Figure 3
From: The role of thrombomodulin lectin-like domain in inflammation
TMD1 interferes with LPS-mediated inflammation. Soluble TMD1 binds to Lewis Y antigen on the LPS, thereby preventing engagement of LPS, CD14, and TLR4, resulting in reduced activity of NFκB and mitogen activated kinase/ERK pathways. LeY, Lewis Y antigen; TLR4, toll-like receptor 4; NFκB, nuclear factor κB; ERK, extracellular signal regulated protein kinases.