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Figure 4 | Journal of Biomedical Science

Figure 4

From: Akt regulates the expression of MafK, synaptotagmin I, and syntenin-1, which play roles in neuronal function

Figure 4

Effect of a Gsk3β inhibitor on gene expression in PC12 (DN-Akt) cells. PC12 (DN-Akt) cells were treated with 10 μM TWS119, a Gsk3β inhibitor for three hours. (A) Western blot analysis of β-catenin in PC12 (DN-Akt) cells treated with TWS119 to confirm that this agent works actively as a Gsk3β inhibitor in our experimental conditions. (B) mRNA levels for each gene are presented as a fold difference over that of vehicle-treated cells. *P < 0.05 (n = 3-4, mean + SD). (C) Western blot analysis of Syn-1 protein. Veh, vehicle; Inh, inhibitor.

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Journal of Biomedical Science

ISSN: 1423-0127