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Table 3 Dual energy X-ray absorption (DXA) analysis of bone- and weight-related parameters in line Slc12a1 I299F at the age of 21 weeks

From: Standardized, systemic phenotypic analysis of Slc12a1I299F mutant mice

 

Males

Females

Parameter

Homozygous mutants

Heterozygous mutants

Homozygous mutants

Heterozygous mutants

Body length (cm)

10.3 ± 0.1

10.3 ± 0.1

10.3 ± 0.1

10.4 ± 0.1

Body weight (g)

33.3 ± 0.5c

40.0 ± 1.0

32.1 ± 1.1a

35.9 ± 1.4

Lean mass (units)

23.0 ± 1.0b

17.1 ± 1.3

18.7 ± 1.0b

14.1 ± 0.9

Lean content (units × 100/g)

69.0 ± 2.7c

42.7 ± 3.2

59.4 ± 4.4b

40.1 ± 3.7

Fat mass (units)

6.7 ± 0.9c

18.6 ± 1.4

9.7 ± 1.8b

17.7 ± 1.9

Fat content (units × 100/g)

20.2 ± 2.6c

46.4 ± 3.1

29.0 ± 4.4b

48.2 ± 3.6

BMD (mg/cm2)

67 ± 1c

75 ± 1

70 ± 1b

75 ± 1

sBMD (10−3 × cm−2)

2.0 ± 0.1

1.9 ± 0.1

2.2 ± 0.04

2.1 ± 0.1

BMC (mg)

890 ± 45c

1306 ± 67

966 ± 68a

1234 ± 67

Bone content (%)

2.7 ± 0.1a

3.3 ± 0.2

3.0 ± 0.1b

3.4 ± 0.1

  1. BMC, bone mineral content; BMD, bone mineral density; sBMD, specific bone mineral density.
  2. No. per genotype and sex: n = 9–11. Data are presented as mean ± standard error of mean. Student’s t-test vs. heterozygous mutants as controls: aP < 0.05, bP < 0.01, cP < 0.001.