The relationship between osteoclastogenic and anti-osteoclastogenic pro-inflammatory cytokines differs in human osteoporotic and osteoarthritic bone tissues

Table 2 Data on mRNA levels of osteoclast specific genes and RANK/RANKL/OPG genes in OP and OA

Gene symbol	Gene name	OP (n = 23)	OA (n = 31)	OP/OA^a	p value^b
Osteoclast specific genes
*OSCAR*	Osteoclast associated immunoglobulin-like receptor	0.574(0.345;0.854)	1.002(0.732;1.339)	0.54	0.002*
*ITGB3*	β₃ integrin	0.241(0.074;0.586)	0.285(0.143;0.994)	0.85	0.231
*CTSK*	Cathepsin K	0.288(0.121;1.109)	0.263(0.136;0.555)	1.10	0.786
*ACP5*	Tartrate resistant acid phosphatase (TRAP)	0.270(.128;1.011)	0.147(0.073;0.259)	1.84	0.049*
*CALCR*	Calcitonin receptor	0.223(0.138;0.644)	0.860(0.482;1.562)	0.26	< 0.0005**
RANK/RANKL/OPG genes
*TNFRSF11A*	Receptor activator of nuclear factor κB (RANK)	1.580(0.687;3.939)	0.573(0.355;1.038)	2.76	0.002*
*TNFSF11*	Receptor activator of nuclear factor κB ligand (RANKL)	0.528(0.076;1.038)	0.091(0.027;0.253)	5.80	< 0.0005**
*TNFRSF11B*	Osteoprotegerin (OPG)	0.699(0.410;0.914)	0.776(0.308;1.615)	0.90	0.681
*TNFSF11/TNFRSF11A*	RANKL/RANK	0.241(0.083;0.928)	0.140(0.064;0.271)	1.72	0.076
*TNFSF11/TNFRSF11B*	RANKL/OPG	0.448(0.295;1.601)	0.112(0.075;0.193)	4.00	< 0.0005**

Values are medians(25th;75th percentile). All mRNA values were normalized to the geometric mean of GAPDH and RPLP0 mRNA.
^aGene expression ratio of medians in osteoporotic (OP) versus osteoarthritic (OA) patients.
^bComparisons were assessed by the Mann-Whitney U test. *p < 0.05, **p < 0.001.

ISSN: 1423-0127