Figure 4

Activation of JNK in RVLM sustained central cardiovascular regulation associated with experimental brain stem death. Temporal changes in mean systemic arterial pressure (MSAP), hear rate (HR) or power density of the low-frequency (LF) component of SAP signals in rats that received pretreatment by microinjection bilaterally into RVLM of aCSF (vehicle), JNK inhibitor I (JNK inhibitor), SP600125(JNK inhibitor) or JNK inhibitor I negative control (negative control for JNK inhibitors), 30 min before local application (at arrow) of aCSF or Mev(10 nmol) to the bilateral RVLM. Values are mean ± SEM, n = 5-7 animals per experimental group. *P < 0.05 versus aCSF+aCSF group, and ⁺P < 0.05 versus aCSF+Mev group at corresponding time-points in the post hoc Scheffé multiple-range test.