Figure 6
MFN2 overexpression lowered lipid intermediate accumulation in rat skeletal muscle, but had no significant effect on muscle TG accumulation. Rats were fed with high-fat diets for 8 weeks, and then were infected with Ad-Mfn2 (109 v.p./kg body weight) or empty Ad adenoviruses or PBS control for 3 weeks. The levels of TG (A), LCCoAs (B), DAG (C) and CER (D) were measured. *P < 0.05, **P <0.01, compared with Ad, n = 6.