Diagram highlighting protein kinase modulation of SOCs in rat PASMCs. Note that protein kinase G (PKG) and protein kinase A (PKA) inhibit SOC currents whereas protein kinase C (PKC) appears to activate SOC currents. PKC activation of SOC currents is augmented by phospholipase C (PLC) activation and the production of Ins(1,4,5)P
. AC, adenylate cyclase; sGC, soluble guanylate cyclase.