Figure 2

Protein expression patterns of p300 and CBP in early embryonic hearts. Lateral view of E7.5 embryo shows a high expression of p300 in cardiac crescents (arrow) at the anterior of the embryo (A). No expression of CBP was detected in cardiac crescents of a E7.5 embryo (arrow)(B). Lateral view of E8.5 embryo shows a high expression of p300 in linear heart tube at midline of the embryo including endocardium primordium (arrow) and myoepicardial mantle (arrowhead) which are the presumptive regions of myocardium and epicardium (C). Lateral view of E8.5 embryo shows a relatively low expression of CBP in the endocardium primordium (arrow) and myoepicardial mantle (arrowhead)(D). Lateral view of E9.5 embryo shows a high expression of p300 in looping heart tube at the left of the embryo including endocardium primordium (arrow) and myoepicardial mantle (arrowhead)(E). Lateral view of E9.5 embryo shows a relatively low expression of CBP in the looping heart tube including endocardium primordium (arrow) and myoepicardial mantle (arrowhead). Magnification: ×200.