Figure 1

Co-administration of dectin-1 agonists suppresses the epicutaneously OVA-induced Th2 immune response. (A) Groups of BALB/c mice (n=5) were sensitized by patch application with OVA plus doses of curdlan or OVA alone on day1-5. (B) Groups of BALB/c mice (n=5) were sensitized by patch application with OVA plus zymosan, OVA plus Pam3CSK4 and doses of curdlan, or OVA alone on day 1–5. Ten days after the start of the sensitization course, draining LNs were obtained. The IL-5 and IL-13 contents in supernatants of in vitro OVA reactivation culture of LN cells were determined by ELISA. Net concentrations (concentration in the absence of OVA subtracted from concentration in the presence of OVA) were presented. Data are representative of at least three independent experiments.