|
Metabolite
|
Control
|
Ischemia-hypoxia
|
Ischemia-hyperoxia
|
|---|
|
Right
|
Left
|
Right
|
Left
|
|---|
|
Alanine
|
0.91 ± 0.12
|
0.37 ± 0.05*
|
0.38 ± 0.07*
|
1.28 ± 0.36
|
1.01 ± 0.23
|
|
Choline
|
4.27 ± 0.08
|
2.56 ± 0.40***
|
2.69 ± 0.18***
|
4.03 ± 0.28
|
4.03 ± 0.26
|
|
Creatine
|
12.69 ± 0.32
|
7.52 ± 0.90*
|
7.80 ± 0.75**
|
12.31 ± 0.41
|
11.68 ± 0.58
|
|
GABA
|
2.65 ± 0.24
|
1.38 ± 0.39**
|
1.66 ± 0.23**
|
3.22 ± 0.48
|
2.69 ± 0.31
|
|
Glutamate
|
15.53 ± 0.44
|
6.97 ± 0.96***
|
6.88 ± 0.48***
|
12.67 ± 1.40*
|
13.06 ± 1.00**
|
|
Lactate
|
16.24 ± 0.34
|
12.69 ± 1.42***
|
11.38 ± 0.55***
|
17.05 ± 0.26*
|
17.03 ± 1.00*
|
|
Myo-inositol
|
8.26 ± 0.45
|
5.27 ± 1.15*
|
5.87 ± 0.66**
|
8.75 ± 0.50
|
9.01 ± 0.56
|
|
N-acetylaspartate
|
10.51 ± 0.18
|
6.35 ± 0.45***
|
6.00 ± 0.42***
|
9.41 ± 0.37
|
9.13 ± 0.46
|
- Concentrations of metabolites (mmol/kg w/w) in aged rats, under normoxic condition (control), ischemia-hypoxia, and ischemia-hyperoxia. Data are means ± SE (n = 10 rats/group). Values, determined by proton MRS as outlined in the Methods, are given for the right (ipsilateral to cerebral ischemic injury) and left (contralateral) hemisphere. *P < 0.05, **P < 0.01, and ***P < 0.001 compared with controls.
