Figure 1
Effect of leptin on the left atrial (LA) electrical activity and effects of isoproterenol on control and leptin-treated left atrial (LA) myocytes. A. Examples and average data of the action potential from control (n = 22) LA myocytes and leptin-treated LA myocytes (n = 19). Leptin-treated LA myocytes had longer APD20. B. Examples of isoproterenol-induced DAD (★) from control and leptin-treated LA myocytes. The incidence of isoproterenol-induced DADs from control (n = 24) and leptin-treated (n = 21) LA myocytes. RMP resting membrane potential, APA action potential amplitude, APD90 90% action potential duration, APD50 50% action potential duration, APD20 20% action potential duration. *p < 0.05 versus control LA myocytes.