Table 4 Metastasis-associated biological functions of selected target transcripts of miRNA-5p and -3p sister pairs ¹

let-7

let-7 g-5p

3p21.1

Up-reg’d

IGF1R*

Angiogenesis, apoptosis

MYC*

Angiogenesis, apoptosis, cancer, Jak-STAT, MAPK & Wnt signaling

let-7 g-3p

Up-reg’d

ZEB1

EMT, transcriptional misregulation in cancer

NLK

Angiogenesis, MAPK & Wnt signaling

let-7d-5p

9q22.32

Up-reg’d

IGF1R*

Angiogenesis, apoptosis

THBS1*

Angiogenesis, cell cycle, p53 signaling, cancer

let-7d-3p

Down-reg’d

KRAS

Apoptosis, MAPK & VEGF signaling, cancer

PRKACB

Apoptosis, MAPK, Wnt & Hedgehog signaling

let-7i-5p

12q14.1

Up-reg’d

TLR4*

Toll-like receptor signaling, inflammatory response

IL13*

Cell-cell signaling, Jak-STAT, Toll-like receptor signaling, cytokine-cytokine receptor interaction

let-7i-3p

Up-reg’d

DLX5

Cell proliferation

ACTB

Focal adhesion, leukocyte transendothelial migration

mir-8/200

miR-200a-5p

1p36.33

Up-reg’d

ZEB2

EMT, Wnt signaling

FGF4

Apoptosis, MAPK signaling

miR-200a-3p

Up-reg’d

ZEB1*

EMT, transcriptional misregulation in cancer

ZEB2*

EMT, Wnt signaling

miR-200b-5p

1p36.33

Down-reg’d

ZEB2

EMT, Wnt signaling

PRDM6

Chromatin modification

miR-200b-3p

Up-reg’d

ZEB1*

EMT, transcriptional misregulation in cancer

MLH1

Mismatch repair, cancer

miR-141-5p

12p13.31

Up-reg’d

ATM

Apoptosis, cell cycle, p53 signaling, cancer

CLDN1

Cell adhesion, leukocyte transendothelial migration

miR-141-3p

Up-reg’d

MYC*

Angiogenesis, apoptosis, cancer, Jak-Stat, MAPK & Wnt signaling

TP53*

Angiogenesis, apoptosis, cell cycle, MAPK, p53 & Wnt signaling, cancer

mir-17

miR-17-5p

13q31.3

Up-reg’d

THBS1*

Angiogenesis, cell cycle, p53 signaling, cancer

E2F1*

Apoptosis, cell cycle, cancer

miR-17-3p

Up-reg’d

CD44

Angiogenesis, inflammation, cancer

MYB

Cancer

miR-18a-5p

13q31.3

Up-reg’d

THBS1*

Angiogenesis, cell cycle, p53 signaling, cancer

HIF1A*

Angiogenesis, cell migration, VEGF signaling

miR-18a-3p

Up-reg’d

KRAS*

Apoptosis, MAPK & VEGF signaling, cancer

CASP7

Apoptosis

miR-20a-5p

13q31.3

Up-reg’d

THBS1*

Angiogenesis, cell cycle, p53 signaling, cancer

E2F1*

Apoptosis, cell cycle, cancer

miR-20a-3p

Up-reg’d

KRAS

Apoptosis, MAPK & VEGF signaling, cancer

PCNA

Cell cycle, cancer