Figure 6

Cytotoxicity of honokiol and comparison to honokiol inhibition of SOCE. The cytotoxicity of honokiol following a 24 h exposure period is presented as fractional decrease in cells capable of maintaining an intracellular reducing environment (open circles). Fractional inhibition of SOCE by a 10 min exposure to honokiol was determined in two ways: 1) depression of sustained calcium entry (●) (e.g., Figure 1) and 2) inhibition of calcium influx following thapsigargin depletion of ER calcium stores (▲) (e.g., Figure 3).