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Table 1 Serotonin and metabolites in the hippocampus of control and experimental rats

From: Alterations in hippocampal serotonergic and INSR function in streptozotocin induced diabetic rats exposed to stress: neuroprotective role of pyridoxine and Aegle marmelose

Experimental Groups

5-HT

(nmoles/g wet wt. of tissue)

5HIAA

(nmoles/g wet wt. of tissue)

5-HIAA/

5-HT

Control

1.56 ± 0.27

1.94 ± 0.22

1.24 ± 0.23

Diabetic

0.89 ± 0.29 a

2.93 ± 0.31 a

3.29 ± 0.28 a

Diabetic+Insulin

1.07 ± 0.19 a, b

2.29 ± 0.20 a, b

2.14 ± 0.20 a

Diabetic+Pyridoxine

0.98 ± 0.33 a, b

2.91 ± 0.36 a

2.96 ± 0.33 a

Diabetic+Insulin+Pyridoxine

1.45 ± 0.35 c

1.53 ± 0.29 c

1.05 ± 0.31 c

Diabetic+ A. marmelose

1.10 ± 0.23 a, b

2.73 ± 0.24 a, b

2.48 ± 0.21 a

Diabetic+ A. marmelose +Pyridoxine

1.59 ± 0.22 c

1.66 ± 0.22 c

1.04 ± 0.21 c

  1. Values are mean ± S.E.M of 4-6 separate experiments. Each group consists of 6-8 rats.
  2. a p < 0.001 when compared to control;
  3. b p < 0.01, c p < 0.001 when compared to diabetic group.