Effect of Cu supplementation on genomic instability in chemically-induced mammary carcinogenesis in the rat

Table 1 Tumor induction in 7,12-dimethylbenz[a]anthracene treated groups in relation to diet.

Diet	Tumor incidence (%)¹	Number of tumors in one rat	Maximum tumor weight in one rat in group (g)	First week at onset	Body weight ± SD
1. Standard diet	9/9 (100)	1-5	12	15	206 ± 8*
2. Copper 1.3 mg/ml (42.6 mg Cu/kg diet)	9/9 (100)	1-5	7	14	231 ± 22
3. Copper 1.3 mg/ml (42.6 mg Cu/kg diet) and resveratrol 0.1 mg/ml (0.2 mg/kg bw)	12/12 (100)	2-6	11	14	229 ± 13*

The data refer to tumors evaluated at 20 weeks of the animals' age (decapitation time).
¹ Tumor incidence is expressed as the number of tumor-bearing rats over the total number of rats in the group.
* - statistical significance p < 0.05

ISSN: 1423-0127