Time-course changes in MSAP or HR after systemic injection of Escherichia coli . lipopolysaccharide (LPS, 15 mg/kg) or saline (n = 7) in rats that were maintained under propofol anesthesia (15 or 30 mg/kg/h; n = 7 or 8). Values are mean ± SEM, n = 7 or 8 animals per experimental groups. *P < 0.05 vs. propofol + saline group and #P < 0.05 vs. low dose (15 m/kg/h) propofol group at corresponding time points in the Scheffé multiple-range test. The data of propofol (30 mg/kg/h) + saline group were not shown because they were similar to that of propofol (15 mg/kg/h) + saline group.