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Table 6 Prediction performance of in silico tools in the whole data set

From: CoDP: predicting the impact of unclassified genetic variants in MSH6 by the combination of different properties of the protein

 

CoDP

MAPP for MSH6

SIFT

PolyPhen2 HumVar

PolyPhen2 HumDiv

TP

14

14

10

14

14

TN

18

17

15

10

8

FP

1

1

4

9

11

FN

1

2

5

1

1

PP0V

0.933 (14/15)

0.875 (14/16)

0.714 (10/14)

0.609 (14/23)

0.560 (14/25)

NPV

0.947 (18/19)

0.944 (17/18)

0.750 (15/20)

0.909 (10/11)

0.889 (8/9)

Sencitivity

0.933 (14/15)

0.875 (14/15)

0.667 (10/15)

0.933 (14/15)

0.933 (14/15)

Specificity

0.941 (32/34)

0.912 (31/34)

0.735 (25/34)

0.706 (24/34)

0.647 (22/34)