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Table 5 Effects of ischemia-hypoxia and ischemia-hyperoxia in the hippocampus of young rats

From: Region-specific effects on brain metabolites of hypoxia and hyperoxia overlaid on cerebral ischemia in young and old rats: a quantitative proton magnetic resonance spectroscopy study

Metabolite Control Ischemia-hypoxia Ischemia-hyperoxia
Right Left Right Left
Alanine 0.89 ± 0.08 0.43 ± 0.02* 0.37 ± 0.05* 0.70 ± 0.20 0.85 ± 0.03
Choline 4.11 ± 0.12 2.20 ± 0.45** 2.48 ± 0.11** 3.48 ± 0.45 3.77 ± 0.17
Creatine 11.96 ± 0.20 8.95 ± 0.48* 8.28 ± 0.62** 10.50 ± 1.50 11.08 ± 0.23
GABA 2.12 ± 0.12 0.73 ± 0.16** 0.88 ± 0.24** 2.07 ± 0.35 1.82 ± 0.09
Glutamate 14.93 ± 0.71 9.27 ± 1.50* 8.77 ± 0.81** 12.36 ± 1.50 11.33 ± 0.70**
Lactate 14.63 ± 0.22 12.45 ± 1.50* 12.23 ± 0.80* 16.57 ± 0.45** 15.44 ± 0.15*
Myo-inositol 7.47 ± 0.35 5.26 ± 1.10 5.92 ± 0.20* 7.90 ± 0.80 8.22 ± 0.38
N-acetylaspartate 9.70 ± 0.12 6.88 ± 1.40* 6.81 ± 0.24* 8.67 ± 1.20 8.79 ± 0.32
  1. Concentrations of metabolites (mmol/kg w/w) in young rats, under normoxic condition (control), ischemia-hypoxia, and ischemia-hyperoxia. Data are means ± SE (n = 10 rats/group). Values, determined by proton MRS as outlined in the Methods, are given for the right (ipsilateral to cerebral ischemic injury) and left (contralateral) hemisphere. *P < 0.05 and **P < 0.01 compared with controls.