25:64

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  21. Content type: Research

    Glioblastoma multiforme (GBM) is one of the lethal malignant tumors of the central nervous system. Despite advances made in understanding this complex disease, little has been achieved in improving clinical ef...

    Authors: Ira Sharma, Avninder Singh, Fouzia Siraj and Sunita Saxena

    Citation: Journal of Biomedical Science 2018 25:62

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  22. Content type: Review

    Studies at the molecular level aim to integrate genetic and neurobiological data to provide an increasingly detailed understanding of phenotypes related to the ability in time perception.

    Authors: Victor Marinho, Thomaz Oliveira, Juliete Bandeira, Giovanny R. Pinto, Anderson Gomes, Valéria Lima, Francisco Magalhães, Kaline Rocha, Carla Ayres, Valécia Carvalho, Bruna Velasques, Pedro Ribeiro, Marco Orsini, Victor Hugo Bastos, Daya Gupta and Silmar Teixeira

    Citation: Journal of Biomedical Science 2018 25:61

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  23. Content type: Research

    Cancer stem cells are capable of undergoing cell division after surviving cancer therapies, leading to tumor progression and recurrence. Inhibitory agents against cancer stem cells may be therapeutically used ...

    Authors: Chun-Chia Cheng, Po-Nien Liao, Ai-Sheng Ho, Ken-Hong Lim, Jungshan Chang, Ying-Wen Su, Caleb Gon-Shen Chen, Ya-Wen Chiang, Bi-Ling Yang, Huan-Chau Lin, Yu-Cheng Chang, Chun-Chao Chang and Yi-Fang Chang

    Citation: Journal of Biomedical Science 2018 25:60

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  24. Content type: Research

    Hepatitis B virus (HBV) infection is a common disease worldwide and is known to cause liver disease. C-type lectin 18 (CLEC18) is a novel secretory lectin highly expressed in human hepatocytes. Because the liv...

    Authors: Tsung-Yu Tsai, Cheng-Yuan Peng, Hwai-I Yang, Ya-Lang Huang, Mi-Hua Tao, Shin-Sheng Yuan, Hsueh-Chou Lai and Shie-Liang Hsieh

    Citation: Journal of Biomedical Science 2018 25:59

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  25. Content type: Research

    Induced pluripotency in cancer cells by ectopic expression of pluripotency-regulating factors may be used for disease modeling of cancers. MicroRNAs (miRNAs) are negative regulators of gene expression that pla...

    Authors: Michele Sook Yuin Hiew, Han Ping Cheng, Chiu-Jung Huang, Kowit Yu Chong, Soon Keng Cheong, Kong Bung Choo and Tunku Kamarul

    Citation: Journal of Biomedical Science 2018 25:57

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  26. Content type: Research

    Sepsis is a life-threatening disease mediated by profound disturbances in systemic inflammatory response to infection. IL-33 is multifunctional regulator of numerous aspects of innate and adaptive immune respo...

    Authors: Zivan M. Babic, Filip Z. Zunic, Jelena M. Pantic, Gordana D. Radosavljevic, Ivan P. Jovanovic, Nebojsa N. Arsenijevic and Miodrag L. Lukic

    Citation: Journal of Biomedical Science 2018 25:56

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  27. Content type: Research

    The nuclear translocation of epidermal growth factor receptor (EGFR) has been considered to play a role in carcinogenesis. However, the relevance of differentially located EGFR proteins in lung cancer remains ...

    Authors: Jinn-Li Wang, Chia-Lang Fang, Yu-Tien Tzeng, Han-Lin Hsu, Sey-En Lin, Ming-Chih Yu, Kuan-Jen Bai, Liang-Shun Wang and Hsingjin Eugene Liu

    Citation: Journal of Biomedical Science 2018 25:53

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  28. Content type: Review

    Parkinson’s disease (PD) is the most common movement disorder and manifests as resting tremor, rigidity, bradykinesia, and postural instability. Pathologically, PD is characterized by selective loss of dopamin...

    Authors: Meng-Ling Chen and Ruey-Meei Wu

    Citation: Journal of Biomedical Science 2018 25:52

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  29. Content type: Review

    Next-generation sequencing (NGS) is a powerful and high-throughput method for the detection of viral mutations. This article provides a brief overview about optimization of NGS analysis for hepatocellular carc...

    Authors: I-Chin Wu, Wen-Chun Liu and Ting-Tsung Chang

    Citation: Journal of Biomedical Science 2018 25:51

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  30. Content type: Research

    Kisspeptin is involved in female reproduction. This study was designed to i- estimate kisspeptin levels in women with polycystic ovary syndrome (PCOS), in comparison with controls, ii- study the correlations b...

    Authors: Fadwa S. Albalawi, Maha H. Daghestani, Mazin H. Daghestani, Abdelmoneim Eldali and Arjumand S. Warsy

    Citation: Journal of Biomedical Science 2018 25:50

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  31. Content type: Review

    Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors. Best known for its role in transducing signals link...

    Authors: Robert F. Hillary and Una FitzGerald

    Citation: Journal of Biomedical Science 2018 25:48

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  32. Content type: Research

    Few studies have examined the relationship between the amounts of heavy metal and stroke incidence. The aim of this study was to explore the relationship between levels of heavy metals, including Pb, Hg, As, a...

    Authors: Ching-Huang Lin, Yi-Ting Hsu, Cheng-Chung Yen, Hsin-Hung Chen, Ching-Jiunn Tseng, Yuk-Keung Lo and Julie Y. H. Chan

    Citation: Journal of Biomedical Science 2018 25:49

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  33. Content type: Research

    Middle East respiratory syndrome coronavirus (MERS-CoV) consists of a positive-sense, single-stranded RNA genome and four structural proteins: the spike, envelope, membrane, and nucleocapsid protein. The assem...

    Authors: Wei-Chen Hsin, Chan-Hua Chang, Chi-You Chang, Wei-Hao Peng, Chung-Liang Chien, Ming-Fu Chang and Shin C. Chang

    Citation: Journal of Biomedical Science 2018 25:47

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  34. Content type: Research

    Lead (Pb2+) is an environmental neurotoxicant that disrupts neurodevelopment, communication, and organization through competition with Ca2+ signaling. How perinatal Pb2+ exposure affects Ca2+-related gene regulat...

    Authors: Lorenz S. Neuwirth, Greg R. Phillips and Abdeslem El Idrissi

    Citation: Journal of Biomedical Science 2018 25:45

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  35. Content type: Review

    The Myristoylated Alanine-Rich C-kinase Substrate (MARCKS) and MARCKS-like protein 1 (MARCKSL1) have a wide range of functions, ranging from roles in embryonic development to adult brain plasticity and the inf...

    Authors: Mohamed El Amri, Una Fitzgerald and Gerhard Schlosser

    Citation: Journal of Biomedical Science 2018 25:43

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  36. Content type: Research

    Transmembrane Ca2+ influx is critical for molecular rhythmicity, metabolic activity, and neuropeptide release in the central clock of the suprachiasmatic nucleus (SCN). We previously reported that both the Na+/Ca

    Authors: Pi-Cheng Cheng, Yi-Chi Wang, Ya-Shuan Chen, Ruo-Ciao Cheng, Jyh-Jeen Yang and Rong-Chi Huang

    Citation: Journal of Biomedical Science 2018 25:44

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  37. Content type: Research

    Fibroblast growth factor (FGF)-2 plays a crucial role in the pathophysiology of cardiovascular diseases (CVDs). FGF-2 was reported to induce cardiac hypertrophy through activation of FGF receptor 1 (FGFR1). Mu...

    Authors: Ting-Wei Lee, Ting-I Lee, Yung-Kuo Lin, Yu-Hsun Kao and Yi-Jen Chen

    Citation: Journal of Biomedical Science 2018 25:42

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  38. Content type: Research

    Cholinergic hypothesis of Alzheimer’s disease (AD) is based on the findings that a reduced and/or perturbed cholinergic activity in the central nervous system correlates with cognitive decline in patients with...

    Authors: Alice Hálová, Jana Janoutová, Laura Ewerlingová, Vladimír Janout, Ondřej Bonczek, Tomáš Zeman, Tereza Gerguri, Vladimir J. Balcar and Omar Šerý

    Citation: Journal of Biomedical Science 2018 25:41

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  39. Content type: Research

    Second generation antipsychotics (SGAs) induce glucometabolic side-effects, such as hyperglycemia and insulin resistance, which pose a therapeutic challenge for mental illness. Sphingolipids play a role in gly...

    Authors: Katrina Weston-Green, Ilijana Babic, Michael de Santis, Bo Pan, Magdalene K. Montgomery, Todd Mitchell, Xu-Feng Huang and Jessica Nealon

    Citation: Journal of Biomedical Science 2018 25:40

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