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Table 3 The non-disjunction resulting from mars loss-of-function is enhanced by reduced tlk activity

From: mars and tousled-like kinase act in parallel to ensure chromosome fidelity in Drosophila

Genotype of mothers

Number of male progeny

y- w- sn- male progeny

w 1118

979

0 (0.0%)

w1118; marsP

476

374*

3 (0.6%)

4 (1.1%)

w67c23tlk27-9/w1118

579

0 (0.0%)

w67c23tlkΔ14/w1118

909

1071*

1 (0.1%)

4 (0.4%)

w67c23tlk27-9/w1118;marsP/+

997

636*

1 (0.1%)

1 (0.2%)

w67c23tlkΔ14/w1118;marsP/+

838

1170*

0 (0.0%)

3 (0.3%)

w67c23tlk27-9/w1118;marsP

398

411*

5 (1.2%)

25 (6.1%#)

w1118tlkΔ14/w1118;marsP

926

1188*

5 (0.5%)

52 (4.4%#)

  1. Ten to twelve 2-day old females with the genotypes indicated in the left column were crossed with y1w1sn3; marsPmales. Each cross was set up in at least five vials and transferred into new vials after three days. After the second transfer, the parents were discarded. The flies were incubated at 24°C or 28.5°C ± 0.5°C. The latter is indicated by an asterisk. Male progenies were counted for five consecutive days. The percentage of y- w- sn- offspring over total males is shown in parenthesis. Number sign, #, represents a significant difference between marsPand tlk27-9 or Δ14/+;marsPat 28.5°C as determined by the Student's t-test (p < 0.01).
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Journal of Biomedical Science

ISSN: 1423-0127