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Figure 7 | Journal of Biomedical Science

Figure 7

From: The anti-malarial drug Mefloquine disrupts central autonomic and respiratory control in the working heart brainstem preparation of the rat

Figure 7

Baroreflex sensitivity and sympathoinhibition upon baroreceptor stimulation in MF is not significantly different from control. Stimulating the baroreceptors, with a transient increase in perfusion pressure (arrows), resulted in a reflex bradycardia (A). Upon application of MF to the perfusate, there was no significant change in baroreflex sensitivity (A and B) or the extent of sympathoinhibition from control (C). Upon baroreceptor stimulation the PND rate increase is significantly attenuated in comparison to control (D) due to the significantly attenuated reduction in Ti duration. (E) Analysis of the respiratory related sympathetic bursts in MF reveals no significant difference in the degree of sympathoinhibition in ∫SND upon baroreceptor stimulation during both the inspiratory and expiratory phase of the PND cycle in comparison to control. Asterisks denote significance, NS; not significant.

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