Table 1 Classification of the hypoxia-regulated genes

Transcription factors

Twist1, Snail, Slug, ZEB1, ZEB2, E12/E47, ID2,EWS-FLI1, β-catenin, CDX2, SMAD7

[13–16, 20–24]

Histone modifiers

JMJD2B, JMJD2C, MLL1

[25–28]

Enzymes

MMP1, MMP3, MT1-MMP, LOX, ADAMTS1, ACE, ACE2, Hsulf-1, IDH2, XPA

[29–33, 35–39]

Receptors, receptor-associated kinase

CXCR4, CX3CR1, Notch, uPAR, PAI-1, 67-kDa laminin receptor, TLR4, c-Met, RON tyrosine kinase

[40–51]

small GTPases, intracellular signaling molecules

Cdc42, Rac1, RhoE, IRS-2

[52–54]

Transporters

glut-1, MDR1, VDAC1

[55–57]

Membrane proteins

ANGPTL4, L1CAM, α5 integrin, CD151, CD24, CD147, Galectin-1, MUC1, Semaphorin 4D, Caveolin-1

[58–66]

Scaffold protein, cytoplasmic protein

HEF1, Liprin-α4

[67, 68]

Matricellular proteins

CYR61, NOV

[69]

microRNAs

miR-210, miR-15b/16, miR-21, miR-372/373, miR-34a, miR-17/20a, miR-103/107, miR-126

[73–80]