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Table 3 The ten most upregulated and down regulated BPH-1 genes in response to stroma, in 3D culture

From: Stromal upregulation of lateral epithelial adhesions: Gene expression analysis of signalling pathways in prostate epithelium

Gene Symbol Gene Title Fold change Probe ID
MAP7D2 MAP7 domain containing 2 2.866 228262_at
IGFBP3 insulin-like growth factor binding protein 3 2.613 212143_s_at
IGFBP3 insulin-like growth factor binding protein 3 2.600 210095_s_at
STON1 stonin 1 2.527 213413_at
BEAN brain expressed, associated with Nedd4 2.446 214068_at
FBXO32 F-box protein 32 2.290 225803_at
GNG7 guanine nucleotide binding protein (G protein), gamma 7 2.277 228831_s_at
NOTCH3 Notch homolog 3 (Drosophila) 2.264 203238_s_at
MB myoglobin 2.258 204179_at
CLIC3 chloride intracellular channel 3 2.225 219529_at
KRT6A /// KRT6B /// KRT6C keratin 6A /// keratin 6B /// keratin 6C -3.099 214580_x_at
NNMT nicotinamide N-methyltransferase -3.126 202237_at
KIAA1199 KIAA1199 -3.183 212942_s_at
KRT6A keratin 6A -3.215 209125_at
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -3.450 204818_at
KRT14 keratin 14 -3.460 209351_at
SERPINB3 /// SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 3 /// serpin peptidase inhibitor, clade B (ovalbumin), member 4 -8.311 210413_x_at
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 -9.406 209719_x_at
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 -12.240 209720_s_at
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -17.045 211906_s_at
  1. *Values are mean fold expression changes of three BPH-1 cultures abstracted from Affymetrix datasets. All genes showed significant differential expression (p < 0.05). Positive values indicate upregulation, negative values indicate down regulated genes in the epithelial cells. Hypothetical or unassigned genes were removed from the list.