Figure 2
From: Identification of non-muscle myosin heavy chain as a substrate for Cdk5 and tool for drug screening
Cdk5 inhibitors dose-dependently inhibit peptide substrate phosphorylation in a SPA assay. A. Roscovitine dose-dependently inhibits substrate phosphorylation with IC50 280 nM. B. WL compound dose-dependently inhibits substrate phosphorylation with IC50 45 nM. C. AZ compound dose-dependently inhibits substrate phosphorylation with IC50 355 nM. Structures of these compounds are shown next to their respective inhibition curves.