Effects of honokiol and magnolol on glutamate-induced nociceptive responses and thermal hyperalgesia in mice. Honokiol (5 and 10 mg/kg), magnolol (5 and 10 mg/kg) and vehicle (corn oil) were intraperitoneally administered 20 min prior to glutamate (300 μg) injection into hindpaw, and the total time spent licking the hindpaw was measured for 30 min after intraplantar injection of glutamate (A, B). The paw withdrawal latency in hot water at 47°C was measured during 5-120 min after intraplantar injection of glutamate (C, D). Each point represents the mean ± S.E.M. (n = 6-8). * indicates significantly different from vehicle group, *p < 0.05.