Copy number variation analysis in non-smoking female lung adenocarcinoma patients. (A) Distribution of genome-wide CNV using Affymetrix GeneChip® SNP 6.0 analysis. The criteria for the CNV regions were that SNPs must have copy numbers >2.5 or <1.5 and there must be at least 100 continuous SNP variant loci. Grey bars indicate regions with gains (above) or losses (below) in copy number. Black bars indicate that ≥30% of the patients had a particular CNV. (B) Common gain regions (≥30% of patients) of CNVs (grey area) were identified in 7p21.3-7p21.1 and 7p11.2. Black lines of each row indicate regions with copy number amplifications at >100 continuous SNP loci for each patient. (C) TaqMan assay validation of CNVs in chromosome 7p21.1. Four CNV regions (black block 1–4) identified by SNP arrays were examined using TaqMan® copy number assays (grey block).