Table 1 Characteristics of patients with first-ever ischemic stroke and healthy control subjects
Characteristic | Cases (n = 765) | Controls (n = 977) | P-value |
|---|---|---|---|
Age, mean (SD), y | 62.8 ± 12.2 | 63.4 ± 11.9 | 0.526 |
Male, % | 66.1 | 67.9 | 0.480 |
Hypertension, % | 71.1 | 53.9 | < 0.0001 |
Diabetes mellitus, % | 43.2 | 16.1 | < 0.0001 |
Heart disease, % | 25.8 | 15.8 | < 0.0001 |
Ever smoking, % | 51.4 | 31.8 | < 0.0001 |
Ever drinking, % | 25.0 | 15.3 | < 0.0001 |
Body mass index, mean (SD), kg/m2 | 25.3 ± 3.9 | 24.7 ± 3.3 | 0.001 |
Fasting glucose, means (SD), mmol/L | 6.9 ± 2.7 | 5.8 ± 1.7 | < 0.0001 |
HDL-C, mean (SD), mmol/L | 1.1 ± 0.4 | 1.3 ± 0.3 | < 0.0001 |
LDL-C, mean (SD), mmol/L | 3.3 ± 1.0 | 3.2 ± 0.8 | 0.024 |
Triglyceride, mean (SD), mmol/L | 1.6 ± 1.1 | 1.5 ± 1.1 | 0.097 |
Cholesterol, mean (SD), mmol/L | 5.0 ± 1.2 | 5.2 ± 0.9 | 0.005 |
NIHSS at baseline, median (IQR) | 3(1-5) | Â | Â |
TOAST, % | Â | Â | Â |
   Large artery atherosclerosis | 26.8 |  |  |
   Small vessel occlusion | 44.7 |  |  |
   Cardioembolism | 7.1 |  |  |
   Specific pathogenesis | 2.6 |  |  |
   Undetermined pathogenesis | 14.0 |  |  |
   Missing | 4.8 |  |  |
rs12425791, n(%) | Â | Â | Â |
   GG | 447(58.4) | 557(57.4) | 0.091 |
   GA | 268(35.0) | 371(38.2) |  |
   AA | 50(6.5) | 43(4.4) |  |
rs11833579, n(%) | Â | Â | Â |
   GG | 338(44.3) | 433(44.9) | 0.431 |
   GA | 325(42.6) | 425(44.0) |  |
   AA | 100(13.1) | 107(11.1) |  |