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Table 1 Scatchard analysis of [3H]GABA binding against GABA in the cerebral cortex of control and experimental rats

From: Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A

Group

Bmax (fmoles/mg ptn)

Kd (nM)

C

112.3 ± 6.3

2.6 ± 0.3

E

44.0 ± 3.5***

1.5 ± 0.1**

E+B

89.8 ± 5.6@@

2.3 ± 0.2

E+D

93.2 ± 4.7@@

2.2 ± 02

E+C

80.7 ± 5.2@@

2.1 ± 0.1

  1. Values are mean ± SEM of 4-6 separate experiments. Each group consist of 6-8 rats ** p < 0.01, *** p < 0.001 when compared to control, @@ < 0.01, @@@ < 0.001 when compared to epileptic group. C- Control, E- Epileptic, E+B- Epileptic rats treated with Bacopa monnieri, E+D- Epileptic rats treated with Bacoside A and E+C- Epileptic rats treated with Carbamazepine.
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Journal of Biomedical Science

ISSN: 1423-0127