Figure 9

Comparison docking results of SC44463 in Human MMP7 and in 3.4.24.11 protease and other protease drugs. (A) The structure of the SC44463, BB94 amd Phosphoramidon is presented as colored stick model. (B) The SC44463 was docked onto human MMP7. Illustration of three histidine (His120, His124, His138) of human MMP7 in SC44463-Huaman MMP-7 complex. SC44463 is presented as rice white stick model and HLH of human MMP7 is shown as yellow ribbon. CCT-Thermolysin complex (PDB code: 1THL). The N-(<1-[(2 S)-2-carboxy-4-phenylbutyl]cyclopentyl > carbonyl)-L-tryptophan (CCT) as 3.4.24.11 protease inhibitor is presented as rice white stick model and SC44463 is presented as sky blue stick model. It should be notice that SC44463 could not dock in to 3.4.24.11 protease very well. The huamn MMP7 is presented with ribbon model, HLH shown in yellow, TAD shown in red. The docking result of SC44463-Huaman MMP-7 complex and BB94 shows that the pi-pi and hydrophobic interaction of SC44463 is better than BB94. The SC44463 is presented as sky blue stick model and BB94 is presented as rice white stick model.