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Table 4 Metastasis-associated biological functions of selected target transcripts of miRNA-5p and -3p sister pairs 1

From: MicroRNA-5p and -3p co-expression and cross-targeting in colon cancer cells

miRNA family miRNA Chrom’l location Expression Selected target mRNAs2 Functions3
let-7 let-7 g-5p 3p21.1 Up-reg’d IGF1R* Angiogenesis, apoptosis
     MYC* Angiogenesis, apoptosis, cancer, Jak-STAT, MAPK & Wnt signaling
  let-7 g-3p   Up-reg’d ZEB1 EMT, transcriptional misregulation in cancer
     NLK Angiogenesis, MAPK & Wnt signaling
  let-7d-5p 9q22.32 Up-reg’d IGF1R* Angiogenesis, apoptosis
     THBS1* Angiogenesis, cell cycle, p53 signaling, cancer
  let-7d-3p   Down-reg’d KRAS Apoptosis, MAPK & VEGF signaling, cancer
     PRKACB Apoptosis, MAPK, Wnt & Hedgehog signaling
  let-7i-5p 12q14.1 Up-reg’d TLR4* Toll-like receptor signaling, inflammatory response
     IL13* Cell-cell signaling, Jak-STAT, Toll-like receptor signaling, cytokine-cytokine receptor interaction
  let-7i-3p   Up-reg’d DLX5 Cell proliferation
     ACTB Focal adhesion, leukocyte transendothelial migration
mir-8/200 miR-200a-5p 1p36.33 Up-reg’d ZEB2 EMT, Wnt signaling
     FGF4 Apoptosis, MAPK signaling
  miR-200a-3p   Up-reg’d ZEB1* EMT, transcriptional misregulation in cancer
     ZEB2* EMT, Wnt signaling
  miR-200b-5p 1p36.33 Down-reg’d ZEB2 EMT, Wnt signaling
     PRDM6 Chromatin modification
  miR-200b-3p   Up-reg’d ZEB1* EMT, transcriptional misregulation in cancer
     MLH1 Mismatch repair, cancer
  miR-141-5p 12p13.31 Up-reg’d ATM Apoptosis, cell cycle, p53 signaling, cancer
     CLDN1 Cell adhesion, leukocyte transendothelial migration
  miR-141-3p   Up-reg’d MYC* Angiogenesis, apoptosis, cancer, Jak-Stat, MAPK & Wnt signaling
     TP53* Angiogenesis, apoptosis, cell cycle, MAPK, p53 & Wnt signaling, cancer
mir-17 miR-17-5p 13q31.3 Up-reg’d THBS1* Angiogenesis, cell cycle, p53 signaling, cancer
     E2F1* Apoptosis, cell cycle, cancer
  miR-17-3p   Up-reg’d CD44 Angiogenesis, inflammation, cancer
     MYB Cancer
  miR-18a-5p 13q31.3 Up-reg’d THBS1* Angiogenesis, cell cycle, p53 signaling, cancer
     HIF1A* Angiogenesis, cell migration, VEGF signaling
  miR-18a-3p   Up-reg’d KRAS* Apoptosis, MAPK & VEGF signaling, cancer
     CASP7 Apoptosis
  miR-20a-5p 13q31.3 Up-reg’d THBS1* Angiogenesis, cell cycle, p53 signaling, cancer
     E2F1* Apoptosis, cell cycle, cancer
  miR-20a-3p   Up-reg’d KRAS Apoptosis, MAPK & VEGF signaling, cancer
     PCNA Cell cycle, cancer
  1. 1A complete list of predicated/validated target transcripts and putative regulated biological functions is presented in Additional file 5. 2Asterisks in the column indicate validated targets as tabulated in miRBase. 3Data were derived from the Gene Ontology Annotation Database (UniProt-GOA) and the KEGG Pathway databases.