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Table 5 Expression levels of let-7d-5p and -3p and associated putative target transcripts and proteins in colon cancer cell lines

From: MicroRNA-5p and -3p co-expression and cross-targeting in colon cancer cells

miRNA miRNA expression1 Target transcript Protein expression2
(Mean ± SD) (Relative to normal)
let-7d-5p 2.29 ± 1.01 IGF1R 0.33 ± 0.23** (α)
    0.53 ± 0.37** (β)
let-7d-3p −2.78 ± 0.79** KRAS 3.57 ± 1.99**
  1. The colon cancer cells lines used were HT-29, SK-CO-1 and WiDr. 1Real-time PCR was used to determine miRNA and target mRNA levels; the log2 (fold change) values are shown. 2Western blotting was used to determine protein levels and the values were expressed relative to those of normal tissues. In both real-time PCR and western analysis, data were derived from three independent experiments. **p < 0.01.