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Table 1 Classification of the hypoxia-regulated genes

From: Hypoxia-regulated target genes implicated in tumor metastasis

Biological function Gene symbol/ alias References
Transcription factors Twist1, Snail, Slug, ZEB1, ZEB2, E12/E47, ID2,EWS-FLI1, β-catenin, CDX2, SMAD7 [1316, 2024]
Histone modifiers JMJD2B, JMJD2C, MLL1 [2528]
Enzymes MMP1, MMP3, MT1-MMP, LOX, ADAMTS1, ACE, ACE2, Hsulf-1, IDH2, XPA [2933, 3539]
Receptors, receptor-associated kinase CXCR4, CX3CR1, Notch, uPAR, PAI-1, 67-kDa laminin receptor, TLR4, c-Met, RON tyrosine kinase [4051]
small GTPases, intracellular signaling molecules Cdc42, Rac1, RhoE, IRS-2 [5254]
Transporters glut-1, MDR1, VDAC1 [5557]
Membrane proteins ANGPTL4, L1CAM, α5 integrin, CD151, CD24, CD147, Galectin-1, MUC1, Semaphorin 4D, Caveolin-1 [5866]
Scaffold protein, cytoplasmic protein HEF1, Liprin-α4 [67, 68]
Matricellular proteins CYR61, NOV [69]
microRNAs miR-210, miR-15b/16, miR-21, miR-372/373, miR-34a, miR-17/20a, miR-103/107, miR-126 [7380]