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  1. The association of functionality and phenotype of follicular helper T cells (Tfh) with dengue virus (DENV) specific antibody responses and clinical disease severity has not been well studied.

    Authors: Ayesha Wijesinghe, Jayani Gamage, Hemantha Goonewardena, Laksiri Gomes, Deshni Jayathilaka, Dulharie T. Wijeratne, Ruklanthi de Alwis, Chandima Jeewandara, Ananda Wijewickrama, Graham S. Ogg and Gathsaurie Neelika Malavige

    Citation: Journal of Biomedical Science 2020 27:50

    Content type: Research

    Published on:

  2. With the advances in deep sequencing-based transcriptome profiling technology, it is now known that human genome is transcribed more pervasively than previously thought. Up to 90% of the human DNA is transcrib...

    Authors: Chih-Fan Yeh, Yu-Chen Eugene Chang, Cheng-Yuan Lu, Chin-Feng Hsuan, Wei-Tien Chang and Kai-Chien Yang

    Citation: Journal of Biomedical Science 2020 27:48

    Content type: Review

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  3. Influenza vaccine manufacturers traditionally use egg-derived candidate vaccine viruses (CVVs) to produce high-yield influenza viruses for seasonal or pandemic vaccines; however, these egg-derived CVVs need an...

    Authors: Tsai-Teng Tzeng, Po-Ling Chen, Tsai-Chuan Weng, Shin-Yi Tsai, Chia-Chun Lai, Hsin-I Chou, Pin-Wen Chen, Chia-Chun Lu, Ming-Tsan Liu, Wang-Chou Sung, Min-Shi Lee and Alan Yung-Chih Hu

    Citation: Journal of Biomedical Science 2020 27:47

    Content type: Research

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  4. Epigenetic silencing of retinoic acid (RA) signaling-related genes have been linked with the pathogenesis and clinical outcome in oral squamous cell carcinoma (OSCC) carcinogenesis. However, the precise mechan...

    Authors: Shine-Gwo Shiah, Jenn-Ren Hsiao, Hsiao-Ju Chang, Yuan-Ming Hsu, Guan-Hsun Wu, Hsuan-Yu Peng, Sung-Tau Chou, Ching-Chuan Kuo and Jang-Yang Chang

    Citation: Journal of Biomedical Science 2020 27:46

    Content type: Research

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  5. Human platelets (PLT) and PLT-extracellular vesicles (PEV) released upon thrombin activation express receptors that interact with tumour cells and, thus, can serve as a delivery platform of anti-cancer agents....

    Authors: Yu-Wen Wu, Cheng-Chain Huang, Chun Austin Changou, Long-Sheng Lu, Hadi Goubran and Thierry Burnouf

    Citation: Journal of Biomedical Science 2020 27:45

    Content type: Research

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  6. Stem cell activity is subject to non-cell-autonomous regulation from the local microenvironment, or niche. In adaption to varying physiological conditions and the ever-changing external environment, the stem c...

    Authors: Chih-Lung Chen, Wen-Yen Huang, Eddy Hsi Chun Wang, Kang-Yu Tai and Sung-Jan Lin

    Citation: Journal of Biomedical Science 2020 27:43

    Content type: Review

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  7. The underlying mechanism involved in ovarian cancer stemness and chemoresistance remains largely unknown. Here, we explored whether the regulation of c-Kit and plasma membrane prohibitin (PHB) affects ovarian ...

    Authors: Chia-Hsun Fang, Yi-Te Lin, Chi-Ming Liang and Shu-Mei Liang

    Citation: Journal of Biomedical Science 2020 27:42

    Content type: Research

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  8. Kaposi’s sarcoma-associated herpesvirus (KSHV), also designated human herpesvirus 8 (HHV-8), has been linked to Kaposi’s sarcoma, as well as to primary effusion lymphoma (PEL), and a subset of multicentric Cas...

    Authors: Mel Campbell and Yoshihiro Izumiya

    Citation: Journal of Biomedical Science 2020 27:41

    Content type: Review

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  9. The present study aimed to verify whether long noncoding RNA (lncRNA) MALAT1 is involved in brain tissue damage induced by ischemia-reperfusion injury, and to explore the mechanism by which MALAT1 regulates aquap...

    Authors: Hongwei Wang, Xiaoxiao Zheng, Jing Jin, Li Zheng, Ting Guan, Yangfan Huo, Shufen Xie, Ying Wu and Wei Chen

    Citation: Journal of Biomedical Science 2020 27:40

    Content type: Research

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  10. Aerobically-grown bacteria can be challenged by hydrogen peroxide stress from endogenous aerobic metabolism and exogenously generated reactive oxygen species. Catalase (Kat), alkyl hydroperoxidase (Ahp), and g...

    Authors: Li-Hua Li, Yung-Luen Shih, Jing-Yun Huang, Chao-Jung Wu, Yi-Wei Huang, Hsin-Hui Huang, Yu-Chieh Tsai and Tsuey-Ching Yang

    Citation: Journal of Biomedical Science 2020 27:37

    Content type: Research

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  11. Among gynecological cancers, ovarian carcinoma has the highest mortality rate, and chemoresistance is highly prevalent in this cancer. Therefore, novel strategies are required to improve its poor prognosis. Fo...

    Authors: Ho-Kai Huang, Yi-Hsin Lin, Heng-Ai Chang, Yi-Shyun Lai, Ying-Chi Chen, Soon-Cen Huang, Cheng-Yang Chou and Wen-Tai Chiu

    Citation: Journal of Biomedical Science 2020 27:36

    Content type: Research

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  12. Spinal cord injury (SCI) is a highly debilitating pathology without curative treatment. One of the most promising disease modifying strategies consists in the implantation of stem cells to reduce inflammation ...

    Authors: Lorenzo Romero-Ramírez, Siyu Wu, Johannes de Munter, Erik Ch. Wolters, Boris W. Kramer and Jörg Mey

    Citation: Journal of Biomedical Science 2020 27:35

    Content type: Research

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  13. In the past years evidence has been growing about the interconnection of chronic kidney disease and acute kidney injury. The underlying pathophysiological mechanisms remain unclear. We hypothesized, that a thr...

    Authors: Alexander Holderied, Franziska Kraft, Julian Aurelio Marschner, Marc Weidenbusch and Hans-Joachim Anders

    Citation: Journal of Biomedical Science 2020 27:34

    Content type: Research

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  14. Vaccination is the most effective measure at preventing influenza virus infections. However, current seasonal influenza vaccines are only protective against closely matched circulating strains. Even with exten...

    Authors: Juine-Ruey Chen, Yo-Min Liu, Yung-Chieh Tseng and Che Ma

    Citation: Journal of Biomedical Science 2020 27:33

    Content type: Review

    Published on:

  15. Fallopian tube epithelial cells (FTEC) were thought to be the origin of high-grade serous ovarian carcinoma (HGSOC). Knowledge of the stemness or initiating characteristics of FTEC is insufficient. Previously,...

    Authors: Yu-Hsun Chang, Tang-Yuan Chu and Dah-Ching Ding

    Citation: Journal of Biomedical Science 2020 27:32

    Content type: Research

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  16. X-linked inhibitor of apoptosis protein (XIAP), survivin, and BRUCE are members of the inhibitor-of-apoptosis protein (IAP) family known for their inhibitory effects on caspase activity and dysregulation of th...

    Authors: Chun Hei Antonio Cheung, Yung-Chieh Chang, Tzu-Yu Lin, Siao Muk Cheng and Euphemia Leung

    Citation: Journal of Biomedical Science 2020 27:31

    Content type: Review

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  17. The main strategy against nasopharyngeal carcinoma (NPC) is radiotherapy. However, radioresistance mediated recurrence is a leading clinical bottleneck in NPC. Revealing the mechanism of NPC radioresistance wi...

    Authors: Panpan Zhang, Xiaomin Li, Qiuping He, Lulu Zhang, Keqing Song, Xiaojing Yang, Qingmei He, Yaqin Wang, Xiaohong Hong, Jun Ma and Na Liu

    Citation: Journal of Biomedical Science 2020 27:30

    Content type: Research

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  18. Zika virus (ZIKV) belongs to the Flavivirus genus of the Flaviviridae family. It is an arbovirus that can cause congenital abnormalities and is sexually transmissible. A series of outbreaks accompanied by unexpec...

    Authors: Muhammad Izzuddin Mohd Ropidi, Ahmad Suhail Khazali, Nurshamimi Nor Rashid and Rohana Yusof

    Citation: Journal of Biomedical Science 2020 27:27

    Content type: Review

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  19. Acinetobacter baumannii (A. baumannii) is an important opportunistic pathogen causing serious nosocomial infections, which is considered as the most threatening Gram-negative bacteria (GNB). Outer membrane protei...

    Authors: Dan Nie, Yue Hu, Zhou Chen, Mingkai Li, Zheng Hou, Xiaoxing Luo, Xinggang Mao and Xiaoyan Xue

    Citation: Journal of Biomedical Science 2020 27:26

    Content type: Review

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  20. Dengue presents a wide clinical spectrum. Most patients recover following a self-limiting non-severe clinical course. A small proportion of patients progress to severe disease, mostly characterized by plasma l...

    Authors: Harsha Hapugaswatta, Pubudu Amarasena, Ranjan Premaratna, Kapila N. Seneviratne and Nimanthi Jayathilaka

    Citation: Journal of Biomedical Science 2020 27:25

    Content type: Research

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  21. Galectin-9 is a β-galactoside-binding protein with two carbohydrate recognition domains. Recent studies have revealed that galectin-9 regulates cellular biological reactions and plays a pivotal role in fibrosi...

    Authors: Yu-An Hsu, Ching-Yao Chang, Joung-Liang Lan, Ju-Pi Li, Hui-Ju Lin, Chih-Sheng Chen, Lei Wan and Fu-Tong Liu

    Citation: Journal of Biomedical Science 2020 27:24

    Content type: Research

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  22. Recent advancements in cancer biology field suggest that glucose metabolism is a potential target for cancer treatment. However, little if anything is known about the metabolic profile of cancer stem cells (CS...

    Authors: Han-Shui Hsu, Chen-Chi Liu, Jiun-Han Lin, Tien-Wei Hsu, Jyuan-Wei Hsu, Anna Fen-Yau Li and Shih-Chieh Hung

    Citation: Journal of Biomedical Science 2020 27:5

    Content type: Research

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  23. Enterovirus 71 (EV-A71) is one of the major causative agents of hand, foot, and mouth disease. EV-A71 infection is sometimes associated with severe neurological diseases such as acute encephalitis, acute flacc...

    Authors: Kyousuke Kobayashi and Satoshi Koike

    Citation: Journal of Biomedical Science 2020 27:23

    Content type: Review

    Published on:

  24. Stress-induced analgesia (SIA) is an evolutionarily conserved phenomenon during stress. Neuropeptide S (NPS), orexins, substance P, glutamate and endocannabinoids are known to be involved in stress and/or SIA,...

    Authors: Ming Tatt Lee, Yu-Ting Chiu, Yu-Chun Chiu, Chia Chun Hor, Hsin-Jung Lee, Remo Guerrini, Girolamo Calo and Lih-Chu Chiou

    Citation: Journal of Biomedical Science 2020 27:7

    Content type: Research

    Published on:

  25. Upon EV-A71 infection of a host cell, EV-A71 RNA is translated into a viral polyprotein. Although EV-A71 can use the cellular translation machinery to produce viral proteins, unlike cellular translation, which...

    Authors: Ming-Chih Lai, Han-Hsiang Chen, Peng Xu and Robert Y. L. Wang

    Citation: Journal of Biomedical Science 2020 27:22

    Content type: Review

    Published on:

  26. Polyethylene glycol (PEG) is widely used in industry and medicine. Anti-PEG antibodies have been developed for characterizing PEGylated drugs and other applications. However, the underlying mechanism for speci...

    Authors: Cheng-Chung Lee, Yu-Cheng Su, Tzu-Ping Ko, Li-Ling Lin, Chih-Ya Yang, Stanley Shi-Chung Chang, Steve R. Roffler and Andrew H.-J. Wang

    Citation: Journal of Biomedical Science 2020 27:12

    Content type: Research

    Published on:

  27. Melatonin (5-methoxy-N-acetyltryptamine), a hormone produced in the pineal gland, has a variety of biological functions as an antioxidant, but a functional role of melatonin in the regulation of intestinal muc...

    Authors: Young-Min Lee, Jong Pil Park, Young Hyun Jung, Hyun Jik Lee, Jun Sung Kim, Gee Euhn Choi, Ho Jae Han and Sei-Jung Lee

    Citation: Journal of Biomedical Science 2020 27:21

    Content type: Research

    Published on:

  28. Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), affecting approximately one third of the world’s population. Development of an adequate immune response will determine disease progres...

    Authors: María Belén Vecchione, Natalia Laufer, Omar Sued, Marcelo Corti, Horacio Salomon and Maria Florencia Quiroga

    Citation: Journal of Biomedical Science 2020 27:20

    Content type: Research

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  29. The FDA approved drug granulocyte-colony stimulating factor (G-CSF) displays anti-apoptotic and immunomodulatory properties with neurogenesis and angiogenic functions. It is known to demonstrate neuroprotectiv...

    Authors: Jigar Modi, Janet Menzie-Suderam, Hongyuan Xu, Paola Trujillo, Kristen Medley, Michael L. Marshall, Rui Tao, Howard Prentice and Jang-Yen Wu

    Citation: Journal of Biomedical Science 2020 27:19

    Content type: Research

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  30. Alzheimer disease (AD) accounts for 60–70% of dementia cases. Given the seriousness of the disease and continual increase in patient numbers, developing effective therapies to treat AD has become urgent. Prese...

    Authors: Li-Kai Huang, Shu-Ping Chao and Chaur-Jong Hu

    Citation: Journal of Biomedical Science 2020 27:18

    Content type: Review

    Published on:

  31. Influenza A viruses cause epidemics/severe pandemics that pose a great global health threat. Among eight viral RNA segments, the multiple functions of nucleoprotein (NP) play important roles in viral replicati...

    Authors: Su-Jhen Hung, Yin-Mei Hsu, Sheng-Wen Huang, Huey-Pin Tsai, Leo Yi Yang Lee, Aeron C. Hurt, Ian G. Barr, Shin-Ru Shih and Jen-Ren Wang

    Citation: Journal of Biomedical Science 2020 27:17

    Content type: Research

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  32. Over-stimulation of dopamine signaling is thought to underlie the pathophysiology of a list of mental disorders, such as psychosis, mania and attention-deficit/hyperactivity disorder. These disorders are frequ...

    Authors: Pi-Kai Chang, Jung Chu, Ya-Ting Tsai, Yan-Heng Lai and Jin-Chung Chen

    Citation: Journal of Biomedical Science 2020 27:16

    Content type: Research

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  33. Extraintestinal pathogenic E. coli (ExPEC) remains one of the most prevalent bacterial pathogens that cause extraintestinal infections, including neonatal meningitis, septicemia, and urinary tract (UT) infections...

    Authors: Wen-Chun Huang, Chung-Yen Lin, Masayuki Hashimoto, Jiunn-Jong Wu, Ming-Cheng Wang, Wei-Hung Lin, Chang-Shi Chen and Ching-Hao Teng

    Citation: Journal of Biomedical Science 2020 27:14

    Content type: Research

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  34. Detection of cholangiocarcinoma (CCA) remains a diagnostic challenge. We established diagnostic peptide biomarkers in bile and urine based on capillary electrophoresis coupled to mass spectrometry (CE-MS) to d...

    Authors: Torsten Voigtländer, Jochen Metzger, Holger Husi, Martha M. Kirstein, Martin Pejchinovski, Agnieszka Latosinska, Maria Frantzi, William Mullen, Thorsten Book, Harald Mischak and Michael P. Manns

    Citation: Journal of Biomedical Science 2020 27:13

    Content type: Research

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  35. Circular RNAs (circRNAs) represent a class of non-coding RNAs (ncRNAs) which are widely expressed in mammals and tissue-specific, of which some could act as critical regulators in the atherogenesis of cerebrov...

    Authors: Shanchao Zhang, Guixiang Song, Jing Yuan, Shan Qiao, Shan Xu, Zhihua Si, Yang Yang, Xuxu Xu and Aihua Wang

    Citation: Journal of Biomedical Science 2020 27:11

    Content type: Research

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  36. Bacterial isolates with multiple plasmids harbouring different carbapenemase genes have emerged and been identified repeatedly, despite a general notion that plasmids confer fitness cost in bacterial host. In ...

    Authors: Haejeong Lee, Juyoun Shin, Yeun-Jun Chung, Myungseo Park, Kyeong Jin Kang, Jin Yang Baek, Dongwoo Shin, Doo Ryeon Chung, Kyong Ran Peck, Jae-Hoon Song and Kwan Soo Ko

    Citation: Journal of Biomedical Science 2020 27:8

    Content type: Research

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  37. Today, the treatment of bacterial infections is a major challenge, due to growing rate of multidrug-resistant bacteria, complication of treatment and increased healthcare costs. Moreover, new treatments for ba...

    Authors: Shima Afrasiabi, Maryam Pourhajibagher, Reza Raoofian, Maryam Tabarzad and Abbas Bahador

    Citation: Journal of Biomedical Science 2020 27:6

    Content type: Review

    Published on:

  38. Dengue virus (DENV) is the etiological agent of dengue fever. Severe dengue could be fatal and there is currently no effective antiviral agent or vaccine. The only licensed vaccine, Dengvaxia, has low efficacy...

    Authors: Rui Rui Wong, Noraini Abd-Aziz, Sarah Affendi and Chit Laa Poh

    Citation: Journal of Biomedical Science 2020 27:4

    Content type: Review

    Published on:

  39. Serglycin (SRGN), previously recognized as an intracellular proteoglycan involved in the storage processes of secretory granules, has recently been shown to be upregulated in several solid tumors. We have prev...

    Authors: Jing-You Guo, Chu-Hsuan Chiu, Mei-Jung Wang, Fu-An Li and Jeou-Yuan Chen

    Citation: Journal of Biomedical Science 2020 27:2

    Content type: Research

    Published on:

  40. It has been more than three decades since the first monoclonal antibody was approved by the United States Food and Drug Administration (US FDA) in 1986, and during this time, antibody engineering has dramatica...

    Authors: Ruei-Min Lu, Yu-Chyi Hwang, I-Ju Liu, Chi-Chiu Lee, Han-Zen Tsai, Hsin-Jung Li and Han-Chung Wu

    Citation: Journal of Biomedical Science 2020 27:1

    Content type: Review

    Published on:

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