Figure 3
Effects of simvastatin on (A and D) p38 MAPK, (B) JNKs, and (C) ERKs phosphorylation in activated platelets. Washed platelets (1.2 × 109/ml) were preincubated with simvastatin (30 and 50 μM) or 0.5% DMSO, followed by the addition of collagen (1 μg/ml) to trigger (A and D) p38 MAPK, (B) JNKs, and (C) ERKs phosphorylation. Data are presented as the means ± S.E.M. (n = 4); *P < 0.05 and **P < 0.01, compared to the control group; #P < 0.05, compared to the collagen group.