Skip to main content

Table 2 Haplotypes according to the presence of phospholipase A2 receptor 1 (PLA2R1) single nucleotide polymorphisms (SNPs) in patients with idiopathic membranous nephropathy (IMN) vs healthy controls

From: Association of phospholipase A2 receptor 1 polymorphisms with idiopathic membranous nephropathy in Chinese patients in Taiwan

Polymorphisms Controls
N (%)
IMN
N (%)
p-Value Odds ratio (95% CI)e
Haplotype a
H1-TG 84 (39.6) 134 (51.9) 0.004b 1.647 (1.140-2.379)
H2-CG 72 (34.0) 83 (32.2)   0.922 (0.627-1.357)
H3-TC 52 (24.5) 41 (15.9)   0.581 (0.368-0.919)
H4-CC 4 (1.9) 0 (0.0)   0.005 (0.000-)
Diplotypes a
H1/H1 + H1/nonH1 67 (63.2) 99 (76.7) 0.023c 1.921 (1.088-3.390)
H1/H1 17 (16.0) 35 (27.1) 0.031d 2.676 (1.264-5.665)
H1/nonH1 54 (47.2) 64 (49.6)   1.664 (0.911-3.041)
nonH1/nonH1 39 (36.8) 30 (23.3)   1
H2/H2 + H2/nonH2 64 (60.4) 68 (52.7) 0.239c 1.921 (1.088-3.390)
H2/H2 8 (7.5) 15 (11.6) 0.174d 2.676 (1.264-5.665)
H2/nonH2 56 (52.8) 53 (41.1)   1.664 (0.911-3.041)
nonH2/nonH2 42 (39.6) 61 (47.3)   1
H3/H3 + H3/nonH3 47 (44.3) 39 (30.2) 0.025c 0.544 (0.318-0.930)
H3/H3 5 (4.7) 2 (1.6) 0.053d 0.262 (0.049-1.396)
H3/nonH3 42 (39.6) 37 (28.7)   0.578 (0.333-1.002)
nonH3/nonH3 59 (55.7) 90 (69.8)   1
H4/H4 + H4/nonH4 4 (3.8) 0 (0.0) 0.026c 0.000 (0.000-)
H4/H4 0 (0.0) 0 (0.0) 0.026d --
H4/nonH4 4 (3.8) 0 (0.0)   0.000 (0.000-)
nonH4/nonH4 102 (96.2) 129 (100.0)   1
  1. Abbreviations: CI, confidence interval; H, haplotype.
  2. a Order of SNPs comprising the PLA2R1 haplotypes: rs6757188, and rs35771982. The haplotypes were identified by the Baysian statistical method available in the program Phase 2.1.
  3. b The significance of haplotype frequency for IMN development was determined by chi-square test using 4 × 2 contingency tables.
  4. c Individual haplotype frequencies for IMN development were determined by chi-square test using 2 × 2 contingency tables.
  5. d The significance of diplotype frequency for IMN development were determined by chi-square test using 3 × 2 contingency tables.
  6. e Odds ratios and 95% CI per haplotype or diplotype were estimated by applying unconditional logistic regression between patients with IMN and healthy controls.