Sodium valproate-induced congenital cardiac abnormalities in mice are associated with the inhibition of histone deacetylase

Table 1 Fetal loss and cardiac abnormality in NaVP exposed dams

Treatment (Gestation)	No. of dams	Total No. of Live fetuses (fetus/dam)	N. of death or resorption	Cardiac abnormalities
				No. in live fetus	%
Day 6
Control	10	163 (16.3)	2	1	0.60
Treated	20	148 (7.4)*	63*	13	8.70*
Day 7
Control	12	148 (12.3)	3	1	0.67
Treated	24	162 (6.75)*	90*	34	20.90*
Day 8
Control	10	147 (14.7)	3	0	0.00
Treated	20	132 (6.6)*	78*	13	9.80*
Day 9
Control	10	149 (14.9)	1	1	0.68
Treated	20	142 (7.1)*	60*	9	6.30*

Pregnant female mice received a one-time injection (i.p.) of NaVP (700 mg/kg body weight) on gestation day as indicated. The fetuses were examined on gestation day 19 after sacrifice of the pregnant mice as described in Materials and Methods.
* P < 0.05 compared to controls.

ISSN: 1423-0127