Figure 4From: Protein kinases modulate store-operated channels in pulmonary artery smooth muscle cellsPKA inhibition by H-89 augments SOC whole cell currents. Using whole cell patch clamp electrophysiology, PASMCs were voltage clamped and then periodically exposed to a step protocol (-80 mV to +20 mV, 20 mV increments, 300 ms duration) in the absence and presence of 10 μM H-89 ± 10 μM SKF-96365 (SKF) or 0.1 mM Ni2+. A representative trace and summary data can be found in A &B, respectively. Data are means ± SE, n = 6. * and # denote significant difference from control and H-89, respectively.Back to article page