Figure 3

(A) An electron micrograph from a glomerular area of the chronic group that shows an angiogenic cell island (circle) in enlarged mesangial matrix (MM) during early stage of angiogenesis. Lumen and basal lamina are not seen yet at the cell island. X2000. (B) Immature capillary (hearth-shaped) with a primitive lumen (star) and a macrophage (MA) in an increased mesangial matrix (MM) adherent to existing capillaries (CL), PAG: protein absorption granules in podocyte (PO), PL: Parietal layer. x2470. (C) A glomeruli area of the acute group that shows an immature capillary (circle) in primitive lumen formation stage. A primitive lumen formation (arrow) is observed in the cell island. The enlarged granular endoplasmic reticulum (GER) cisterns and well developed Golgi apparatus (GA) are seen in the endothelial cell's cytoplasm (shown with high magnification in the inset at the upper left x25000). Around immature capillary, a basal lamina can not be seen yet. N: Nucleus. X5000. (D) An area from a glomerulus of the chronic group that shows an immature capillary (circle) in subsequent stage of primitive lumen (stars) formation.x7500 In their cytoplasm, developed granular endoplasmic reticulum cisterns (GER) are seen in the inset at the upper left. X25000. (E) An area from a glomerulus of the acute group that shows an immature capillary (circle) containing an advanced stage of the lumen (stars) with an apoptotic endothelial cell and cell debris. In the periphery of the immature capillary, the basement membrane (arrows) becomes clear. PO: Podocyte, E: Apoptotic Endothelial cell nucleus, PAG: Protein Absorption Granule × 7500. (F) An area from a glomerulus of the chronic group that shows two small immature capillaries at the lumen formation stage (circle) and a foam-cell like macrophage (Ma) nearby. X5400.