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Table 5 Effects of ischemia-hypoxia and ischemia-hyperoxia in the hippocampus of young rats

From: Region-specific effects on brain metabolites of hypoxia and hyperoxia overlaid on cerebral ischemia in young and old rats: a quantitative proton magnetic resonance spectroscopy study

Metabolite

Control

Ischemia-hypoxia

Ischemia-hyperoxia

Right

Left

Right

Left

Alanine

0.89 ± 0.08

0.43 ± 0.02*

0.37 ± 0.05*

0.70 ± 0.20

0.85 ± 0.03

Choline

4.11 ± 0.12

2.20 ± 0.45**

2.48 ± 0.11**

3.48 ± 0.45

3.77 ± 0.17

Creatine

11.96 ± 0.20

8.95 ± 0.48*

8.28 ± 0.62**

10.50 ± 1.50

11.08 ± 0.23

GABA

2.12 ± 0.12

0.73 ± 0.16**

0.88 ± 0.24**

2.07 ± 0.35

1.82 ± 0.09

Glutamate

14.93 ± 0.71

9.27 ± 1.50*

8.77 ± 0.81**

12.36 ± 1.50

11.33 ± 0.70**

Lactate

14.63 ± 0.22

12.45 ± 1.50*

12.23 ± 0.80*

16.57 ± 0.45**

15.44 ± 0.15*

Myo-inositol

7.47 ± 0.35

5.26 ± 1.10

5.92 ± 0.20*

7.90 ± 0.80

8.22 ± 0.38

N-acetylaspartate

9.70 ± 0.12

6.88 ± 1.40*

6.81 ± 0.24*

8.67 ± 1.20

8.79 ± 0.32

  1. Concentrations of metabolites (mmol/kg w/w) in young rats, under normoxic condition (control), ischemia-hypoxia, and ischemia-hyperoxia. Data are means ± SE (n = 10 rats/group). Values, determined by proton MRS as outlined in the Methods, are given for the right (ipsilateral to cerebral ischemic injury) and left (contralateral) hemisphere. *P < 0.05 and **P < 0.01 compared with controls.