Figure 2

Effects of ceftriaxone on GLT1 expression in cerebral cortex and striatum at 13 weeks of age. Immunoblots (A, C) and quantitative analysis (B, D) of the percentage ratio of GLT1/β-tubulin in cerebral cortex and striatum, respectively (**P < 0.01 and ***P < 0.001 relative to corresponding saline group). Note the reduction in the percentage ratio of GLT1/β-tubulin expression in cerebral cortex (**P < 0.01) and striatum (*P < 0.05) of saline-treated R6/2 mice relative to saline-treated WT mice, and the elimination of this effect after ceftriaxone. Error bars indicate SEM. (N = 5 for each group).