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Table 5 Experimental ED 50 values, without and with naltrexone (NTX) 1 mg/kg i.p., naltrindole (NTI) 2 mg/kg i.p. and nor-BNI 3 mg/kg i.p. for the antinociceptive activity of the intraperitoneal coadministration of morphine with methadone, morphine with fentanyl, and morphine with tramadol, fentanyl with methadone, methadone with tramadol, and fentanyl with tramadol in the writhing test of mice

From: Isobolographic analysis of the opioid-opioid interactions in a tonic and a phasic mouse model of induced nociceptive pain

Drugs

Experimental ED50

 

Alone

+NTX

+NTI

+ nor-BNI

 

(n = 24)

(n = 24)

(n = 24)

(n = 24)

Methadone/fentanyl

0.019

0.048*

0.21*

0.018

Morphine/Methadone

0.023

0.095*

0.089*

0.019

Morphine/fentanyl

0.034

0.061*

0.058*

0.027

Morphine/tramadol

0.811

1.05*

1.10*

0.752

Fentanyl/tramadol

1.023

1.27*

1.31*

1.010

Methadone/tramadol

1.032

1.25*

1.32*

1.024

  1. *P < 0.05 compared with ED50 experimental alone.
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Journal of Biomedical Science

ISSN: 1423-0127