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Table 2 Data on mRNA levels of osteoclast specific genes and RANK/RANKL/OPG genes in OP and OA

From: The relationship between osteoclastogenic and anti-osteoclastogenic pro-inflammatory cytokines differs in human osteoporotic and osteoarthritic bone tissues

Gene symbol Gene name OP (n = 23) OA (n = 31) OP/OAa p valueb
Osteoclast specific genes
OSCAR Osteoclast associated immunoglobulin-like receptor 0.574(0.345;0.854) 1.002(0.732;1.339) 0.54 0.002*
ITGB3 β3 integrin 0.241(0.074;0.586) 0.285(0.143;0.994) 0.85 0.231
CTSK Cathepsin K 0.288(0.121;1.109) 0.263(0.136;0.555) 1.10 0.786
ACP5 Tartrate resistant acid phosphatase (TRAP) 0.270(.128;1.011) 0.147(0.073;0.259) 1.84 0.049*
CALCR Calcitonin receptor 0.223(0.138;0.644) 0.860(0.482;1.562) 0.26 < 0.0005**
RANK/RANKL/OPG genes
TNFRSF11A Receptor activator of nuclear factor κB (RANK) 1.580(0.687;3.939) 0.573(0.355;1.038) 2.76 0.002*
TNFSF11 Receptor activator of nuclear factor κB ligand (RANKL) 0.528(0.076;1.038) 0.091(0.027;0.253) 5.80 < 0.0005**
TNFRSF11B Osteoprotegerin (OPG) 0.699(0.410;0.914) 0.776(0.308;1.615) 0.90 0.681
TNFSF11/TNFRSF11A RANKL/RANK 0.241(0.083;0.928) 0.140(0.064;0.271) 1.72 0.076
TNFSF11/TNFRSF11B RANKL/OPG 0.448(0.295;1.601) 0.112(0.075;0.193) 4.00 < 0.0005**
  1. Values are medians(25th;75th percentile). All mRNA values were normalized to the geometric mean of GAPDH and RPLP0 mRNA.
  2. aGene expression ratio of medians in osteoporotic (OP) versus osteoarthritic (OA) patients.
  3. bComparisons were assessed by the Mann-Whitney U test. *p < 0.05, **p < 0.001.