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Table 6 Effects of ischemia-hypoxia and ischemia-hyperoxia in the hippocampus of aged rats

From: Region-specific effects on brain metabolites of hypoxia and hyperoxia overlaid on cerebral ischemia in young and old rats: a quantitative proton magnetic resonance spectroscopy study

Metabolite Control Ischemia-hypoxia Ischemia-hyperoxia
Right Left Right Left
Alanine 0.91 ± 0.12 0.37 ± 0.05* 0.38 ± 0.07* 1.28 ± 0.36 1.01 ± 0.23
Choline 4.27 ± 0.08 2.56 ± 0.40*** 2.69 ± 0.18*** 4.03 ± 0.28 4.03 ± 0.26
Creatine 12.69 ± 0.32 7.52 ± 0.90* 7.80 ± 0.75** 12.31 ± 0.41 11.68 ± 0.58
GABA 2.65 ± 0.24 1.38 ± 0.39** 1.66 ± 0.23** 3.22 ± 0.48 2.69 ± 0.31
Glutamate 15.53 ± 0.44 6.97 ± 0.96*** 6.88 ± 0.48*** 12.67 ± 1.40* 13.06 ± 1.00**
Lactate 16.24 ± 0.34 12.69 ± 1.42*** 11.38 ± 0.55*** 17.05 ± 0.26* 17.03 ± 1.00*
Myo-inositol 8.26 ± 0.45 5.27 ± 1.15* 5.87 ± 0.66** 8.75 ± 0.50 9.01 ± 0.56
N-acetylaspartate 10.51 ± 0.18 6.35 ± 0.45*** 6.00 ± 0.42*** 9.41 ± 0.37 9.13 ± 0.46
  1. Concentrations of metabolites (mmol/kg w/w) in aged rats, under normoxic condition (control), ischemia-hypoxia, and ischemia-hyperoxia. Data are means ± SE (n = 10 rats/group). Values, determined by proton MRS as outlined in the Methods, are given for the right (ipsilateral to cerebral ischemic injury) and left (contralateral) hemisphere. *P < 0.05, **P < 0.01, and ***P < 0.001 compared with controls.