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Table 3 Dual energy X-ray absorption (DXA) analysis of bone- and weight-related parameters in line Slc12a1 I299F at the age of 21 weeks

From: Standardized, systemic phenotypic analysis of Slc12a1I299F mutant mice

  Males Females
Parameter Homozygous mutants Heterozygous mutants Homozygous mutants Heterozygous mutants
Body length (cm) 10.3 ± 0.1 10.3 ± 0.1 10.3 ± 0.1 10.4 ± 0.1
Body weight (g) 33.3 ± 0.5c 40.0 ± 1.0 32.1 ± 1.1a 35.9 ± 1.4
Lean mass (units) 23.0 ± 1.0b 17.1 ± 1.3 18.7 ± 1.0b 14.1 ± 0.9
Lean content (units × 100/g) 69.0 ± 2.7c 42.7 ± 3.2 59.4 ± 4.4b 40.1 ± 3.7
Fat mass (units) 6.7 ± 0.9c 18.6 ± 1.4 9.7 ± 1.8b 17.7 ± 1.9
Fat content (units × 100/g) 20.2 ± 2.6c 46.4 ± 3.1 29.0 ± 4.4b 48.2 ± 3.6
BMD (mg/cm2) 67 ± 1c 75 ± 1 70 ± 1b 75 ± 1
sBMD (10−3 × cm−2) 2.0 ± 0.1 1.9 ± 0.1 2.2 ± 0.04 2.1 ± 0.1
BMC (mg) 890 ± 45c 1306 ± 67 966 ± 68a 1234 ± 67
Bone content (%) 2.7 ± 0.1a 3.3 ± 0.2 3.0 ± 0.1b 3.4 ± 0.1
  1. BMC, bone mineral content; BMD, bone mineral density; sBMD, specific bone mineral density.
  2. No. per genotype and sex: n = 9–11. Data are presented as mean ± standard error of mean. Student’s t-test vs. heterozygous mutants as controls: aP < 0.05, bP < 0.01, cP < 0.001.