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Table 5 Scatchard analysis of [3H] QNB binding against pirenzepine in the corpus striatum of Control, Diabetic and Diabetic+Insulin treated group rats

From: Enhanced muscarinic M1 receptor gene expression in the corpus striatum of streptozotocin-induced diabetic rats

Animal status

Bmax (fmoles/mg protein)

Kd (nM)

Control

1460.00 ± 30.55

1.34 ± 0.02

Diabetic

2060.00 ± 30.55***

0.45 ± 0.02***

Diabetic + Insulin treated

1550.00 ± 28.86ψψψ

0.56 ± 0.01

  1. Values are mean ± S.E.M of 4–6 separate experiments. Each group consist of 6–8 rats
  2. *** P < 0.001 when compared to control, ψψψ P < 0.001 when compared to diabetic group