Figure 10

Protein expressions of fibrotic and anti-fibrotic markers in infarct area (IA) and peri-IA by day 21 after AMI. A) The protein expression of transforming growth factor (TGF)-β in IA. * vs. other bars with different symbols, p<0.001. B) The protein expression of TGF-β in peri-IA. * vs. other bars with different symbols, p<0.001. C) The protein expression of phosphorylated (p)-Smad3 in IA. * vs. other bars with different symbols, p<0.01. D) The protein expression of p-Smad3 in peri-IA. * vs. other bars with different symbols, p<0.01. E) The protein expression of bone morphogenic protein (BMP)-2 in IA. * vs. other bars with different symbols, p<0.001. F) The protein expression of BMP-2 in peri-IA. * vs. other bars with different symbols, p<0.01. G) The protein expression of p-Smad1/5 in IA. * vs. other bars with different symbols, p<0.001. H) The protein expression of p-Smad1/5 in peri-IA. * vs. other bars with different symbols, p<0.001. All statistical analyses using one-way ANOVA, followed by Bonferroni multiple comparison post hoc test. Symbols (*, †, ‡) indicate significance (at 0.05 level). NC = normal control; AMI = acute myocardial infarction; Tac = tacrolimus. (n=6 for each group).