Table 4 Metastasis-associated biological functions of selected target transcripts of miRNA-5p and -3p sister pairs 1
From: MicroRNA-5p and -3p co-expression and cross-targeting in colon cancer cells
| miRNA family | miRNA | Chrom’l location | Expression | Selected target mRNAs2 | Functions3 |
|---|---|---|---|---|---|
| let-7 | let-7 g-5p | 3p21.1 | Up-reg’d | IGF1R* | Angiogenesis, apoptosis |
| MYC* | Angiogenesis, apoptosis, cancer, Jak-STAT, MAPK & Wnt signaling | ||||
| let-7 g-3p | Up-reg’d | ZEB1 | EMT, transcriptional misregulation in cancer | ||
| NLK | Angiogenesis, MAPK & Wnt signaling | ||||
| let-7d-5p | 9q22.32 | Up-reg’d | IGF1R* | Angiogenesis, apoptosis | |
| THBS1* | Angiogenesis, cell cycle, p53 signaling, cancer | ||||
| let-7d-3p | Down-reg’d | KRAS | Apoptosis, MAPK & VEGF signaling, cancer | ||
| PRKACB | Apoptosis, MAPK, Wnt & Hedgehog signaling | ||||
| let-7i-5p | 12q14.1 | Up-reg’d | TLR4* | Toll-like receptor signaling, inflammatory response | |
| IL13* | Cell-cell signaling, Jak-STAT, Toll-like receptor signaling, cytokine-cytokine receptor interaction | ||||
| let-7i-3p | Up-reg’d | DLX5 | Cell proliferation | ||
| ACTB | Focal adhesion, leukocyte transendothelial migration | ||||
| mir-8/200 | miR-200a-5p | 1p36.33 | Up-reg’d | ZEB2 | EMT, Wnt signaling |
| FGF4 | Apoptosis, MAPK signaling | ||||
| miR-200a-3p | Up-reg’d | ZEB1* | EMT, transcriptional misregulation in cancer | ||
| ZEB2* | EMT, Wnt signaling | ||||
| miR-200b-5p | 1p36.33 | Down-reg’d | ZEB2 | EMT, Wnt signaling | |
| PRDM6 | Chromatin modification | ||||
| miR-200b-3p | Up-reg’d | ZEB1* | EMT, transcriptional misregulation in cancer | ||
| MLH1 | Mismatch repair, cancer | ||||
| miR-141-5p | 12p13.31 | Up-reg’d | ATM | Apoptosis, cell cycle, p53 signaling, cancer | |
| CLDN1 | Cell adhesion, leukocyte transendothelial migration | ||||
| miR-141-3p | Up-reg’d | MYC* | Angiogenesis, apoptosis, cancer, Jak-Stat, MAPK & Wnt signaling | ||
| TP53* | Angiogenesis, apoptosis, cell cycle, MAPK, p53 & Wnt signaling, cancer | ||||
| mir-17 | miR-17-5p | 13q31.3 | Up-reg’d | THBS1* | Angiogenesis, cell cycle, p53 signaling, cancer |
| E2F1* | Apoptosis, cell cycle, cancer | ||||
| miR-17-3p | Up-reg’d | CD44 | Angiogenesis, inflammation, cancer | ||
| MYB | Cancer | ||||
| miR-18a-5p | 13q31.3 | Up-reg’d | THBS1* | Angiogenesis, cell cycle, p53 signaling, cancer | |
| HIF1A* | Angiogenesis, cell migration, VEGF signaling | ||||
| miR-18a-3p | Up-reg’d | KRAS* | Apoptosis, MAPK & VEGF signaling, cancer | ||
| CASP7 | Apoptosis | ||||
| miR-20a-5p | 13q31.3 | Up-reg’d | THBS1* | Angiogenesis, cell cycle, p53 signaling, cancer | |
| E2F1* | Apoptosis, cell cycle, cancer | ||||
| miR-20a-3p | Up-reg’d | KRAS | Apoptosis, MAPK & VEGF signaling, cancer | ||
| PCNA | Cell cycle, cancer |