Association of phospholipase A2 receptor 1 polymorphisms with idiopathic membranous nephropathy in Chinese patients in Taiwan

Table 2 Haplotypes according to the presence of phospholipase A2 receptor 1 (PLA2R1) single nucleotide polymorphisms (SNPs) in patients with idiopathic membranous nephropathy (IMN) vs healthy controls

Polymorphisms	Controls N (%)	IMN N (%)	p-Value	Odds ratio (95% CI)^e
Haplotype ^a
H1-TG	84 (39.6)	134 (51.9)	0.004^b	1.647 (1.140-2.379)
H2-CG	72 (34.0)	83 (32.2)		0.922 (0.627-1.357)
H3-TC	52 (24.5)	41 (15.9)		0.581 (0.368-0.919)
H4-CC	4 (1.9)	0 (0.0)		0.005 (0.000-)
Diplotypes ^a
H1/H1 + H1/nonH1	67 (63.2)	99 (76.7)	0.023^c	1.921 (1.088-3.390)
H1/H1	17 (16.0)	35 (27.1)	0.031^d	2.676 (1.264-5.665)
H1/nonH1	54 (47.2)	64 (49.6)		1.664 (0.911-3.041)
nonH1/nonH1	39 (36.8)	30 (23.3)		1
H2/H2 + H2/nonH2	64 (60.4)	68 (52.7)	0.239^c	1.921 (1.088-3.390)
H2/H2	8 (7.5)	15 (11.6)	0.174^d	2.676 (1.264-5.665)
H2/nonH2	56 (52.8)	53 (41.1)		1.664 (0.911-3.041)
nonH2/nonH2	42 (39.6)	61 (47.3)		1
H3/H3 + H3/nonH3	47 (44.3)	39 (30.2)	0.025^c	0.544 (0.318-0.930)
H3/H3	5 (4.7)	2 (1.6)	0.053^d	0.262 (0.049-1.396)
H3/nonH3	42 (39.6)	37 (28.7)		0.578 (0.333-1.002)
nonH3/nonH3	59 (55.7)	90 (69.8)		1
H4/H4 + H4/nonH4	4 (3.8)	0 (0.0)	0.026^c	0.000 (0.000-)
H4/H4	0 (0.0)	0 (0.0)	0.026^d	--
H4/nonH4	4 (3.8)	0 (0.0)		0.000 (0.000-)
nonH4/nonH4	102 (96.2)	129 (100.0)		1

Abbreviations: CI, confidence interval; H, haplotype.
^a Order of SNPs comprising the PLA2R1 haplotypes: rs6757188, and rs35771982. The haplotypes were identified by the Baysian statistical method available in the program Phase 2.1.
^b The significance of haplotype frequency for IMN development was determined by chi-square test using 4 × 2 contingency tables.
^c Individual haplotype frequencies for IMN development were determined by chi-square test using 2 × 2 contingency tables.
^d The significance of diplotype frequency for IMN development were determined by chi-square test using 3 × 2 contingency tables.
^e Odds ratios and 95% CI per haplotype or diplotype were estimated by applying unconditional logistic regression between patients with IMN and healthy controls.

ISSN: 1423-0127