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Table 2 HLA-DQ status and risk of Celiac disease

From: HLA-DQA1 and HLA-DQB1 in Celiac disease predisposition: practical implications of the HLA molecular typing

HLA status Disease risk
DQ2.5 and DQ8 Very high
DQ2.5 (with a double dose of DQB1*02) Very high
DQ8 High
DQ2.5 (with a single dose of DQB1*02) High
DQ2.x (with a double dose of DQB1*02) High
DQ2.x (with a single dose of DQB1*02) Low
DQX.5 Extremely low
DQX.x Extremely low
  1. x = DQA1 alleles different from *05.
  2. X = DQB1 alleles different from *02 and *03:02.
  3. Disease risks for each HLA genotype are based on published data by Megiorni et al.[49].