Levels and values of circulating endothelial progenitor cells, soluble angiogenic factors, and mononuclear cell apoptosis in liver cirrhosis patients

Table 3 Flow Cytometric Analysis and Laboratory Findings of 78 Study Patients

Variables	Child’s class A (n = 9)	Child’s class B (n = 26)	Child’s class C (n = 43)	p value*
EPC surface makers (double stains)
CD31/CD34 (%)	1.23 ± 0.44	0.90 ± 0.52	1.03 ± 0.61	0.279
KDR/CD34 (%)	1.60 ± 0.51^a	0.97 ± 0.63^b	1.03 ± 0.61^b	0.013
CXCR4/CD34 (%)	1.49 ± 0.56^a	1.20 ± 0.63^b	1.00 ± 0.61^b	0.043
Early apoptosis (%)	13.5 ± 8.9	16.8 ± 10.8	19.7 ± 12.5	0.281
Late apoptosis (%)	1.66 ± 1.62^a	3.12 ± 4.50^b	3.67 ± 3.7^b	0.046
Hemoglobin (g/dl)	12.2 ± 2.2	10.1 ± 2.5	11.1 ± 2.2	0.110
WBC count (x 10³/dl)	5.0 ± 2.1	8.7 ± 12.5	8.8 ± 12.3	0.700
Platelet count (x 10⁴/dl)	13.6 ± 11.9	11.0 ± 5.5	10.3 ± 5.7	0.930
Creatinine (mg/dl)	0.84 ± 0.23	0.93 ± 0.34	1.08 ± 0.74	0.805
Albumin (g/dl)	2.54 ± 0.33^a	2.89 ± 0.54^b	2.87 ± 0.58^b	0.005
AST (U/L)	50.0 ± 23.6	114.0 ± 152.1	98.0 ± 80.4	0.097
ALT (U/ml)	45.0 ± 32.5	83.6 ± 195.2	63.5 ± 67.7	0.361
Prothrombin time (sec)	11.0 ± 0.7^a	13.6 ± 3.9^b	13.2 ± 2.2^b	0.006
α-fetoprotein (ng/ml)	8.3 ± 3.2	75.8 ± 223.5	1187.5 ± 6495.3	0.430
Total bilirubin (mg/dl)	0.8 ± 0.2^a	3.4 ± 3.2^b	4.8 ± 6.4^b	0.0002
VEGF (pg/ml)	25.0 ± 11.4^a	54.1 ± 22.4^b	62.6 ± 59.8^b	0.039
SDF-1α (pg/ml)	2030.1 ± 446.4	2246.1 ± 808.0	2309.8 ± 687.6	0.350

Data expressed as mean ± SD or % (No).
ALT = Alanine aminotransferase; AST = aspartate aminotransferase; SDF = stromal cell-derived factor; VEGF = vascular endothelial cell growth factor; WBC = white blood cell.
* Continuous data were analyzed using Kruskal-Wallis test. Letters (^{a, b}) indicate significant difference (at 0.05 level) (by Wilcoxon rank sum test with Bonferroni’s correction).

ISSN: 1423-0127