Figure 2

The tumor and serum (the representative HT29 tumor bearing mouse) was pretreated with excess fold of bevacizumab: tumor VEGF (a-b) and serum VEGF (c-d). Tumor VEGF in the pretreated group of mice is significantly (p = 0.002) suppressed (b) in the accumulation of bevacizumab-AlexaFluor 750 in comparing with untreated tumor Figure 2(a), while the serum VEGF is relatively higher (d) comparing to the untreated serum (c).