Skip to main content

Table 1 Mechanisms of hepatic tumor-immune escape.

From: Immunotherapy for liver tumors: present status and future prospects

Attack

Defense

System

Mechanism

Ref.

System

Mechanism

Ref.

Fas/FasL

T-cell apoptosis

66

Tregs

Immunosuppression

73

PD-1/PD-1L

T-cell apoptosis

69

MHC-I

Antigen presentation

75

Galectin-1

T-cell apoptosis

72

B7-1/B7-2

Antigen presentation

76

   

IDO

Immunosuppression

82

  1. Two main strategies to escape from the immune response attack and defense have been demonstrated for HCC in experimental and/or clinical setting. Fas: CD95; FasL: CD95L; PD-1: programmed death-1; PD-1L: programmed death-1 ligand; Tregs: Regulatory T cells; IDO: Indoleamine 2,3 dioxygenase.
Back to article page

Journal of Biomedical Science

ISSN: 1423-0127