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Table 2 HLA-DQ status and risk of Celiac disease

From: HLA-DQA1 and HLA-DQB1 in Celiac disease predisposition: practical implications of the HLA molecular typing

HLA status

Disease risk

DQ2.5 and DQ8

Very high

DQ2.5 (with a double dose of DQB1*02)

Very high

DQ8

High

DQ2.5 (with a single dose of DQB1*02)

High

DQ2.x (with a double dose of DQB1*02)

High

DQ2.x (with a single dose of DQB1*02)

Low

DQX.5

Extremely low

DQX.x

Extremely low

  1. x = DQA1 alleles different from *05.
  2. X = DQB1 alleles different from *02 and *03:02.
  3. Disease risks for each HLA genotype are based on published data by Megiorni et al.[49].
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Journal of Biomedical Science

ISSN: 1423-0127