Figure 7
From: Protein kinases modulate store-operated channels in pulmonary artery smooth muscle cells
Diagram highlighting protein kinase modulation of SOCs in rat PASMCs. Note that protein kinase G (PKG) and protein kinase A (PKA) inhibit SOC currents whereas protein kinase C (PKC) appears to activate SOC currents. PKC activation of SOC currents is augmented by phospholipase C (PLC) activation and the production of Ins(1,4,5)P 3 . AC, adenylate cyclase; sGC, soluble guanylate cyclase.