Figure 2

A20 and p53 levels in colon polyps and rate of polyp relapse. A, the bars indicate the levels of A20 and p53 in colon polyp tissue (assessed by ELISA). Polyp-1: Polyp samples were collected from 136 patients with colon polyposis. Polyp-2: Polyp samples were collected from 59 patients with relapsed polyposis. *, p < 0.05, compared with control (samples were obtained from IBS patients; see Figure 1). B, the bars indicate the number of patients whose polyposis relapsed. The X axis indicate the time intervals when the polyposis relapsed. C-D, the dot plots present the correlation between polyp history and A20 (C) or p53 (D) levels in polyp tissue with the raw data. E, the bars indicate the levels of A20 of p53 in colon polyps of different pathological phenotypes. F, the bars indicate the A20 levels in colon polyps of different pathological types of polyps. The X axis of E and F indicate the pathological types of colon polyps (the “1” indicates before the diagnosis of cancer; the “2” indicates after the diagnosis of cancer). The data in bar graphs were presented as mean ± SD. *, p < 0.05, compared with control group (IBS group; see Figure 1 in detail). #, p < 0.01, compared with adenomas group. Samples from individual patients were processed separately. Each experiment was repeated 3 times. Cancerous: The colon polyp developed into cancer.