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Table 1 Effects of genistein, EGF, 17β-estradiol and combinations of genistein with EGF or 17β-estradiol on accumulation of lysosomes containing complex storage structures in MPS IIIA fibroblasts

From: Genistein-mediated inhibition of glycosaminoglycan synthesis, which corrects storage in cells of patients suffering from mucopolysaccharidoses, acts by influencing an epidermal growth factor-dependent pathway

Cells Added agents a Average number of complex storage structures per 100 μm2
  Genistein (μM) EGF (ng/ml) 17β-estradiol (nM)  
Control 0 0 0 2
MPS IIIA 0 0 0 38
MPS IIIA 10 0 0 7
MPS IIIA 30 0 0 5
MPS IIIA 0 100 0 67
MPS IIIA 10 100 0 26
MPS IIIA 30 100 0 11
MPS IIIA 0 0 1 21
MPS IIIA 10 0 1 13
MPS IIIA 30 0 1 8
  1. a Electron micrographs obtained as shown in Fig. 2 were analyzed by counting complex storage structures per 100 μm2.