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Table 3 The ten most upregulated and down regulated BPH-1 genes in response to stroma, in 3D culture

From: Stromal upregulation of lateral epithelial adhesions: Gene expression analysis of signalling pathways in prostate epithelium

Gene Symbol

Gene Title

Fold change

Probe ID

MAP7D2

MAP7 domain containing 2

2.866

228262_at

IGFBP3

insulin-like growth factor binding protein 3

2.613

212143_s_at

IGFBP3

insulin-like growth factor binding protein 3

2.600

210095_s_at

STON1

stonin 1

2.527

213413_at

BEAN

brain expressed, associated with Nedd4

2.446

214068_at

FBXO32

F-box protein 32

2.290

225803_at

GNG7

guanine nucleotide binding protein (G protein), gamma 7

2.277

228831_s_at

NOTCH3

Notch homolog 3 (Drosophila)

2.264

203238_s_at

MB

myoglobin

2.258

204179_at

CLIC3

chloride intracellular channel 3

2.225

219529_at

KRT6A /// KRT6B /// KRT6C

keratin 6A /// keratin 6B /// keratin 6C

-3.099

214580_x_at

NNMT

nicotinamide N-methyltransferase

-3.126

202237_at

KIAA1199

KIAA1199

-3.183

212942_s_at

KRT6A

keratin 6A

-3.215

209125_at

HSD17B2

hydroxysteroid (17-beta) dehydrogenase 2

-3.450

204818_at

KRT14

keratin 14

-3.460

209351_at

SERPINB3 /// SERPINB4

serpin peptidase inhibitor, clade B (ovalbumin), member 3 /// serpin peptidase inhibitor, clade B (ovalbumin), member 4

-8.311

210413_x_at

SERPINB3

serpin peptidase inhibitor, clade B (ovalbumin), member 3

-9.406

209719_x_at

SERPINB3

serpin peptidase inhibitor, clade B (ovalbumin), member 3

-12.240

209720_s_at

SERPINB4

serpin peptidase inhibitor, clade B (ovalbumin), member 4

-17.045

211906_s_at

  1. *Values are mean fold expression changes of three BPH-1 cultures abstracted from Affymetrix datasets. All genes showed significant differential expression (p < 0.05). Positive values indicate upregulation, negative values indicate down regulated genes in the epithelial cells. Hypothetical or unassigned genes were removed from the list.