Neuroprotective effects of SBG against D-galactose and NaNO
induced senescent mice. Representive photomicrographs of Cresyl violet-stained neuropathological changes in the hippocampus regions of senescent mice. In NC group, the neurons were full and arranged tightly, the nuclei are light-stained (NC). Cytoplasm of neurons of AC group was shrunken, the nuclei were side-moved and dark-stained, vacuoles were observed everywhere (AC). In the treatment group with 50 mg/kg or 100 mg/kg of SBG, the neurons were normalized, the nuclei were light-stained and arranged tightly and in the high dose group that is seen apparently (SBG50 and SBG100). Neuronal cell density in hippocampus region was measured by Nissl staining and cell counting.