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Figure 6 | Journal of Biomedical Science

Figure 6

From: Insulin receptor substrate-1 prevents autophagy-dependent cell death caused by oxidative stress in mouse NIH/3T3 cells

Figure 6

IRS-1 reduces the oxidative stress-mediated autophagy. Control cells and cells overexpressing IRS-1 were treated with vehicle (DMSO) or 10 mU/ml GO for 6 h. Changes in the extent of phosphorylation of p70 S6K at Thr 389 and in LC3B-II levels were analyzed by Western blotting (left). The levels of phosphorylated p70 S6K and LC3B-II were normalized to that of actin for comparison (right).

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Journal of Biomedical Science

ISSN: 1423-0127