Figure 7
Ubiquitination in RVLM precipitates fatality during experimental brain death. Survival rate of rats that received pretreatment by microinjection bilaterally into RVLM of lactacystin (Lacta; 1 nmol) (upper diagram), proteasome inhibitor II (PiII; 1 nmol) (lower diagram) or their solvents (Vehicle), followed by intravenous administration (at arrows) of LPS (15 mg kg-1) or saline. Values are mean ± SEM, n = 7–8 animals at the beginning of the experiment. Significant difference versus Vehicle + LPS group in the Fisher exact test.