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  1. Content type: Research

    Whether hepatic progenitor cells (HPCs)/oval cells regenerate liver mass upon chronic liver injury is controversial in mice and has not been conclusively proven in humans and rats. In this study, we examined w...

    Authors: Chin-Sung Chien, Ya-Hui Chen, Hui-Ling Chen, Chiu-Ping Wang, Shang-Hsin Wu, Shu-Li Ho, Wen-Cheng Huang, Chun-Hsien Yu and Mei-Hwei Chang

    Citation: Journal of Biomedical Science 2018 25:39

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  2. Content type: Review

    Millions of people around the world suffer from bone disorders, likes osteoporosis, rheumatoid arthritis (RA), and cancer-induced osteolysis. In general, the bone remodeling balance is determined by osteoclast...

    Authors: Hsiao-Hsuan Wang, Yu-Hsiang Hsu and Ming-Shi Chang

    Citation: Journal of Biomedical Science 2018 25:38

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  3. Content type: Review

    Mammalian ovary contains millions of germ cells during embryonic life but only few of them are culminated into oocytes that achieve meiotic competency just prior to ovulation. The majority of germ cells are de...

    Authors: Pramod K. Yadav, Meenakshi Tiwari, Anumegha Gupta, Alka Sharma, Shilpa Prasad, Ashutosh N. Pandey and Shail K. Chaube

    Citation: Journal of Biomedical Science 2018 25:36

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  4. Content type: Review

    The pathogenesis of systemic autoimmune diseases such as systemic lupus erythematosus (SLE) is based on the loss of self-tolerance against ubiquitous autoantigens involving all mechanisms of adaptive immunity....

    Authors: Satish Kumar Devarapu and Hans-Joachim Anders

    Citation: Journal of Biomedical Science 2018 25:35

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  5. Content type: Research

    SP110, an interferon-induced nuclear protein, belongs to the SP100/SP140 protein family. Very recently, we showed that SP110b, an SP110 isoform, controls host innate immunity to Mycobacterium tuberculosis infecti...

    Authors: Jia-Shiun Leu, So-Yi Chang, Chia-Yu Mu, Mei-Ling Chen and Bo-Shiun Yan

    Citation: Journal of Biomedical Science 2018 25:34

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  6. Content type: Research

    Current influenza vaccines are mainly strain-specific and have limited efficacy in preventing new, potentially pandemic, influenza strains. Efficient control of influenza A infection can potentially be achieve...

    Authors: Liudmila A. Stepanova, Eugenia S. Mardanova, Marina A. Shuklina, Elena A. Blokhina, Roman Y. Kotlyarov, Marina V. Potapchuk, Anna A. Kovaleva, Inna G. Vidyaeva, Alexandr V. Korotkov, Elizaveta I. Eletskaya, Nikolai V. Ravin and Liudmila M. Tsybalova

    Citation: Journal of Biomedical Science 2018 25:33

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  7. Content type: Research

    During metastasis, cancer cells require anokis resistant mechanism to survive until reach the distant secondary tissues. As anoikis sensitization may benefit for cancer therapy, this study demonstrated the pot...

    Authors: Arisara Prateep, Somruethai Sumkhemthong, Wiranpat Karnsomwan, Wanchai De-Eknamkul, Supakarn Chamni, Pithi Chanvorachote and Chatchai Chaotham

    Citation: Journal of Biomedical Science 2018 25:32

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  8. Content type: Review

    Nasopharyngeal carcinoma (NPC) is a head and neck cancer with poor clinical outcomes and insufficient treatments in Southeast Asian populations. Although concurrent chemoradiotherapy has improved recovery rate...

    Authors: Chang-Yu Chen, Yung-Song Lin, Chien-Ho Chen and Yin-Ju Chen

    Citation: Journal of Biomedical Science 2018 25:30

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  9. Content type: Research

    Tumor hypoxia-induced epithelial–mesenchymal transition (EMT) is critical in promoting cancer metastasis. We recently discovered a novel microtubule inhibitor, MPT0B098, that employs a novel antitumor mechanis...

    Authors: I-Ting Tsai, Ching-Chuan Kuo, Jing-Ping Liou and Jang-Yang Chang

    Citation: Journal of Biomedical Science 2018 25:28

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  10. Content type: Review

    Advances in Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated system (CRISPR/Cas9) has dramatically reshaped our ability to edit genomes. The scientific community is using CRISPR/Cas9...

    Authors: Sehrish Khan, Muhammad Shahid Mahmood, Sajjad ur Rahman, Hassan Zafar, Sultan Habibullah, Zulqarnain khan and Aftab Ahmad

    Citation: Journal of Biomedical Science 2018 25:29

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  11. Content type: Research

    β-aminoisobutyric acid (BAIBA) is produced in skeletal muscle during exercise and has beneficial effects on obesity-related metabolic disorders such as diabetes and non-alcoholic fatty liver disease. Thus, it ...

    Authors: Tae Woo Jung, Hyung Sub Park, Geum Hee Choi, Daehwan Kim and Taeseung Lee

    Citation: Journal of Biomedical Science 2018 25:27

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  12. Content type: Review

    Parkinson’s disease is described as resulting from dopaminergic cells progressive degeneration, specifically in the substantia nigra pars compacta that influence the voluntary movements control, decision makin...

    Authors: Francisco Magalhães, Kaline Rocha, Victor Marinho, Jéssica Ribeiro, Thomaz Oliveira, Carla Ayres, Thalys Bento, Francisca Leite, Daya Gupta, Victor Hugo Bastos, Bruna Velasques, Pedro Ribeiro, Marco Orsini and Silmar Teixeira

    Citation: Journal of Biomedical Science 2018 25:26

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  13. Content type: Research

    Adiponectin (ADN) is an adipokine derived from adipocytes. It binds to adiponectin receptor 1 and 2 (AdipoR1 and R2) to exert its function in regulating whole-body energy homeostasis and inflammatory responses...

    Authors: Yu-Ju Peng, Tang-Long Shen, Yu-Shan Chen, Harry John Mersmann, Bing-Hsien Liu and Shih-Torng Ding

    Citation: Journal of Biomedical Science 2018 25:24

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  14. Content type: Review

    Long non-coding RNAs (lncRNAs), which are a portion of non-protein-coding RNAs (ncRNAs), have manifested a paramount role in the pathophysiology of human diseases, particularly in pathogenesis and progression ...

    Authors: Cheng Sun, Lining Huang, Zhenglong Li, Kaiming Leng, Yi Xu, Xingming Jiang and Yunfu Cui

    Citation: Journal of Biomedical Science 2018 25:23

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  15. Content type: Review

    Limitless self-renewal is one of the hallmarks of cancer and is attained by telomere maintenance, essentially through telomerase (hTERT) activation. Transcriptional regulation of hTERT is believed to play a major...

    Authors: Ricardo Leão, Joana Dias Apolónio, Donghyun Lee, Arnaldo Figueiredo, Uri Tabori and Pedro Castelo-Branco

    Citation: Journal of Biomedical Science 2018 25:22

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  16. Content type: Review

    Pericytes are multipotent cells present in every vascularized tissue in the body. Despite the fact that they are well-known for more than a century, pericytes are still representing cells with intriguing prope...

    Authors: C. Randall Harrell, Bojana Simovic Markovic, Crissy Fellabaum, Aleksandar Arsenijevic, Valentin Djonov and Vladislav Volarevic

    Citation: Journal of Biomedical Science 2018 25:21

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  17. Content type: Review

    Cancer stem cells (CSCs) are subpopulations of cancer cells sharing similar characteristics as normal stem or progenitor cells such as self-renewal ability and multi-lineage differentiation to drive tumour gro...

    Authors: Ain Zubaidah Ayob and Thamil Selvee Ramasamy

    Citation: Journal of Biomedical Science 2018 25:20

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  18. Content type: Research

    In idiopathic pulmonary fibrosis, the interaction of CXCL12 and CXC receptor 4 (CXCR4) plays a critical role in lung fibrosis. Connective tissue growth factor (CTGF) overexpression underlies the development of...

    Authors: Chien-Huang Lin, Chung-Huang Shih, Yu-Chang Lin, You-Lan Yang and Bing-Chang Chen

    Citation: Journal of Biomedical Science 2018 25:19

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  19. Content type: Research

    LncRNA Gas5 is known to be a key control element during growth, differentiation and development in mammalian species. However, the role and function of Gas5 in growth plate chondrocytes has not been determined.

    Authors: Xiong Liu, Yuqi She, Hongrong Wu, Da Zhong and Jian Zhang

    Citation: Journal of Biomedical Science 2018 25:18

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  20. Content type: Research

    Breast cancer is the most common malignancy among women in the world. Development of novel tumor-specific radiopharmaceuticals for early breast tumor diagnosis is highly desirable. In this study we developed 99mT...

    Authors: Sajjad Ahmadpour, Zohreh Noaparast, Seyed Mohammad Abedi and Seyed Jalal Hosseinimehr

    Citation: Journal of Biomedical Science 2018 25:17

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  21. Content type: Research

    Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic cancer, with diverse molecular characteristics and clinical outcomes. This study aims to dissect the molecular heterogeneity of NPC, followed ...

    Authors: Lan Zhao, Alvin H. W. Fong, Na Liu and William C. S. Cho

    Citation: Journal of Biomedical Science 2018 25:16

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  22. Content type: Research

    Streptococcus pneumoniae or pneumococcus is a leading cause of morbidity and mortality worldwide, specifically in relation to community-acquired pneumonia. Due to the overuse of antibiotics, S. pneumoniae has dev...

    Authors: Hassan Mahmood Jindal, Babu Ramanathan, Cheng Foh Le, Ranganath Gudimella, Rozaimi Razali, Rishya Manikam and Shamala Devi Sekaran

    Citation: Journal of Biomedical Science 2018 25:15

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