Evidence of d-phenylglycine as delivering tool for improving l-dopa absorption

Table 1 Plasma concentrations of d-phenylglycine-l-dopa and l-dopa measured in in situ single-pass jejunal perfusion experiments.

Compound	No. of Experiments	Pm*	Blood concentration (μg/ml)	Molar ratio of blood concentration (μg/ml)
d-phenylglycine-l-dopa	4	2.58 ± 0.14	64.6 ± 5.40	31.10
l-dopa	3	0.94 ± 0.10	1.24^a	1.02

^a l-dopa was detected only in the plasma sample from one of the three rats tested. It was below detection limit in plasma samples of the other two rats. Data presented are mean ± SD of n experiments.

ISSN: 1423-0127