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Figure 5 | Journal of Biomedical Science

Figure 5

From: Autophagy-related gene 7 is downstream of heat shock protein 27 in the regulation of eye morphology, polyglutamine toxicity, and lifespan in Drosophila

Figure 5

Atg7 Is Downstream of Hsp27 in the Regulation of Drosophila Lifespan. (A, B, E, F) RT-PCR verifies that the transcript levels of Hsp27 and Atg7 are altered upon Gal4 induction. (C, D) RNAi knockdown of Hsp27 by hs-Gal4 and da-Gal4 both reduce Drosophila lifespan. (G) Overexpression of Atg7 by hs-Gal4 increases Drosophila lifespan. (H) Knockdown of Atg7 by hs-Gal4 decreases Drosophila lifespan. (I) Neuronal overexpression of Atg7 by appl-Gal4 enhances Drosophila lifespan. (J) Overexpression of Atg7 along with knockdown of Hsp27 by appl-Gal4 displays extended lifespan. On the other hand, simultaneous knockdown of Atg7 and overexpression of Hsp27 exhibits reduced lifespan.

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Journal of Biomedical Science

ISSN: 1423-0127